NAC13_ARATH
ID NAC13_ARATH Reviewed; 528 AA.
AC F4IED2; Q94CC7; Q9MAQ1;
DT 01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=NAC domain-containing protein 13 {ECO:0000303|PubMed:15029955};
DE Short=ANAC013 {ECO:0000303|PubMed:15029955};
DE AltName: Full=Protein NTM1-like 1 {ECO:0000303|PubMed:17158162};
GN Name=NAC013 {ECO:0000312|EMBL:AEE31534.1};
GN Synonyms=NTL1 {ECO:0000303|PubMed:17158162};
GN OrderedLocusNames=At1g32870 {ECO:0000312|Araport:AT1G32870};
GN ORFNames=F9L11.7 {ECO:0000312|EMBL:AAF31294.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15029955; DOI=10.1093/dnares/10.6.239;
RA Ooka H., Satoh K., Doi K., Nagata T., Otomo Y., Murakami K., Matsubara K.,
RA Osato N., Kawai J., Carninci P., Hayashizaki Y., Suzuki K., Kojima K.,
RA Takahara Y., Yamamoto K., Kikuchi S.;
RT "Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis
RT thaliana.";
RL DNA Res. 10:239-247(2003).
RN [5]
RP GENE FAMILY, NOMENCLATURE, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=17158162; DOI=10.1093/nar/gkl1068;
RA Kim S.Y., Kim S.G., Kim Y.S., Seo P.J., Bae M., Yoon H.K., Park C.M.;
RT "Exploring membrane-associated NAC transcription factors in Arabidopsis:
RT implications for membrane biology in genome regulation.";
RL Nucleic Acids Res. 35:203-213(2007).
RN [6]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=24045019; DOI=10.1105/tpc.113.117168;
RA De Clercq I., Vermeirssen V., Van Aken O., Vandepoele K., Murcha M.W.,
RA Law S.R., Inze A., Ng S., Ivanova A., Rombaut D., van de Cotte B.,
RA Jaspers P., Van de Peer Y., Kangasjaervi J., Whelan J., Van Breusegem F.;
RT "The membrane-bound NAC transcription factor ANAC013 functions in
RT mitochondrial retrograde regulation of the oxidative stress response in
RT Arabidopsis.";
RL Plant Cell 25:3472-3490(2013).
RN [7]
RP INTERACTION WITH RCD1.
RX PubMed=25348421; DOI=10.1042/bj20141045;
RA O'Shea C., Kryger M., Stender E.G., Kragelund B.B., Willemoes M.,
RA Skriver K.;
RT "Protein intrinsic disorder in Arabidopsis NAC transcription factors:
RT transcriptional activation by ANAC013 and ANAC046 and their interactions
RT with RCD1.";
RL Biochem. J. 465:281-294(2015).
CC -!- FUNCTION: Transcriptional activator activated by proteolytic cleavage
CC through regulated intramembrane proteolysis (RIP). Involved in
CC oxidative stress tolerance by mediating regulation of mitochondrial
CC retrograde signaling during mitochondrial dysfunction. Interacts
CC directly with the mitochondrial dysfunction DNA consensus motif 5'-
CC CTTGNNNNNCA[AC]G-3', a cis-regulatory elements of several mitochondrial
CC retrograde regulation-induced genes, and triggers increased oxidative
CC stress tolerance. {ECO:0000269|PubMed:24045019}.
CC -!- SUBUNIT: Interacts with RCD1. {ECO:0000269|PubMed:25348421}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:24045019}; Single-pass membrane protein
CC {ECO:0000255}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353,
CC ECO:0000269|PubMed:24045019}. Note=Localized primarily in endoplasmic
CC reticulum membrane as dormant form and, upon oxidative stress, is
CC processed into a transcriptionally active and nuclear form after a
CC proteolytic cleavage through regulated intramembrane proteolysis (RIP).
CC {ECO:0000269|PubMed:24045019}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences. {ECO:0000305};
CC Name=1;
CC IsoId=F4IED2-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed in roots, rosette leaves, shoot apex,
CC stems and flowers. {ECO:0000269|PubMed:17158162}.
CC -!- INDUCTION: By heat, salt stress, abscisic acid (ABA) and methyl
CC methanesulfonate (MMS) treatment. {ECO:0000269|PubMed:17158162}.
CC -!- DOMAIN: The NAC domain includes a DNA binding domain and a dimerization
CC domain. {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF31294.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AEE31535.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC006424; AAF31294.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE31534.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31535.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AY034959; AAK59465.1; -; mRNA.
DR PIR; E86453; E86453.
DR RefSeq; NP_001117401.1; NM_001123929.1.
DR RefSeq; NP_564410.1; NM_103021.4. [F4IED2-1]
DR AlphaFoldDB; F4IED2; -.
DR SMR; F4IED2; -.
DR IntAct; F4IED2; 1.
DR STRING; 3702.AT1G32870.1; -.
DR PaxDb; F4IED2; -.
DR ProteomicsDB; 251232; -. [F4IED2-1]
DR EnsemblPlants; AT1G32870.1; AT1G32870.1; AT1G32870. [F4IED2-1]
DR GeneID; 840181; -.
DR Gramene; AT1G32870.1; AT1G32870.1; AT1G32870. [F4IED2-1]
DR KEGG; ath:AT1G32870; -.
DR Araport; AT1G32870; -.
DR TAIR; locus:2037925; AT1G32870.
DR eggNOG; ENOG502QT9T; Eukaryota.
DR InParanoid; F4IED2; -.
DR PRO; PR:F4IED2; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4IED2; baseline and differential.
DR Genevisible; F4IED2; AT.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0031930; P:mitochondria-nucleus signaling pathway; IDA:UniProtKB.
DR GO; GO:1900409; P:positive regulation of cellular response to oxidative stress; IDA:UniProtKB.
DR GO; GO:0010114; P:response to red light; IEP:TAIR.
DR GO; GO:0010224; P:response to UV-B; IEP:TAIR.
DR Gene3D; 2.170.150.80; -; 1.
DR InterPro; IPR003441; NAC-dom.
DR InterPro; IPR036093; NAC_dom_sf.
DR Pfam; PF02365; NAM; 1.
DR SUPFAM; SSF101941; SSF101941; 1.
DR PROSITE; PS51005; NAC; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; DNA-binding; Endoplasmic reticulum;
KW Membrane; Nucleus; Reference proteome; Stress response; Transcription;
KW Transcription regulation; Transmembrane; Transmembrane helix.
FT CHAIN 1..528
FT /note="NAC domain-containing protein 13"
FT /id="PRO_0000432440"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 10..160
FT /note="NAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT DNA_BIND 107..166
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT REGION 388..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 272
FT /note="E -> G (in Ref. 3; AAK59465)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 528 AA; 59322 MW; 02C93E78A2F10432 CRC64;
MDLSVENGGL APGFRFHPTD EELVVYYLKR KIRRKKLRVE AIGETDVYKF DPEELPEKAL
YKTRDRQWFF FSLRDRKHGS RSSRATERGY WKATGKDRVI HCDSRPVGEK KTLVFHRGRA
PNGERTNWVM HEYTLHKEEL KRCGGEDVKD AYVLYKIYKK SGSGPKNGEQ YGAPFIEEEW
AEDDDDDVDE PANQLVVSAS VDNSLWGKGL NQSELDDNDI EELMSQVRDQ SGPTLQQNGV
SGLNSHVDTY NLENLEEDMY LEINDLMEPE PEPTSVEVME NNWNEDGSGL LNDDDFVGAD
SYFLDLGVTN PQLDFVSGDL KNGFAQSLQV NTSLMTYQAN NNQFQQQSGK NQASNWPLRN
SYTRQINNGS SWVQELNNDG LTVTRFGEAP GTGDSSEFLN PVPSGISTTN EDDPSKDESS
KFASSVWTFL ESIPAKPAYA SENPFVKLNL VRMSTSGGRF RFTSKSTGNN VVVMDSDSAV
KRNKSGGNND KKKKKNKGFF CLSIIGALCA LFWVIIGTMG GSGRPLLW