ID   NAC26_ARATH             Reviewed;         394 AA.
AC   F4HYV5; Q9SI80;
DT   27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=NAC domain-containing protein 26 {ECO:0000303|PubMed:15029955};
DE            Short=ANAC026 {ECO:0000303|PubMed:15029955};
DE   AltName: Full=Protein VASCULAR RELATED NAC-DOMAIN 5 {ECO:0000303|PubMed:16103214};
GN   Name=NAC026 {ECO:0000303|PubMed:15029955};
GN   Synonyms=VND5 {ECO:0000303|PubMed:16103214};
GN   OrderedLocusNames=At1g62700 {ECO:0000312|Araport:AT1G62700};
GN   ORFNames=F23N19.6 {ECO:0000312|EMBL:AAF19551.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15029955; DOI=10.1093/dnares/10.6.239;
RA   Ooka H., Satoh K., Doi K., Nagata T., Otomo Y., Murakami K., Matsubara K.,
RA   Osato N., Kawai J., Carninci P., Hayashizaki Y., Suzuki K., Kojima K.,
RA   Takahara Y., Yamamoto K., Kikuchi S.;
RT   "Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis
RT   thaliana.";
RL   DNA Res. 10:239-247(2003).
RN   [4]
RP   DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16103214; DOI=10.1101/gad.1331305;
RA   Kubo M., Udagawa M., Nishikubo N., Horiguchi G., Yamaguchi M., Ito J.,
RA   Mimura T., Fukuda H., Demura T.;
RT   "Transcription switches for protoxylem and metaxylem vessel formation.";
RL   Genes Dev. 19:1855-1860(2005).
RN   [5]
RP   TISSUE SPECIFICITY.
RX   PubMed=17565617; DOI=10.1111/j.1365-313x.2007.03109.x;
RA   Ko J.-H., Yang S.H., Park A.H., Lerouxel O., Han K.-H.;
RT   "ANAC012, a member of the plant-specific NAC transcription factor family,
RT   negatively regulates xylary fiber development in Arabidopsis thaliana.";
RL   Plant J. 50:1035-1048(2007).
RN   [6]
RP   TISSUE SPECIFICITY.
RC   STRAIN=cv. Columbia;
RX   PubMed=18445131; DOI=10.1111/j.1365-313x.2008.03533.x;
RA   Yamaguchi M., Kubo M., Fukuda H., Demura T.;
RT   "Vascular-related NAC-DOMAIN7 is involved in the differentiation of all
RT   types of xylem vessels in Arabidopsis roots and shoots.";
RL   Plant J. 55:652-664(2008).
RN   [7]
RP   INTERACTION WITH NAC083/VNI2.
RX   PubMed=20388856; DOI=10.1105/tpc.108.064048;
RA   Yamaguchi M., Ohtani M., Mitsuda N., Kubo M., Ohme-Takagi M., Fukuda H.,
RA   Demura T.;
RT   "VND-INTERACTING2, a NAC domain transcription factor, negatively regulates
RT   xylem vessel formation in Arabidopsis.";
RL   Plant Cell 22:1249-1263(2010).
RN   [8]
RP   FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=25148240; DOI=10.1371/journal.pone.0105726;
RA   Zhou J., Zhong R., Ye Z.-H.;
RT   "Arabidopsis NAC domain proteins, VND1 to VND5, are transcriptional
RT   regulators of secondary wall biosynthesis in vessels.";
RL   PLoS ONE 9:E105726-E105726(2014).
CC   -!- FUNCTION: Transcription activator that binds to the secondary wall NAC
CC       binding element (SNBE), 5'-
CC       (T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of
CC       target genes (By similarity). Involved in xylem formation by promoting
CC       the expression of secondary wall-associated transcription factors and
CC       of genes involved in secondary wall biosynthesis and programmed cell
CC       death, genes driven by the secondary wall NAC binding element (SNBE).
CC       Triggers thickening of secondary walls (PubMed:25148240).
CC       {ECO:0000250|UniProtKB:Q9LVA1, ECO:0000269|PubMed:25148240}.
CC   -!- SUBUNIT: Interacts with NAC083/VNI2. {ECO:0000269|PubMed:20388856}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9C8W9,
CC       ECO:0000255|PROSITE-ProRule:PRU00353}.
CC   -!- TISSUE SPECIFICITY: Detected in root vessels of protoxylems, outermost
CC       metaxylems, inner metaxylems, shoots and hypocotyls. Expressed in
CC       roots, hypocotyls, cotyledons and leaves (PubMed:18445131). Expressed
CC       in developing xylems (PubMed:16103214, PubMed:17565617). Specifically
CC       expressed in vessels in the secondary xylem of the root-hypocotyl
CC       region, and in vessels but not in interfascicular fibers in stems
CC       (PubMed:25148240). {ECO:0000269|PubMed:16103214,
CC       ECO:0000269|PubMed:17565617, ECO:0000269|PubMed:18445131,
CC       ECO:0000269|PubMed:25148240}.
CC   -!- DEVELOPMENTAL STAGE: Up-regulated during xylem vessel element
CC       formation. Expressed preferentially in procambial cells adjacent to
CC       root meristem. {ECO:0000269|PubMed:16103214,
CC       ECO:0000269|PubMed:25148240}.
CC   -!- DOMAIN: The NAC domain includes a DNA binding domain and a dimerization
CC       domain. {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC   -!- SIMILARITY: Belongs to the plant vascular related NAC-domain protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF19551.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC007190; AAF19551.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE33995.1; -; Genomic_DNA.
DR   EMBL; CP002684; ANM59940.1; -; Genomic_DNA.
DR   RefSeq; NP_001319296.1; NM_001334050.1.
DR   RefSeq; NP_176457.1; NM_104947.2.
DR   AlphaFoldDB; F4HYV5; -.
DR   SMR; F4HYV5; -.
DR   IntAct; F4HYV5; 4.
DR   STRING; 3702.AT1G62700.1; -.
DR   PaxDb; F4HYV5; -.
DR   PRIDE; F4HYV5; -.
DR   ProteomicsDB; 251244; -.
DR   EnsemblPlants; AT1G62700.1; AT1G62700.1; AT1G62700.
DR   EnsemblPlants; AT1G62700.2; AT1G62700.2; AT1G62700.
DR   GeneID; 842568; -.
DR   Gramene; AT1G62700.1; AT1G62700.1; AT1G62700.
DR   Gramene; AT1G62700.2; AT1G62700.2; AT1G62700.
DR   KEGG; ath:AT1G62700; -.
DR   Araport; AT1G62700; -.
DR   TAIR; locus:2026232; AT1G62700.
DR   eggNOG; ENOG502QT6P; Eukaryota.
DR   HOGENOM; CLU_035664_1_2_1; -.
DR   InParanoid; F4HYV5; -.
DR   OMA; DYIMHEY; -.
DR   OrthoDB; 688436at2759; -.
DR   PRO; PR:F4HYV5; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; F4HYV5; baseline and differential.
DR   Genevisible; F4HYV5; AT.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:1901348; P:positive regulation of secondary cell wall biogenesis; IMP:TAIR.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:TAIR.
DR   GO; GO:0048759; P:xylem vessel member cell differentiation; IMP:TAIR.
DR   Gene3D; 2.170.150.80; -; 1.
DR   InterPro; IPR003441; NAC-dom.
DR   InterPro; IPR036093; NAC_dom_sf.
DR   Pfam; PF02365; NAM; 1.
DR   SUPFAM; SSF101941; SSF101941; 1.
DR   PROSITE; PS51005; NAC; 1.
PE   1: Evidence at protein level;
KW   Activator; Cell wall biogenesis/degradation; Developmental protein;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..394
FT                   /note="NAC domain-containing protein 26"
FT                   /id="PRO_0000433119"
FT   DOMAIN          7..156
FT                   /note="NAC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT   DNA_BIND        107..162
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
SQ   SEQUENCE   394 AA;  45585 MW;  6A569B09322BD455 CRC64;
     MNSFSQVPPG FRFHPTDEEL VDYYLRKKVA SKRIEIDIIK DVDLYKIEPC DLQELCKIGN
     EEQSEWYFFS HKDKKYPTGT RTNRATKAGF WKATGRDKAI YIRHSLIGMR KTLVFYKGRA
     PNGQKSDWIM HEYRLETSEN GTPQEEGWVV CRVFKKKLAA TVRKMGDYHS SPSQHWYDDQ
     LSFMASEIIS SSPRQFLPNH HYNRHHHQQT LPCGLNAFNN NNPNLQCKQE LELHYNQMVQ
     HQQQNHHLRE SMFLQLPQLE SPTSNCNSDN NNNTRNISNL QKSSNISHEE QLQQGNQSFS
     SLYYDQGVEQ MTTDWRVLDK FVASQLSNDE EAAAVVSSSS HQNNVKIDTR NTGYHVIDEG
     INLPENDSER VVEMGEEYSN AHAASTSSSC QIDL