NAAT1_DROPS
ID NAAT1_DROPS Reviewed; 653 AA.
AC Q29GB8;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Sodium-dependent nutrient amino acid transporter 1 {ECO:0000250|UniProtKB:Q9W4C5};
GN Name=NAAT1 {ECO:0000250|UniProtKB:Q9W4C5}; ORFNames=GA16959;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1] {ECO:0000312|EMBL:EAL32192.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC cotransporter that promotes absorption of the D isomers of essential
CC amino acids. Neutral amino acids are the preferred substrates,
CC especially methionine and phenylalanine (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000305}.
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DR EMBL; CH379064; EAL32192.1; -; Genomic_DNA.
DR RefSeq; XP_001355135.1; XM_001355099.2.
DR AlphaFoldDB; Q29GB8; -.
DR SMR; Q29GB8; -.
DR STRING; 7237.FBpp0287735; -.
DR EnsemblMetazoa; FBtr0289297; FBpp0287735; FBgn0076973.
DR GeneID; 4815002; -.
DR KEGG; dpo:Dpse_GA16959; -.
DR eggNOG; KOG3660; Eukaryota.
DR HOGENOM; CLU_006855_9_5_1; -.
DR InParanoid; Q29GB8; -.
DR OMA; WIYGLQN; -.
DR PhylomeDB; Q29GB8; -.
DR Proteomes; UP000001819; Chromosome X.
DR Bgee; FBgn0076973; Expressed in insect adult head and 1 other tissue.
DR GO; GO:0005887; C:integral component of plasma membrane; IC:UniProtKB.
DR GO; GO:0005283; F:amino acid:sodium symporter activity; ISS:UniProtKB.
DR GO; GO:0042943; F:D-amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IEA:EnsemblMetazoa.
DR GO; GO:0015175; F:neutral amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0042940; P:D-amino acid transport; ISS:UniProtKB.
DR GO; GO:0015804; P:neutral amino acid transport; ISS:UniProtKB.
DR GO; GO:0006814; P:sodium ion transport; ISS:UniProtKB.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616; PTHR11616; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SSF161070; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..653
FT /note="Sodium-dependent nutrient amino acid transporter 1"
FT /id="PRO_0000386586"
FT TOPO_DOM 1..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..373
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 459..479
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 486..506
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 528..548
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TRANSMEM 565..585
FT /note="Helical; Name=13"
FT /evidence="ECO:0000255"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 202
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 205
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 653 AA; 72810 MW; C2E89CBC9DF863BB CRC64;
MELKGVHQQN GTSNGTGAAG TEGESPPPAP APATAEAAAS LETTTEKVDA EQQKTERTNW
GNGLEFLMSC ISVSVGLGNV WRFPFTAYEN GGGAFLIPYI IVLFLIGKPM YYLEMIMGQF
TSQGTVKIWS VVPGFVGVGY GQAFATICII TYYSSLLALT LFYLFVSFQS VLPWSYCWEE
WMNCVDSRPQ EDTDALLLSS SNVTNVTALT DTVKLQSSSE LYFLNVVIKE KMDISDGIGD
PDWKLTLALF VSWVVIFLVI MRGVKSSGKA AYFLALFPYV VLFILLVRAV TLEGARDGII
FFLEPQWGEL LNPTVWKNAV VQCFFSLAVG SGPIIMFASY NRFDHGIYRD AMIVTTLDTL
TSLLGGITIF AILGNLAHNL QIENIRDVVR SGTGLAFISY PDAISKFQAV PQLFSVLFFF
MLFVLGIGSI VALQSTIVTI LCDQFKSWKY WKVALATSIC GFLMGLVYVT PGGQWILTLV
DFYGGTYVVF ILAIFELAGI VWIYGMQNFC DDVEFMCNRR VSLYWRVCWS FFTPVMMIVI
FIYSMVTIEP ITYSEQFFPE AGNVAGWLLF GIGAAQFPLW WMWYISHHRE GSLGQSFVAS
LRPSDKWGPA NPETKRQWVI FKNEKAAQRA TKKQSSKMGA FWQKLGHFCG SNT
