NAAT1_DROPE
ID NAAT1_DROPE Reviewed; 652 AA.
AC B4GVM9;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=Sodium-dependent nutrient amino acid transporter 1 {ECO:0000250|UniProtKB:Q9W4C5};
GN Name=NAAT1 {ECO:0000250|UniProtKB:Q9W4C5}; ORFNames=GL14641;
OS Drosophila persimilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234;
RN [1] {ECO:0000312|EMBL:EDW26724.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC cotransporter that promotes absorption of the D isomers of essential
CC amino acids. Neutral amino acids are the preferred substrates,
CC especially methionine and phenylalanine (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000305}.
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DR EMBL; CH479193; EDW26724.1; -; Genomic_DNA.
DR RefSeq; XP_002022658.1; XM_002022622.1.
DR AlphaFoldDB; B4GVM9; -.
DR SMR; B4GVM9; -.
DR STRING; 7234.FBpp0178748; -.
DR EnsemblMetazoa; FBtr0180256; FBpp0178748; FBgn0152245.
DR GeneID; 6597510; -.
DR KEGG; dpe:6597510; -.
DR eggNOG; KOG3660; Eukaryota.
DR HOGENOM; CLU_006855_9_5_1; -.
DR OMA; WIYGLQN; -.
DR PhylomeDB; B4GVM9; -.
DR Proteomes; UP000008744; Unassembled WGS sequence.
DR GO; GO:0005887; C:integral component of plasma membrane; IC:UniProtKB.
DR GO; GO:0005283; F:amino acid:sodium symporter activity; ISS:UniProtKB.
DR GO; GO:0042943; F:D-amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IEA:EnsemblMetazoa.
DR GO; GO:0015175; F:neutral amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0042940; P:D-amino acid transport; ISS:UniProtKB.
DR GO; GO:0015804; P:neutral amino acid transport; ISS:UniProtKB.
DR GO; GO:0006814; P:sodium ion transport; ISS:UniProtKB.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616; PTHR11616; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SSF161070; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..652
FT /note="Sodium-dependent nutrient amino acid transporter 1"
FT /id="PRO_0000386585"
FT TOPO_DOM 1..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 412..432
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..478
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 485..505
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 527..547
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TRANSMEM 564..584
FT /note="Helical; Name=13"
FT /evidence="ECO:0000255"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 201
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 204
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 652 AA; 72700 MW; A1A536DFD4ACF5C9 CRC64;
MELKGVHQQN GTSNGTGAVG AEGESAPPTA PATAEAAASL ETTTEKVDAE QQKPERTNWG
NGLEFLMSCI SVSVGLGNVW RFPFTAYENG GGAFLIPYII VLFLIGKPMY YLEMIMGQFT
SQGTVKIWSV VPGFVGVGYG QAFATICIIT YYSSLLALTL YYLFVSFQSV LPWSYCWEEW
MNCVDSRPQE DTDALLLSSS NVTNVTALTD TVKLQSSSEL YFLNVVIKEK MDISDGIGDP
DWKLTLALFV SWVVIFLVIM RGVKSSGKAA YFLALFPYVV LFILLVRAVT LEGARDGIIF
FLEPQWGELL NPTVWKNAVV QCFFSLAVGS GPIIMFASYN RFDHGIYRDA MIVTTLDTLT
SLLGGITIFA ILGNLAHNLQ IENIRDVVRS GTGLAFISYP DAISKFQAVP QLFSVLFFFM
LFVLGIGSIV ALQSTIVTIL CDQFKSWKYW KVALATSICG FLMGLVYVTP GGQWILTLVD
FYGGTYVVFI LAIFELAGIV WIYGMQNFCD DVEFMCNRRV SLYWRVCWSF FTPVMMIVIF
IYSMVTIEPI TYSEQFFPEA GNVAGWLLFG IGAAQFPLWW MWYISQHREG SLGQSFVASL
RPSDKWGPAN PETKRQWVIF KNEKAAQRAT KKQSSKLGAF WQKLGHFCGS NT
