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NAC46_ARATH
ID   NAC46_ARATH             Reviewed;         338 AA.
AC   Q9SQQ6;
DT   20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=NAC domain-containing protein 46 {ECO:0000303|PubMed:15029955};
DE            Short=ANAC046 {ECO:0000303|PubMed:15029955};
GN   Name=NAC046 {ECO:0000312|EMBL:AEE74032.1};
GN   OrderedLocusNames=At3g04060 {ECO:0000312|Araport:AT3G04060};
GN   ORFNames=T11I18.17 {ECO:0000312|EMBL:AAF05864.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15029955; DOI=10.1093/dnares/10.6.239;
RA   Ooka H., Satoh K., Doi K., Nagata T., Otomo Y., Murakami K., Matsubara K.,
RA   Osato N., Kawai J., Carninci P., Hayashizaki Y., Suzuki K., Kojima K.,
RA   Takahara Y., Yamamoto K., Kikuchi S.;
RT   "Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis
RT   thaliana.";
RL   DNA Res. 10:239-247(2003).
RN   [6]
RP   INTERACTION WITH RCD1.
RX   PubMed=25348421; DOI=10.1042/bj20141045;
RA   O'Shea C., Kryger M., Stender E.G., Kragelund B.B., Willemoes M.,
RA   Skriver K.;
RT   "Protein intrinsic disorder in Arabidopsis NAC transcription factors:
RT   transcriptional activation by ANAC013 and ANAC046 and their interactions
RT   with RCD1.";
RL   Biochem. J. 465:281-294(2015).
RN   [7]
RP   FUNCTION.
RX   PubMed=27021284; DOI=10.1038/srep23609;
RA   Oda-Yamamizo C., Mitsuda N., Sakamoto S., Ogawa D., Ohme-Takagi M.,
RA   Ohmiya A.;
RT   "The NAC transcription factor ANAC046 is a positive regulator of
RT   chlorophyll degradation and senescence in Arabidopsis leaves.";
RL   Sci. Rep. 6:23609-23609(2016).
CC   -!- FUNCTION: Transcriptional activator that acts as positive regulator of
CC       leaf senescence. Activates NYC1, SGR1, SGR2 and PAO, which are genes
CC       involved in chlorophyll catabolic processes. Activates senescence-
CC       associated genes, such as RNS1, SAG12 and SAG13.
CC       {ECO:0000269|PubMed:27021284}.
CC   -!- SUBUNIT: Interacts with RCD1. {ECO:0000269|PubMed:25348421}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC   -!- DOMAIN: The NAC domain includes a DNA binding domain and a dimerization
CC       domain. {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC   -!- MISCELLANEOUS: Plants overexpressing NAC046 exhibit early-senescence
CC       phenotype and reduced chlorophyll content. Plants silencing NAC046
CC       exhibit delayed-senescence phenotype and increased chlorophyll content.
CC       {ECO:0000269|PubMed:27021284}.
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DR   EMBL; AC011698; AAF05864.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE74032.1; -; Genomic_DNA.
DR   EMBL; AF361623; AAK32791.1; -; mRNA.
DR   EMBL; AY081834; AAL87404.1; -; mRNA.
DR   EMBL; AY084852; AAM61417.1; -; mRNA.
DR   RefSeq; NP_187056.1; NM_111277.2.
DR   AlphaFoldDB; Q9SQQ6; -.
DR   SMR; Q9SQQ6; -.
DR   IntAct; Q9SQQ6; 1.
DR   STRING; 3702.AT3G04060.1; -.
DR   PaxDb; Q9SQQ6; -.
DR   PRIDE; Q9SQQ6; -.
DR   DNASU; 819561; -.
DR   EnsemblPlants; AT3G04060.1; AT3G04060.1; AT3G04060.
DR   GeneID; 819561; -.
DR   Gramene; AT3G04060.1; AT3G04060.1; AT3G04060.
DR   KEGG; ath:AT3G04060; -.
DR   Araport; AT3G04060; -.
DR   TAIR; locus:2095958; AT3G04060.
DR   eggNOG; ENOG502QSPY; Eukaryota.
DR   HOGENOM; CLU_035664_6_1_1; -.
DR   InParanoid; Q9SQQ6; -.
DR   OMA; NFPYHSV; -.
DR   OrthoDB; 949787at2759; -.
DR   PhylomeDB; Q9SQQ6; -.
DR   PRO; PR:Q9SQQ6; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9SQQ6; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR   GO; GO:1903648; P:positive regulation of chlorophyll catabolic process; IMP:TAIR.
DR   GO; GO:1900057; P:positive regulation of leaf senescence; IMP:TAIR.
DR   DisProt; DP02225; -.
DR   Gene3D; 2.170.150.80; -; 1.
DR   InterPro; IPR003441; NAC-dom.
DR   InterPro; IPR036093; NAC_dom_sf.
DR   Pfam; PF02365; NAM; 1.
DR   SUPFAM; SSF101941; SSF101941; 1.
DR   PROSITE; PS51005; NAC; 1.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..338
FT                   /note="NAC domain-containing protein 46"
FT                   /id="PRO_0000442492"
FT   DOMAIN          20..171
FT                   /note="NAC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT   DNA_BIND        118..177
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
SQ   SEQUENCE   338 AA;  37781 MW;  0E26D2C0045E2FE1 CRC64;
     MVEEGGVVVN QGGDQEVVDL PPGFRFHPTD EEIITHYLKE KVFNIRFTAA AIGQADLNKN
     EPWDLPKIAK MGEKEFYFFC QRDRKYPTGM RTNRATVSGY WKATGKDKEI FRGKGCLVGM
     KKTLVFYTGR APKGEKTNWV MHEYRLDGKY SYHNLPKTAR DEWVVCRVFH KNAPSTTITT
     TKQLSRIDSL DNIDHLLDFS SLPPLIDPGF LGQPGPSFSG ARQQHDLKPV LHHPTTAPVD
     NTYLPTQALN FPYHSVHNSG SDFGYGAGSG NNNKGMIKLE HSLVSVSQET GLSSDVNTTA
     TPEISSYPMM MNPAMMDGSK SACDGLDDLI FWEDLYTS
 
 
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