ID   A16A1_RAT               Reviewed;         802 AA.
AC   Q3T1L0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Aldehyde dehydrogenase family 16 member A1;
GN   Name=Aldh16a1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Interacts with SPG21. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: The active site cysteine and glutamate residues are not
CC       conserved in this protein. Its activity is therefore unsure.
CC       {ECO:0000305}.
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DR   EMBL; BC101860; AAI01861.1; -; mRNA.
DR   RefSeq; NP_001028878.1; NM_001033706.1.
DR   AlphaFoldDB; Q3T1L0; -.
DR   SMR; Q3T1L0; -.
DR   IntAct; Q3T1L0; 7.
DR   STRING; 10116.ENSRNOP00000027992; -.
DR   iPTMnet; Q3T1L0; -.
DR   PhosphoSitePlus; Q3T1L0; -.
DR   jPOST; Q3T1L0; -.
DR   PaxDb; Q3T1L0; -.
DR   PRIDE; Q3T1L0; -.
DR   GeneID; 361571; -.
DR   KEGG; rno:361571; -.
DR   UCSC; RGD:1566295; rat.
DR   CTD; 126133; -.
DR   RGD; 1566295; Aldh16a1.
DR   VEuPathDB; HostDB:ENSRNOG00000020623; -.
DR   eggNOG; KOG2450; Eukaryota.
DR   HOGENOM; CLU_018339_0_0_1; -.
DR   InParanoid; Q3T1L0; -.
DR   OMA; MDYGPAP; -.
DR   OrthoDB; 1070579at2759; -.
DR   PhylomeDB; Q3T1L0; -.
DR   TreeFam; TF329461; -.
DR   PRO; PR:Q3T1L0; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000020623; Expressed in kidney and 19 other tissues.
DR   ExpressionAtlas; Q3T1L0; baseline and differential.
DR   Genevisible; Q3T1L0; RN.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 2.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR011408; Aldehyde_DH.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF211; PTHR11699:SF211; 2.
DR   Pfam; PF00171; Aldedh; 2.
DR   PIRSF; PIRSF036490; Aldedh_dupl; 1.
DR   SUPFAM; SSF53720; SSF53720; 2.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..802
FT                   /note="Aldehyde dehydrogenase family 16 member A1"
FT                   /id="PRO_0000312988"
FT   REGION          513..554
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        536..551
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   802 AA;  85414 MW;  44CAC35754443929 CRC64;
     MAATRIQPST REIFTTLEYG PVPESHACAL AWLDTHNRLL GHYVNGMWLK PEHRNPAPCQ
     DPITGENLAS CLQAEAEDIS AAVEAARITF KTWSQLPGTA RGQHLTRLAK VIQKHQRLLW
     TLESLVTGRA VREVRDGDIP LAQQLLHYHA LQAHAQDSAL ADWEPLGVIG LILPTSFSFL
     DMMWRVCPAL AMGCTVVALV PPSFPTPLLL AQLAGELGSF PGILNVVCGP VSLGPVLASQ
     PGVQKVAFCG AVEEGRALRQ TLAGRGATLG LALGTESLLL LTDSADVDSA VEGVVDAVWS
     DRSLGGLRLL IQESVWDEAM KRLQARMAQI RSGKGLDGAV DMGARGAAAR DLAQSFVDEA
     QSQGGQVFQA GDMPSNSPFF SPTLVSGLPP AAPCAQAEVP WPVVMASPFR TVKEALALAN
     GTPRGGSASV WSERLGQALE LGYGLQVGTV WINAHGLRDP AVPTGGCKES GSSWHGGPDG
     LYEYLQLLGT PYRESFLCES LNYDTFGLAV SSSLPSGPET GPSPAPPYGL FVRGRFQSPG
     TQSSRPIKDS SGKVSSYVAE GGAKDIRGAV EAAHQAAPGW GAQSPRARAS LLWALAAALE
     RRKQVLAAQL ERHGAAPTVA ETEVELSVRR LQTWATRVQD QGQTLQVTGL RGPVLRLREP
     LGVLAVVCPD EWPMLAFVSL LAPALAHGNA VVLVPSGSCP LLALEACQDI AALFPAGLVN
     VVTGDRDHLT RCLALHQDVQ AMWYFGSAQG SQFVEWASAG NLKPVWVNRD FPRAWDVEVQ
     GSEQELSLHA ARTKALWLPM GD