NAC42_ARATH
ID NAC42_ARATH Reviewed; 275 AA.
AC Q9SK55; C0SV84;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Transcription factor JUNGBRUNNEN 1;
DE AltName: Full=NAC domain-containing protein 42;
DE Short=ANAC042;
GN Name=JUB1; Synonyms=NAC042; OrderedLocusNames=At2g43000; ORFNames=F23E6.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15029955; DOI=10.1093/dnares/10.6.239;
RA Ooka H., Satoh K., Doi K., Nagata T., Otomo Y., Murakami K., Matsubara K.,
RA Osato N., Kawai J., Carninci P., Hayashizaki Y., Suzuki K., Kojima K.,
RA Takahara Y., Yamamoto K., Kikuchi S.;
RT "Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis
RT thaliana.";
RL DNA Res. 10:239-247(2003).
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, INDUCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DNA-BINDING.
RC STRAIN=cv. Columbia;
RX PubMed=22345491; DOI=10.1105/tpc.111.090894;
RA Wu A., Allu A.D., Garapati P., Siddiqui H., Dortay H., Zanor M.I.,
RA Asensi-Fabado M.A., Munne-Bosch S., Antonio C., Tohge T., Fernie A.R.,
RA Kaufmann K., Xue G.P., Mueller-Roeber B., Balazadeh S.;
RT "JUNGBRUNNEN1, a reactive oxygen species-responsive NAC transcription
RT factor, regulates longevity in Arabidopsis.";
RL Plant Cell 24:482-506(2012).
CC -!- FUNCTION: Transcription factor that binds to the 5'- RRYGCCGT-3'
CC consensus core sequence. Central longevity regulator. Negative
CC regulator of leaf senescence. Modulates cellular H(2)O(2) levels and
CC enhances tolerance to various abiotic stresses through the regulation
CC of DREB2A. {ECO:0000269|PubMed:22345491}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353,
CC ECO:0000269|PubMed:22345491}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, root caps, cotyledons, tips and
CC margin of young leaves, senescent regions of fully expanded leaves and
CC floral tissues, including old sepals, petals, staments, mature anthers
CC and pollen grains. Not detected in the abscission zone of open flowers,
CC emerging lateral roots and root meristematic zones.
CC {ECO:0000269|PubMed:22345491}.
CC -!- INDUCTION: Up-regulated by H(2)O(2), paraquat, ozone, 3-aminotriazole
CC and salt stress. {ECO:0000269|PubMed:22345491}.
CC -!- DOMAIN: The NAC domain includes a DNA-binding domain and a dimerization
CC domain.
CC -!- DISRUPTION PHENOTYPE: Precocious senescence and lowered abiotic stress
CC tolerance. {ECO:0000269|PubMed:22345491}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC006580; AAD22369.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10196.1; -; Genomic_DNA.
DR EMBL; AB493587; BAH30425.1; -; mRNA.
DR PIR; G84860; G84860.
DR RefSeq; NP_181828.1; NM_129861.3.
DR AlphaFoldDB; Q9SK55; -.
DR SMR; Q9SK55; -.
DR BioGRID; 4239; 3.
DR IntAct; Q9SK55; 1.
DR STRING; 3702.AT2G43000.1; -.
DR PaxDb; Q9SK55; -.
DR PRIDE; Q9SK55; -.
DR EnsemblPlants; AT2G43000.1; AT2G43000.1; AT2G43000.
DR GeneID; 818902; -.
DR Gramene; AT2G43000.1; AT2G43000.1; AT2G43000.
DR KEGG; ath:AT2G43000; -.
DR Araport; AT2G43000; -.
DR TAIR; locus:2045570; AT2G43000.
DR eggNOG; ENOG502QUH6; Eukaryota.
DR HOGENOM; CLU_035664_0_0_1; -.
DR InParanoid; Q9SK55; -.
DR OMA; SHRIVEH; -.
DR OrthoDB; 986851at2759; -.
DR PhylomeDB; Q9SK55; -.
DR PRO; PR:Q9SK55; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SK55; baseline and differential.
DR Genevisible; Q9SK55; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0009718; P:anthocyanin-containing compound biosynthetic process; IMP:TAIR.
DR GO; GO:0010120; P:camalexin biosynthetic process; IMP:TAIR.
DR GO; GO:0042538; P:hyperosmotic salinity response; IMP:TAIR.
DR GO; GO:0010150; P:leaf senescence; IMP:TAIR.
DR GO; GO:1900056; P:negative regulation of leaf senescence; IMP:TAIR.
DR GO; GO:0006561; P:proline biosynthetic process; IMP:TAIR.
DR GO; GO:2000377; P:regulation of reactive oxygen species metabolic process; IGI:TAIR.
DR GO; GO:0005992; P:trehalose biosynthetic process; IMP:TAIR.
DR Gene3D; 2.170.150.80; -; 1.
DR InterPro; IPR003441; NAC-dom.
DR InterPro; IPR036093; NAC_dom_sf.
DR Pfam; PF02365; NAM; 1.
DR SUPFAM; SSF101941; SSF101941; 1.
DR PROSITE; PS51005; NAC; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..275
FT /note="Transcription factor JUNGBRUNNEN 1"
FT /id="PRO_0000132312"
FT DOMAIN 18..167
FT /note="NAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT DNA_BIND 115..173
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 275 AA; 31456 MW; B185492D80179F15 CRC64;
MSGEGNLGKD HEEENEAPLP GFRFHPTDEE LLGYYLRRKV ENKTIKLELI KQIDIYKYDP
WDLPRVSSVG EKEWYFFCMR GRKYRNSVRP NRVTGSGFWK ATGIDKPVYS NLDCVGLKKS
LVYYLGSAGK GTKTDWMMHE FRLPSTTKTD SPAQQAEVWT LCRIFKRVTS QRNPTILPPN
RKPVITLTDT CSKTSSLDSD HTSHRTVDSM SHEPPLPQPQ NPYWNQHIVG FNQPTYTGND
NNLLMSFWNG NGGDFIGDSA SWDELRSVID GNTKP
