NAAT1_DROYA
ID NAAT1_DROYA Reviewed; 641 AA.
AC B4PZQ4;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Sodium-dependent nutrient amino acid transporter 1 {ECO:0000250|UniProtKB:Q9W4C5};
GN Name=NAAT1 {ECO:0000250|UniProtKB:Q9W4C5}; ORFNames=GE16816;
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1] {ECO:0000312|EMBL:EDX01121.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01 {ECO:0000312|EMBL:EDX01121.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC cotransporter that promotes absorption of the D isomers of essential
CC amino acids. Neutral amino acids are the preferred substrates,
CC especially methionine and phenylalanine (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000305}.
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DR EMBL; CM000162; EDX01121.1; -; Genomic_DNA.
DR RefSeq; XP_002100013.1; XM_002099977.2.
DR AlphaFoldDB; B4PZQ4; -.
DR SMR; B4PZQ4; -.
DR STRING; 7245.FBpp0261826; -.
DR EnsemblMetazoa; FBtr0263334; FBpp0261826; FBgn0234308.
DR GeneID; 6524150; -.
DR KEGG; dya:Dyak_GE16816; -.
DR eggNOG; KOG3660; Eukaryota.
DR HOGENOM; CLU_006855_9_5_1; -.
DR OMA; WIYGLQN; -.
DR OrthoDB; 250396at2759; -.
DR PhylomeDB; B4PZQ4; -.
DR Proteomes; UP000002282; Chromosome X.
DR GO; GO:0005887; C:integral component of plasma membrane; IC:UniProtKB.
DR GO; GO:0005283; F:amino acid:sodium symporter activity; ISS:UniProtKB.
DR GO; GO:0042943; F:D-amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IEA:EnsemblMetazoa.
DR GO; GO:0015175; F:neutral amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0042940; P:D-amino acid transport; ISS:UniProtKB.
DR GO; GO:0015804; P:neutral amino acid transport; ISS:UniProtKB.
DR GO; GO:0006814; P:sodium ion transport; ISS:UniProtKB.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616; PTHR11616; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SSF161070; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Glycoprotein; Ion transport; Membrane; Sodium;
KW Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..641
FT /note="Sodium-dependent nutrient amino acid transporter 1"
FT /id="PRO_0000386590"
FT TOPO_DOM 1..38
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..361
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 474..494
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 516..536
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 552..572
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 641 AA; 71688 MW; 331F5B25EDCA52A2 CRC64;
MELKGVQPSN GSANGNGTTN AASTEKADTE KQTAERTNWG NGLEFLMSCI SVSVGLGNVW
RFPFTAYENG GGAFLIPYII VLFLIGKPMY YLEMIMGQFT SQGTVKIWSV VPGFVGVGYG
QAFGTICIIS YYSSLLALTL YYLFVSFQSE LPWSYCRDEW TNCVNSRPQE YVDNLLTGVS
LANESARNLS GIGFVANDET EKLQSSSELY FLNVVIKEKL DISDGVGDPD WKLTLALFVA
WVVIFLVIMR GVKSSGKAAY FLALFPYVVL FVLLIRAVTL EGARDGILFF LEPQWGELLN
PTVWKEAVVQ CFFSLAVGSG PIIMFASYNR FDHGIYRDAM IVTTLDTLTS LLGGITIFAI
LGNLAHNLQI ENIRDVVRSG TGLAFISYPD AISKFQAVPQ LFSVLFFFML FVLGIGSIVA
LQSTIVTIIC DQFKGLKYWK VALITSACGF LMGLVYVTPG GQWILTLVDF YGGTYVVFIL
AIFELAGIVW VYGLQNFCDD IEFMCNRRVS LYWRMCWSFF TPVMMIIIFI YSMATIEPIK
YSELYFPEAA NIAGWLLFAI GAAQFPLWGL WYASTHPQGT YWKSLKASLK PSDRWGPANP
ETRREWVIFK NQKAAQRATQ KSTSKLGFFW RKLTNFCGSN K
