NAC1_ARATH
ID NAC1_ARATH Reviewed; 429 AA.
AC Q0WV96; Q944A1; Q9MAN3;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 2.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=NAC domain-containing protein 1 {ECO:0000303|PubMed:15029955};
DE Short=ANAC001 {ECO:0000303|PubMed:15029955};
DE AltName: Full=Protein NTM1-like 10 {ECO:0000303|PubMed:17158162};
GN Name=NAC001 {ECO:0000312|EMBL:AEE27216.1};
GN Synonyms=NTL10 {ECO:0000303|PubMed:17158162}; OrderedLocusNames=At1g01010;
GN ORFNames=T25K16.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15029955; DOI=10.1093/dnares/10.6.239;
RA Ooka H., Satoh K., Doi K., Nagata T., Otomo Y., Murakami K., Matsubara K.,
RA Osato N., Kawai J., Carninci P., Hayashizaki Y., Suzuki K., Kojima K.,
RA Takahara Y., Yamamoto K., Kikuchi S.;
RT "Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis
RT thaliana.";
RL DNA Res. 10:239-247(2003).
RN [6]
RP GENE FAMILY, NOMENCLATURE, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=17158162; DOI=10.1093/nar/gkl1068;
RA Kim S.Y., Kim S.G., Kim Y.S., Seo P.J., Bae M., Yoon H.K., Park C.M.;
RT "Exploring membrane-associated NAC transcription factors in Arabidopsis:
RT implications for membrane biology in genome regulation.";
RL Nucleic Acids Res. 35:203-213(2007).
CC -!- FUNCTION: Transcriptional activator activated by proteolytic cleavage
CC through regulated intramembrane proteolysis (RIP).
CC {ECO:0000250|UniProtKB:Q949N0}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q949N0}; Single-
CC pass membrane protein {ECO:0000255}. Nucleus
CC {ECO:0000250|UniProtKB:Q949N0, ECO:0000255|PROSITE-ProRule:PRU00353}.
CC Note=Localized primarily in plasma membrane or endoplasmic reticulum
CC membrane as dormant form and, upon specific stress or signal, is
CC processed into a transcriptionally active and nuclear form after a
CC proteolytic cleavage through regulated intramembrane proteolysis (RIP).
CC {ECO:0000250|UniProtKB:Q949N0}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, rosette leaves, cauline leaves,
CC shoot apex, stems and flowers. {ECO:0000269|PubMed:17158162}.
CC -!- INDUCTION: By cold, drought stress and methyl methanesulfonate (MMS)
CC treatment. {ECO:0000269|PubMed:17158162}.
CC -!- DOMAIN: The NAC domain includes a DNA binding domain and a dimerization
CC domain. {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF26460.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007323; AAF26460.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE27216.1; -; Genomic_DNA.
DR EMBL; AF439834; AAL27505.1; -; mRNA.
DR EMBL; BT001115; AAN64506.1; -; mRNA.
DR EMBL; AK226863; BAE98952.1; -; mRNA.
DR PIR; A86141; A86141.
DR RefSeq; NP_171609.1; NM_099983.2.
DR AlphaFoldDB; Q0WV96; -.
DR SMR; Q0WV96; -.
DR BioGRID; 24815; 13.
DR IntAct; Q0WV96; 34.
DR STRING; 3702.AT1G01010.1; -.
DR PaxDb; Q0WV96; -.
DR PRIDE; Q0WV96; -.
DR ProteomicsDB; 251089; -.
DR EnsemblPlants; AT1G01010.1; AT1G01010.1; AT1G01010.
DR GeneID; 839580; -.
DR Gramene; AT1G01010.1; AT1G01010.1; AT1G01010.
DR KEGG; ath:AT1G01010; -.
DR Araport; AT1G01010; -.
DR TAIR; locus:2200935; AT1G01010.
DR HOGENOM; CLU_661149_0_0_1; -.
DR InParanoid; Q0WV96; -.
DR OMA; VEVKDQW; -.
DR OrthoDB; 977080at2759; -.
DR PhylomeDB; Q0WV96; -.
DR PRO; PR:Q0WV96; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q0WV96; baseline and differential.
DR Genevisible; Q0WV96; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR Gene3D; 2.170.150.80; -; 1.
DR InterPro; IPR003441; NAC-dom.
DR InterPro; IPR036093; NAC_dom_sf.
DR Pfam; PF02365; NAM; 1.
DR SUPFAM; SSF101941; SSF101941; 1.
DR PROSITE; PS51005; NAC; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Membrane; Nucleus; Reference proteome;
KW Stress response; Transcription; Transcription regulation; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..429
FT /note="NAC domain-containing protein 1"
FT /id="PRO_0000376610"
FT TRANSMEM 408..428
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 10..160
FT /note="NAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT DNA_BIND 110..162
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT REGION 184..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 117
FT /note="V -> A (in Ref. 4; BAE98952)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 429 AA; 49426 MW; 4058A38B6A3D5E29 CRC64;
MEDQVGFGFR PNDEELVGHY LRNKIEGNTS RDVEVAISEV NICSYDPWNL RFQSKYKSRD
AMWYFFSRRE NNKGNRQSRT TVSGKWKLTG ESVEVKDQWG FCSEGFRGKI GHKRVLVFLD
GRYPDKTKSD WVIHEFHYDL LPEHQRTYVI CRLEYKGDDA DILSAYAIDP TPAFVPNMTS
SAGSVVNQSR QRNSGSYNTY SEYDSANHGQ QFNENSNIMQ QQPLQGSFNP LLEYDFANHG
GQWLSDYIDL QQQVPYLAPY ENESEMIWKH VIEENFEFLV DERTSMQQHY SDHRPKKPVS
GVLPDDSSDT ETGSMIFEDT SSSTDSVGSS DEPGHTRIDD IPSLNIIEPL HNYKAQEQPK
QQSKEKVISS QKSECEWKMA EDSIKIPPST NTVKQSWIVL ENAQWNYLKN MIIGVLLFIS
VISWIILVG
