NAAT1_DROVI
ID NAAT1_DROVI Reviewed; 637 AA.
AC B4MEG2;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Sodium-dependent nutrient amino acid transporter 1 {ECO:0000250|UniProtKB:Q9W4C5};
GN Name=NAAT1 {ECO:0000250|UniProtKB:Q9W4C5}; ORFNames=GJ14810;
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244;
RN [1] {ECO:0000312|EMBL:EDW62937.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000312|EMBL:EDW62937.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC cotransporter that promotes absorption of the D isomers of essential
CC amino acids. Neutral amino acids are the preferred substrates,
CC especially methionine and phenylalanine (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000305}.
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DR EMBL; CH940664; EDW62937.1; -; Genomic_DNA.
DR RefSeq; XP_002059515.1; XM_002059479.2.
DR AlphaFoldDB; B4MEG2; -.
DR SMR; B4MEG2; -.
DR STRING; 7244.FBpp0229227; -.
DR EnsemblMetazoa; FBtr0230735; FBpp0229227; FBgn0202014.
DR GeneID; 6636051; -.
DR KEGG; dvi:6636051; -.
DR eggNOG; KOG3660; Eukaryota.
DR HOGENOM; CLU_006855_9_5_1; -.
DR InParanoid; B4MEG2; -.
DR OMA; WIYGLQN; -.
DR OrthoDB; 250396at2759; -.
DR PhylomeDB; B4MEG2; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0005887; C:integral component of plasma membrane; IC:UniProtKB.
DR GO; GO:0005283; F:amino acid:sodium symporter activity; ISS:UniProtKB.
DR GO; GO:0042943; F:D-amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IEA:EnsemblMetazoa.
DR GO; GO:0015175; F:neutral amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0042940; P:D-amino acid transport; ISS:UniProtKB.
DR GO; GO:0015804; P:neutral amino acid transport; ISS:UniProtKB.
DR GO; GO:0006814; P:sodium ion transport; ISS:UniProtKB.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616; PTHR11616; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SSF161070; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..637
FT /note="Sodium-dependent nutrient amino acid transporter 1"
FT /id="PRO_0000386588"
FT TOPO_DOM 1..47
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 397..417
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 443..463
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 470..490
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 515..535
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 549..569
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 181
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 637 AA; 71468 MW; 106E89220125E3D7 CRC64;
MELKTMPQNG ANAGTQHNNN SNNKPDNNEK EAQKKEPERT NWSNGLEFLM SCISVSVGLG
NVWRFPFTAY ENGGGAFLIP YIIVLFLIGK PMYYLEMIIG QFTSQGTVKI WSICPSFMGV
GYGQAFATIC IITYYSSLLA LTVYYLFVSF QSELPWSYCR DDWVNCVNSR PAEYVETLLT
NASSALSRAT ESATNVTKLQ SSSELYFLNV VIKEKSDITD GIGAPDWKLT IALFVSWVVI
FLVIMRGVKS SGKAAYFLAL FPYVVLFALL GRAVTLEGAV DGIIFFLQPQ WGELLNPIVW
KEAVVQCFFS LAVGCGPIIM FASYNRFDHG IYRDAMIVTT LDTLTSLLGG ITIFAILGNL
AHNLKVDNIR DVVRSGTGLA FISYPDAISK FQAVPQLFSA LFFFMLFVLG IGSIVALQST
IVTIICDQFK TCKYWKVAMA TSICGFLMGL VYVTPGGQWI LTLVDFYGGT YVVFILAIFE
LAGIVWIYGL QNFCDDIEFM SNKKVSLYWR ICWSFFTPIM MIVIFIYSMV TISPIKYSDT
YFPVAGDVAG WVLFAVGAAQ FPLWGWWYIR THRHDSFSKS FMASLKPSEK WGPSNPETRR
DWLLFKSDLA AKRAIQAKSN KMGFFRQKLY NLCGNSN
