NAAT1_DROMO
ID NAAT1_DROMO Reviewed; 645 AA.
AC B4L7U0;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 13-OCT-2009, sequence version 2.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=Sodium-dependent nutrient amino acid transporter 1 {ECO:0000250|UniProtKB:Q9W4C5};
GN Name=NAAT1 {ECO:0000250|UniProtKB:Q9W4C5}; ORFNames=GI11052;
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230;
RN [1] {ECO:0000312|EMBL:EDW05515.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22 {ECO:0000312|EMBL:EDW05515.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC cotransporter that promotes absorption of the D isomers of essential
CC amino acids. Neutral amino acids are the preferred substrates,
CC especially methionine and phenylalanine (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDW05515.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CH933814; EDW05515.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_002011525.2; XM_002011489.2.
DR AlphaFoldDB; B4L7U0; -.
DR SMR; B4L7U0; -.
DR STRING; 7230.FBpp0160269; -.
DR EnsemblMetazoa; FBtr0161777; FBpp0160269; FBgn0133815.
DR GeneID; 6585901; -.
DR KEGG; dmo:Dmoj_GI11052; -.
DR eggNOG; KOG3660; Eukaryota.
DR InParanoid; B4L7U0; -.
DR OrthoDB; 250396at2759; -.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0005887; C:integral component of plasma membrane; IC:UniProtKB.
DR GO; GO:0005283; F:amino acid:sodium symporter activity; ISS:UniProtKB.
DR GO; GO:0042943; F:D-amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IEA:EnsemblMetazoa.
DR GO; GO:0015175; F:neutral amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0042940; P:D-amino acid transport; ISS:UniProtKB.
DR GO; GO:0015804; P:neutral amino acid transport; ISS:UniProtKB.
DR GO; GO:0006814; P:sodium ion transport; ISS:UniProtKB.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616; PTHR11616; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SSF161070; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..645
FT /note="Sodium-dependent nutrient amino acid transporter 1"
FT /id="PRO_0000386584"
FT TOPO_DOM 1..51
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..474
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 480..500
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 522..542
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 559..579
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 191
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 205
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 514
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 645 AA; 71994 MW; 40CC811BAF6B32BD CRC64;
MELKTMPHNG ANGSPQHNNN NNSNNNNNVS SDTKTDNNEK EAQKKDEGRT NWSNGIEFLM
SCISVSVGLG NVWRFPFTAY ENGGGAFLIP YIIVLFLIGK PMYYLEMIIG QFTSQGTVKI
WSICPSFVGV GYGQAFATIC IITYYSSLLA LTLYYLFVSF QSELPWSYCR DEWTNCVNSI
PTEFVETALG NTTSALAQQA NTLSNTTKLQ SSSELYFLNV VIKEKSDISD GIGIPDWKLT
IALFVSWVVI FLVIMRGVKS SGKAAYFLAL FPYVVLFALL GRAVTLEGAV DGIIFFLQPQ
WGELLNPIVW KEAVVQCFFS LAVGCGPIIM FASYNRFDHG IYRDAMIVTT LDTLTSLLGG
ITIFAILGNL AHNLKAENIR DVVRSGTGLA FISYPDAISK FQAVPQLFSV LFFFMLFVLG
IGSIVALQST IVTIICDQFK SWKYWKVALA TSACGFLMGL VYVTPGGQWI LTLVDFYGGT
YVVFILAIFE LSGIVWIYGL QNFCDDIEFM SNKNVSMYWR LCWSFFTPVM MIVIFIYSMA
TIQPIKYSDQ YFPLAGDVAG WLLFAVGAAQ FPLWGWWYIA THRHGSCAES IKASLKPSSK
WGPASPENRQ AWLLFKSDLA AKRANEAKSN KFGFFQQKLR NMCGK
