NAAT1_DROWI
ID NAAT1_DROWI Reviewed; 641 AA.
AC B4NDL8;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Sodium-dependent nutrient amino acid transporter 1 {ECO:0000250|UniProtKB:Q9W4C5};
GN Name=NAAT1 {ECO:0000250|UniProtKB:Q9W4C5}; ORFNames=GK25473;
OS Drosophila willistoni (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7260;
RN [1] {ECO:0000312|EMBL:EDW81840.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14030-0811.24 {ECO:0000312|EMBL:EDW81840.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC cotransporter that promotes absorption of the D isomers of essential
CC amino acids. Neutral amino acids are the preferred substrates,
CC especially methionine and phenylalanine (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH964239; EDW81840.1; -; Genomic_DNA.
DR RefSeq; XP_002070854.1; XM_002070818.2.
DR AlphaFoldDB; B4NDL8; -.
DR SMR; B4NDL8; -.
DR STRING; 7260.FBpp0254616; -.
DR EnsemblMetazoa; FBtr0256124; FBpp0254616; FBgn0227432.
DR GeneID; 6648386; -.
DR KEGG; dwi:6648386; -.
DR eggNOG; KOG3660; Eukaryota.
DR HOGENOM; CLU_006855_9_5_1; -.
DR InParanoid; B4NDL8; -.
DR OMA; WIYGLQN; -.
DR OrthoDB; 250396at2759; -.
DR PhylomeDB; B4NDL8; -.
DR Proteomes; UP000007798; Unassembled WGS sequence.
DR GO; GO:0005887; C:integral component of plasma membrane; IC:UniProtKB.
DR GO; GO:0005283; F:amino acid:sodium symporter activity; ISS:UniProtKB.
DR GO; GO:0042943; F:D-amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015175; F:neutral amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0042940; P:D-amino acid transport; ISS:UniProtKB.
DR GO; GO:0015804; P:neutral amino acid transport; ISS:UniProtKB.
DR GO; GO:0006814; P:sodium ion transport; ISS:UniProtKB.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616; PTHR11616; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SSF161070; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..641
FT /note="Sodium-dependent nutrient amino acid transporter 1"
FT /id="PRO_0000386589"
FT TOPO_DOM 1..38
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..361
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 474..494
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 516..536
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 552..572
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 181
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 641 AA; 71796 MW; 6D8C2C9B7CE2D953 CRC64;
MELKNIEQQP QLQNGNGTAT ENNEKGEQKP TEGGERTNWG NGLEFLMSCI SVSVGLGNVW
RFPFTAYENG GGAFLIPYII VLFLIGKPMY YLEMIIGQFT SQGSVKIWSI CPSFLGVGYG
QAFATVCIIS YYSSLLALTL YYLFVSFQSV LPWSYCRDEW TNCVNSRPED YSSTMLEAAR
NATSSLLIGN ETTSLADNDS VQLQSSSELY FLNVVIKEKL DISDGVGAPD WKLTLALLVS
WIVTFLVIMR GVKSSGKAAY FLAIFPYVVL FVLLGRAVTL EGAVDGIIFF LQPQWGELLN
PTVWKEAVVQ CFFSLAVSCG PIIMFASYNR FDHSIYRDAM IVTTLDTLTS LLGGITIFAI
LGNLAHNLQV DNIREVVRSG TGLAFISYPD AISKFQAVPQ LFSVLFFFML FVLGIGSIVA
LQSTIVTIIC DQFKSWKYWK VALVTSICGF LLGLVYVTPG GQWILTLVDF YGGTYVVFIL
AIFELAGIVW IYGLQNFCDD IEFMCNKRVS LYWRVCWSFF TPVMMIIIFI YSMATIEPLK
YSDLYFPLAG DIAGWIVFAI GTAQFPLWGI WYISHHRNGN LWQSFVSCLK PNENWGPANP
ETKQAWLLFK SEKARQRASK TQSSKMGQFW QKVGNFCGSS T
