NAC17_ARATH
ID NAC17_ARATH Reviewed; 557 AA.
AC Q9XIC5;
DT 01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 25-MAY-2022, entry version 133.
DE RecName: Full=NAC domain-containing protein 17 {ECO:0000303|PubMed:15029955};
DE Short=ANAC017 {ECO:0000303|PubMed:15029955};
DE AltName: Full=Protein NTM1-like 7 {ECO:0000303|PubMed:17158162};
DE AltName: Full=Protein REGULATORS OF AOX1A 2 {ECO:0000303|PubMed:24045017};
GN Name=NAC017 {ECO:0000312|EMBL:AEE31684.1};
GN Synonyms=NTL7 {ECO:0000303|PubMed:17158162},
GN RAO2 {ECO:0000303|PubMed:24045017};
GN OrderedLocusNames=At1g34190 {ECO:0000312|Araport:AT1G34190};
GN ORFNames=F23M19.13 {ECO:0000312|EMBL:AAD39612.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15029955; DOI=10.1093/dnares/10.6.239;
RA Ooka H., Satoh K., Doi K., Nagata T., Otomo Y., Murakami K., Matsubara K.,
RA Osato N., Kawai J., Carninci P., Hayashizaki Y., Suzuki K., Kojima K.,
RA Takahara Y., Yamamoto K., Kikuchi S.;
RT "Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis
RT thaliana.";
RL DNA Res. 10:239-247(2003).
RN [5]
RP GENE FAMILY, NOMENCLATURE, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=17158162; DOI=10.1093/nar/gkl1068;
RA Kim S.Y., Kim S.G., Kim Y.S., Seo P.J., Bae M., Yoon H.K., Park C.M.;
RT "Exploring membrane-associated NAC transcription factors in Arabidopsis:
RT implications for membrane biology in genome regulation.";
RL Nucleic Acids Res. 35:203-213(2007).
RN [6]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=24045017; DOI=10.1105/tpc.113.113985;
RA Ng S., Ivanova A., Duncan O., Law S.R., Van Aken O., De Clercq I., Wang Y.,
RA Carrie C., Xu L., Kmiec B., Walker H., Van Breusegem F., Whelan J.,
RA Giraud E.;
RT "A membrane-bound NAC transcription factor, ANAC017, mediates mitochondrial
RT retrograde signaling in Arabidopsis.";
RL Plant Cell 25:3450-3471(2013).
CC -!- FUNCTION: Transcriptional activator activated by proteolytic cleavage
CC through regulated intramembrane proteolysis (RIP). Transcriptional
CC activator that acts as positive regulator of AOX1A during mitochondrial
CC dysfunction. Binds directly to AOX1A promoter. Mediates mitochondrial
CC retrograde signaling. {ECO:0000269|PubMed:24045017}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:24045017}; Single-pass membrane protein
CC {ECO:0000255}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353,
CC ECO:0000269|PubMed:24045017}. Note=Localized primarily in endoplasmic
CC reticulum membrane as dormant form and, upon abiotic stress, is
CC processed into a transcriptionally active and nuclear form after a
CC proteolytic cleavage through regulated intramembrane proteolysis (RIP).
CC {ECO:0000269|PubMed:24045017}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, rosette leaves, cauline leaves,
CC shoot apex, stems and flowers. {ECO:0000269|PubMed:17158162}.
CC -!- INDUCTION: By cold and drought stresses. {ECO:0000269|PubMed:17158162}.
CC -!- DOMAIN: The NAC domain includes a DNA binding domain and a dimerization
CC domain. {ECO:0000255|PROSITE-ProRule:PRU00353}.
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DR EMBL; AC007454; AAD39612.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31684.1; -; Genomic_DNA.
DR EMBL; AF361813; AAK32826.1; -; mRNA.
DR EMBL; AY133552; AAM91382.1; -; mRNA.
DR EMBL; BT000730; AAN31872.1; -; mRNA.
DR PIR; B86466; B86466.
DR RefSeq; NP_564440.1; NM_103142.4.
DR AlphaFoldDB; Q9XIC5; -.
DR SMR; Q9XIC5; -.
DR STRING; 3702.AT1G34190.1; -.
DR iPTMnet; Q9XIC5; -.
DR PaxDb; Q9XIC5; -.
DR PRIDE; Q9XIC5; -.
DR ProteomicsDB; 251266; -.
DR EnsemblPlants; AT1G34190.1; AT1G34190.1; AT1G34190.
DR GeneID; 840318; -.
DR Gramene; AT1G34190.1; AT1G34190.1; AT1G34190.
DR KEGG; ath:AT1G34190; -.
DR Araport; AT1G34190; -.
DR TAIR; locus:2009096; AT1G34190.
DR eggNOG; ENOG502QT9T; Eukaryota.
DR HOGENOM; CLU_030918_1_0_1; -.
DR InParanoid; Q9XIC5; -.
DR OMA; MEPIDQG; -.
DR OrthoDB; 659212at2759; -.
DR PhylomeDB; Q9XIC5; -.
DR PRO; PR:Q9XIC5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9XIC5; baseline and differential.
DR Genevisible; Q9XIC5; AT.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0070301; P:cellular response to hydrogen peroxide; IMP:UniProtKB.
DR GO; GO:0010150; P:leaf senescence; IMP:TAIR.
DR GO; GO:0031930; P:mitochondria-nucleus signaling pathway; IMP:TAIR.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:TAIR.
DR Gene3D; 2.170.150.80; -; 1.
DR InterPro; IPR003441; NAC-dom.
DR InterPro; IPR036093; NAC_dom_sf.
DR Pfam; PF02365; NAM; 1.
DR SUPFAM; SSF101941; SSF101941; 1.
DR PROSITE; PS51005; NAC; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Endoplasmic reticulum; Membrane; Nucleus;
KW Reference proteome; Stress response; Transcription;
KW Transcription regulation; Transmembrane; Transmembrane helix.
FT CHAIN 1..557
FT /note="NAC domain-containing protein 17"
FT /id="PRO_0000432443"
FT TRANSMEM 526..546
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 16..166
FT /note="NAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT DNA_BIND 115..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
SQ SEQUENCE 557 AA; 62587 MW; 312B1DC10CEBAB59 CRC64;
MADSSPDSCF KGGKFSAPGF RFHPTDEELV MYYLKRKICR KRLRVNVIGV VDVYKMDPEE
LPGQSMLKTG DRQWFYFTPR SRKYPNAARS NRGTENGYWK ATGKDRVIEY NSRSVGLKKT
LVFYRGRAPS GERTDWVMHE YTMDEDELGR CKNPQEYYAL YKLFKKSGAG PKNGEQYGAP
FQEEEWVDDD NEDVNAIAVA VPEQPVVRYE DARRVDERRL FNPVILQLED IDELLNGIPN
APGVPQRCIP QVNSEEELQS TLVNNSAREF LPNGQQYNRP SSFDSLETAE VTSAPLVFEK
EDFIEMDDLL LIPEFGASST EKAAQFSNHG EFDDFNEFDQ LFHDVSMSLD MEPIDQGTSA
NLSSLSDSAN YTSDQKQQLL YQQFQDQTPE NQLNNIMDPS TTLNQITSDI WFEDDQAILF
DQQQSFSGAF ASPSSGVMPD STNPTMSVNA QGHEIQNGGG TTSQFSSALW ALMDSIPSTP
ASACEGPLNR TFVRMSSFSR MRFNGKANGT PVSTTIAKKG IRNRGFLLLS IVGALCAIFW
VLVATVRVSG RSLLLKD
