ID   NAAT1_DROSI             Reviewed;         643 AA.
AC   B4R4T6;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Sodium-dependent nutrient amino acid transporter 1 {ECO:0000250|UniProtKB:Q9W4C5};
GN   Name=NAAT1 {ECO:0000250|UniProtKB:Q9W4C5}; ORFNames=GD16262;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1] {ECO:0000312|EMBL:EDX17133.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC       cotransporter that promotes absorption of the D isomers of essential
CC       amino acids. Neutral amino acids are the preferred substrates,
CC       especially methionine and phenylalanine (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC       2.A.22) family. {ECO:0000305}.
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DR   EMBL; CM000366; EDX17133.1; -; Genomic_DNA.
DR   AlphaFoldDB; B4R4T6; -.
DR   SMR; B4R4T6; -.
DR   STRING; 7240.B4R4T6; -.
DR   HOGENOM; CLU_006855_9_5_1; -.
DR   OMA; WIYGLQN; -.
DR   PhylomeDB; B4R4T6; -.
DR   Proteomes; UP000000304; Chromosome x.
DR   GO; GO:0005887; C:integral component of plasma membrane; IC:UniProtKB.
DR   GO; GO:0005283; F:amino acid:sodium symporter activity; ISS:UniProtKB.
DR   GO; GO:0042943; F:D-amino acid transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IEA:EnsemblMetazoa.
DR   GO; GO:0015175; F:neutral amino acid transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0042940; P:D-amino acid transport; ISS:UniProtKB.
DR   GO; GO:0015804; P:neutral amino acid transport; ISS:UniProtKB.
DR   GO; GO:0006814; P:sodium ion transport; ISS:UniProtKB.
DR   InterPro; IPR000175; Na/ntran_symport.
DR   InterPro; IPR037272; SNS_sf.
DR   PANTHER; PTHR11616; PTHR11616; 1.
DR   Pfam; PF00209; SNF; 1.
DR   PRINTS; PR00176; NANEUSMPORT.
DR   SUPFAM; SSF161070; SSF161070; 1.
DR   PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR   PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR   PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Glycoprotein; Ion transport; Membrane;
KW   Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..643
FT                   /note="Sodium-dependent nutrient amino acid transporter 1"
FT                   /id="PRO_0000386587"
FT   TOPO_DOM        1..40
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..329
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        343..363
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        403..423
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        449..469
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        476..496
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        518..538
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        554..574
FT                   /note="Helical; Name=12"
FT                   /evidence="ECO:0000255"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        185
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        190
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        200
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   643 AA;  71913 MW;  053F69E8E54AAB8E CRC64;
     MELKGVQPSN GSPNGNGNGA TNAASTEKTD AEKPTAERTN WGNGLEFLMS CISVSVGLGN
     VWRFPFTAYE NGGGAFLIPY IIVLFLIGKP MYYLEMIMGQ FTSQGTVKIW SVVPGFVGVG
     YGQAFGTICI ISYYSSLLAL TLYYLFVSFQ SELPWSYCRD EWTNCVNSRP EEYVDNLLTG
     VSLANESARN LSGIGLVANN ETEKLQSSSE LYFLNVVIKE KLDISDGVGD PDWKLTLALF
     VAWVVIFLVI MRGVKSSGKA AYFLALFPYV VLFVLLIRAV TLEGARDGIL FFLEPQWGEL
     LNPTVWKEAV VQCFFSLAVG SGPIIMFASY NRFDHGIYRD AMIVTTLDTL TSLLGGITIF
     AILGNLAHNL QIENIRDVVR SGTGLAFISY PDAISKFQAV PQLFSVLFFF MLFVLGIGSI
     VALQSTIVTI ICDQFKGWKY WKVALTTSVC GFLMGLVYVT PGGQWILTLV DFYGGTYVVF
     ILAIFELAGI VWVYGLQNFC DDIEFMCNRR VSLYWRVCWS FFTPVMMIII FIYSMATIEP
     IKYSELYFPE AANVAGWLLF AIGAAQFPLW GLWYASRHPQ GTYWKSLKAS LKPSDRWGPA
     NPETRREWVI FKNQKAPQRA TQKDTSKLGF FWRKIANFCG SNK