NAC18_ARATH
ID NAC18_ARATH Reviewed; 320 AA.
AC Q9ZNU2; Q8LDB9; Q8LPH5;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=NAC domain-containing protein 18;
DE Short=ANAC018;
DE AltName: Full=Protein NAC-REGULATED SEED MORPHOLOGY 2 {ECO:0000303|PubMed:18849494};
DE AltName: Full=Protein NO APICAL MERISTEM;
DE Short=AtNAM;
GN Name=NAC018; Synonyms=NAM, NARS2 {ECO:0000303|PubMed:18849494};
GN OrderedLocusNames=At1g52880; ORFNames=F14G24.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=12175016; DOI=10.1023/a:1016028530943;
RA Duval M., Hsieh T.-F., Kim S.Y., Thomas T.L.;
RT "Molecular characterization of AtNAM: a member of the Arabidopsis NAC
RT domain superfamily.";
RL Plant Mol. Biol. 50:237-248(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15029955; DOI=10.1093/dnares/10.6.239;
RA Ooka H., Satoh K., Doi K., Nagata T., Otomo Y., Murakami K., Matsubara K.,
RA Osato N., Kawai J., Carninci P., Hayashizaki Y., Suzuki K., Kojima K.,
RA Takahara Y., Yamamoto K., Kikuchi S.;
RT "Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis
RT thaliana.";
RL DNA Res. 10:239-247(2003).
RN [7]
RP FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=18849494; DOI=10.1105/tpc.108.060160;
RA Kunieda T., Mitsuda N., Ohme-Takagi M., Takeda S., Aida M., Tasaka M.,
RA Kondo M., Nishimura M., Hara-Nishimura I.;
RT "NAC family proteins NARS1/NAC2 and NARS2/NAM in the outer integument
RT regulate embryogenesis in Arabidopsis.";
RL Plant Cell 20:2631-2642(2008).
CC -!- FUNCTION: May encode a transcription factor involved in the elaboration
CC of shoot apical meristems (SAM) (Probable). Together with NAC056/NARS1,
CC regulates embryogenesis by regulating the development and degeneration
CC of ovule integuments, a process required for intertissue communication
CC between the embryo and the maternal integument (PubMed:18849494).
CC {ECO:0000269|PubMed:18849494, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18849494}.
CC -!- TISSUE SPECIFICITY: Restricted primarily to the region of the embryo
CC including the SAM (PubMed:12175016). Expressed in the outer integument,
CC but seems not expressed in the embryo at the torpedo stage
CC (PubMed:18849494). {ECO:0000269|PubMed:12175016,
CC ECO:0000269|PubMed:18849494}.
CC -!- DOMAIN: The NAC domain includes a DNA binding domain and a dimerization
CC domain. {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC -!- DISRUPTION PHENOTYPE: When associated with disruption in NAC056/NARS1,
CC abnormally shaped seeds, defect in embryogenesis arrested at the
CC torpedo-shaped embryo stage, markedly delayed integuments degeneration,
CC and delay of silique senescence. {ECO:0000269|PubMed:18849494}.
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DR EMBL; AF123310; AAD17313.1; -; Genomic_DNA.
DR EMBL; AF123311; AAD17314.1; -; mRNA.
DR EMBL; AC019018; AAG52280.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32863.1; -; Genomic_DNA.
DR EMBL; AY099786; AAM20637.1; -; mRNA.
DR EMBL; BT000292; AAN15611.1; -; mRNA.
DR EMBL; AY086093; AAM63301.1; -; mRNA.
DR PIR; A96570; A96570.
DR RefSeq; NP_175696.1; NM_104166.3.
DR AlphaFoldDB; Q9ZNU2; -.
DR SMR; Q9ZNU2; -.
DR BioGRID; 26946; 13.
DR STRING; 3702.AT1G52880.1; -.
DR iPTMnet; Q9ZNU2; -.
DR PaxDb; Q9ZNU2; -.
DR PRIDE; Q9ZNU2; -.
DR ProteomicsDB; 251233; -.
DR EnsemblPlants; AT1G52880.1; AT1G52880.1; AT1G52880.
DR GeneID; 841721; -.
DR Gramene; AT1G52880.1; AT1G52880.1; AT1G52880.
DR KEGG; ath:AT1G52880; -.
DR Araport; AT1G52880; -.
DR TAIR; locus:2011516; AT1G52880.
DR eggNOG; ENOG502QRBC; Eukaryota.
DR HOGENOM; CLU_035664_8_1_1; -.
DR InParanoid; Q9ZNU2; -.
DR OMA; KPTHICD; -.
DR OrthoDB; 1189960at2759; -.
DR PhylomeDB; Q9ZNU2; -.
DR PRO; PR:Q9ZNU2; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9ZNU2; baseline and differential.
DR Genevisible; Q9ZNU2; AT.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0080060; P:integument development; IMP:UniProtKB.
DR GO; GO:0045995; P:regulation of embryonic development; IMP:UniProtKB.
DR GO; GO:0048317; P:seed morphogenesis; IMP:UniProtKB.
DR GO; GO:0048731; P:system development; IBA:GO_Central.
DR Gene3D; 2.170.150.80; -; 1.
DR InterPro; IPR003441; NAC-dom.
DR InterPro; IPR036093; NAC_dom_sf.
DR Pfam; PF02365; NAM; 1.
DR SUPFAM; SSF101941; SSF101941; 1.
DR PROSITE; PS51005; NAC; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..320
FT /note="NAC domain-containing protein 18"
FT /id="PRO_0000132308"
FT DOMAIN 17..177
FT /note="NAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT DNA_BIND 118..183
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 206
FT /note="D -> G (in Ref. 4; AAM20637/AAN15611)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 320 AA; 35443 MW; B8E4C947F716E331 CRC64;
MESTDSSGGP PPPQPNLPPG FRFHPTDEEL VIHYLKRKAD SVPLPVAIIA DVDLYKFDPW
ELPAKASFGE QEWYFFSPRD RKYPNGARPN RAATSGYWKA TGTDKPVIST GGGGSKKVGV
KKALVFYSGK PPKGVKSDWI MHEYRLTDNK PTHICDFGNK KNSLRLDDWV LCRIYKKNNS
TASRHHHHLH HIHLDNDHHR HDMMIDDDRF RHVPPGLHFP AIFSDNNDPT AIYDGGGGGY
GGGSYSMNHC FASGSKQEQL FPPVMMMTSL NQDSGIGSSS SPSKRFNGGG VGDCSTSMAA
TPLMQNQGGI YQLPGLNWYS
