NAC48_ORYSJ
ID NAC48_ORYSJ Reviewed; 303 AA.
AC Q7F2L3; A3A0A1; Q0JH48; Q9MBC4;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=NAC domain-containing protein 48 {ECO:0000303|PubMed:15029955};
DE Short=ONAC048 {ECO:0000303|PubMed:15029955};
DE AltName: Full=OsNAC6 {ECO:0000303|PubMed:10660065};
DE AltName: Full=Protein STRESS-RESPONSIVE NAC 2 {ECO:0000303|PubMed:18273684};
GN Name=NAC048 {ECO:0000303|PubMed:15029955};
GN Synonyms=NAC6 {ECO:0000303|PubMed:10660065},
GN SNAC2 {ECO:0000303|PubMed:18273684};
GN OrderedLocusNames=Os01g0884300 {ECO:0000312|EMBL:BAS75586.1},
GN LOC_Os01g66120 {ECO:0000305};
GN ORFNames=B1065E10.51 {ECO:0000312|EMBL:BAB90381.1},
GN OsJ_04317 {ECO:0000312|EMBL:EAZ14398.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=10660065; DOI=10.1007/pl00008647;
RA Kikuchi K., Ueguchi-Tanaka M., Yoshida K.T., Nagato Y., Matsusoka M.,
RA Hirano H.-Y.;
RT "Molecular analysis of the NAC gene family in rice.";
RL Mol. Gen. Genet. 262:1047-1051(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RA Yoon U.-H., Hahn J.-H., Eun M.-Y.;
RT "Molecular cloning of NAC6 gene in rice.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Yoon U.H., Kim Y.H.;
RT "Molecular cloning of NAC6 gene in rice.";
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447438; DOI=10.1038/nature01184;
RA Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT "The genome sequence and structure of rice chromosome 1.";
RL Nature 420:312-316(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [6]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [7]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [10]
RP INDUCTION.
RX PubMed=11332734; DOI=10.1094/mpmi.2001.14.5.685;
RA Xiong L., Lee M.W., Qi M., Yang Y.;
RT "Identification of defense-related rice genes by suppression subtractive
RT hybridization and differential screening.";
RL Mol. Plant Microbe Interact. 14:685-692(2001).
RN [11]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15029955; DOI=10.1093/dnares/10.6.239;
RA Ooka H., Satoh K., Doi K., Nagata T., Otomo Y., Murakami K., Matsubara K.,
RA Osato N., Kawai J., Carninci P., Hayashizaki Y., Suzuki K., Kojima K.,
RA Takahara Y., Yamamoto K., Kikuchi S.;
RT "Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis
RT thaliana.";
RL DNA Res. 10:239-247(2003).
RN [12]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=17587305; DOI=10.1111/j.1365-313x.2007.03168.x;
RA Nakashima K., Tran L.S., Van Nguyen D., Fujita M., Maruyama K., Todaka D.,
RA Ito Y., Hayashi N., Shinozaki K., Yamaguchi-Shinozaki K.;
RT "Functional analysis of a NAC-type transcription factor OsNAC6 involved in
RT abiotic and biotic stress-responsive gene expression in rice.";
RL Plant J. 51:617-630(2007).
RN [13]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=18273684; DOI=10.1007/s11103-008-9309-5;
RA Hu H., You J., Fang Y., Zhu X., Qi Z., Xiong L.;
RT "Characterization of transcription factor gene SNAC2 conferring cold and
RT salt tolerance in rice.";
RL Plant Mol. Biol. 67:169-181(2008).
RN [14]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=19453457; DOI=10.1111/j.1365-313x.2009.03908.x;
RA Chung P.J., Kim Y.S., Jeong J.S., Park S.H., Nahm B.H., Kim J.K.;
RT "The histone deacetylase OsHDAC1 epigenetically regulates the OsNAC6 gene
RT that controls seedling root growth in rice.";
RL Plant J. 59:764-776(2009).
RN [15]
RP FUNCTION, INTERACTION WITH NAC071, SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=20632034; DOI=10.1007/s00438-010-0557-0;
RA Takasaki H., Maruyama K., Kidokoro S., Ito Y., Fujita Y., Shinozaki K.,
RA Yamaguchi-Shinozaki K., Nakashima K.;
RT "The abiotic stress-responsive NAC-type transcription factor OsNAC5
RT regulates stress-inducible genes and stress tolerance in rice.";
RL Mol. Genet. Genomics 284:173-183(2010).
RN [16]
RP FUNCTION, AND INDUCTION.
RX PubMed=27892643; DOI=10.1111/pbi.12673;
RA Lee D.K., Chung P.J., Jeong J.S., Jang G., Bang S.W., Jung H., Kim Y.S.,
RA Ha S.H., Choi Y.D., Kim J.K.;
RT "The rice OsNAC6 transcription factor orchestrates multiple molecular
RT mechanisms involving root structural adaptions and nicotianamine
RT biosynthesis for drought tolerance.";
RL Plant Biotechnol. J. 15:754-764(2017).
CC -!- FUNCTION: Transcription activator that binds to the promoter of the
CC stress response gene LEA19. Involved in tolerance to abiotic stresses
CC (PubMed:20632034). Transcription activator involved in response to
CC abiotic and biotic stresses. Involved in drought and salt stress
CC responses, and defense response to the rice blast fungus
CC (PubMed:17587305). Transcription activator involved tolerance to cold
CC and salt stresses (PubMed:18273684). Transcription activator involved
CC in tolerance to drought stress. Targets directly and activates genes
CC involved in membrane modification, nicotianamine (NA) biosynthesis,
CC glutathione relocation, accumulation of phosphoadenosine phosphosulfate
CC and glycosylation in roots (PubMed:27892643). Controls root growth at
CC early vegetative stage through chromatin modification and histone
CC lysine deacytaltion by HDAC1 (PubMed:19453457).
CC {ECO:0000269|PubMed:17587305, ECO:0000269|PubMed:18273684,
CC ECO:0000269|PubMed:19453457, ECO:0000269|PubMed:20632034,
CC ECO:0000269|PubMed:27892643}.
CC -!- SUBUNIT: Interacts with NAC071. {ECO:0000269|PubMed:20632034}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353,
CC ECO:0000269|PubMed:17587305, ECO:0000269|PubMed:18273684,
CC ECO:0000269|PubMed:20632034}.
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:10660065}.
CC -!- INDUCTION: Induced by drought stress, salt stress, cold stress and
CC abscisic acid (ABA) (PubMed:20632034, PubMed:27892643). Induced by
CC methyl jasmonate (PubMed:20632034, PubMed:11332734). Induced by
CC infection with the rice blast fungus Magnaporthe oryzae
CC (PubMed:11332734). {ECO:0000269|PubMed:11332734,
CC ECO:0000269|PubMed:20632034, ECO:0000269|PubMed:27892643}.
CC -!- DOMAIN: The NAC domain includes a DNA binding domain and a dimerization
CC domain. {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC -!- DISRUPTION PHENOTYPE: Increased root length in young seedlings.
CC {ECO:0000269|PubMed:19453457}.
CC -!- MISCELLANEOUS: Plants overexpressing NAC048 exhibit growth retardation
CC (PubMed:17587305, PubMed:20632034). Plants overexpressing NAC048
CC exhibit improved tolerance to drought stress (PubMed:17587305,
CC PubMed:27892643). Plants overexpressing NAC048 show increased tolerance
CC to salt stress (PubMed:17587305, PubMed:18273684). Plants
CC overexpressing NAC048 exhibit increased tolerance to cold stress
CC (PubMed:18273684). Plants overexpressing NAC048 show increased
CC resistance to rice blast fungus (PubMed:17587305).
CC {ECO:0000269|PubMed:17587305, ECO:0000269|PubMed:18273684,
CC ECO:0000269|PubMed:20632034, ECO:0000269|PubMed:27892643}.
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DR EMBL; AB028185; BAA89800.1; -; mRNA.
DR EMBL; AF254558; AAK17067.1; -; Genomic_DNA.
DR EMBL; EU846993; ACJ54897.1; -; mRNA.
DR EMBL; AP003561; BAB90381.1; -; Genomic_DNA.
DR EMBL; AP008207; BAF06930.1; -; Genomic_DNA.
DR EMBL; AP014957; BAS75586.1; -; Genomic_DNA.
DR EMBL; CM000138; EAZ14398.1; -; Genomic_DNA.
DR EMBL; AK068392; BAG90892.1; -; mRNA.
DR PIR; T52345; T52345.
DR RefSeq; XP_015620920.1; XM_015765434.1.
DR AlphaFoldDB; Q7F2L3; -.
DR SMR; Q7F2L3; -.
DR STRING; 4530.OS01T0884300-01; -.
DR PaxDb; Q7F2L3; -.
DR PRIDE; Q7F2L3; -.
DR EnsemblPlants; Os01t0884300-01; Os01t0884300-01; Os01g0884300.
DR GeneID; 4325006; -.
DR Gramene; Os01t0884300-01; Os01t0884300-01; Os01g0884300.
DR KEGG; osa:4325006; -.
DR eggNOG; ENOG502QVRF; Eukaryota.
DR HOGENOM; CLU_035664_3_1_1; -.
DR InParanoid; Q7F2L3; -.
DR OMA; GVERKPM; -.
DR OrthoDB; 977765at2759; -.
DR Proteomes; UP000000763; Chromosome 1.
DR Proteomes; UP000007752; Chromosome 1.
DR Proteomes; UP000059680; Chromosome 1.
DR Genevisible; Q7F2L3; OS.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:1901002; P:positive regulation of response to salt stress; IMP:UniProtKB.
DR GO; GO:1902584; P:positive regulation of response to water deprivation; IMP:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:1900150; P:regulation of defense response to fungus; IMP:UniProtKB.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR GO; GO:0009409; P:response to cold; IMP:UniProtKB.
DR GO; GO:0048364; P:root development; IMP:UniProtKB.
DR Gene3D; 2.170.150.80; -; 1.
DR InterPro; IPR003441; NAC-dom.
DR InterPro; IPR036093; NAC_dom_sf.
DR Pfam; PF02365; NAM; 1.
DR SUPFAM; SSF101941; SSF101941; 1.
DR PROSITE; PS51005; NAC; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Growth regulation; Nucleus; Reference proteome;
KW Stress response; Transcription; Transcription regulation.
FT CHAIN 1..303
FT /note="NAC domain-containing protein 48"
FT /id="PRO_0000132317"
FT DOMAIN 9..159
FT /note="NAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT CONFLICT 288
FT /note="S -> R (in Ref. 8; EAZ14398)"
FT /evidence="ECO:0000305"
FT CONFLICT 294
FT /note="D -> E (in Ref. 8; EAZ14398)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 303 AA; 32907 MW; E9E1ACBE29D54D1E CRC64;
MSGGQDLQLP PGFRFHPTDE ELVMHYLCRR CAGLPIAVPI IAEIDLYKFD PWQLPRMALY
GEKEWYFFSP RDRKYPNGSR PNRAAGSGYW KATGADKPVG SPKPVAIKKA LVFYAGKAPK
GEKTNWIMHE YRLADVDRSA RKKNSLRLDD WVLCRIYNKK GGLEKPPAAA VAAAGMVSSG
GGVQRKPMVG VNAAVSSPPE QKPVVAGPAF PDLAAYYDRP SDSMPRLHAD SSCSEQVLSP
EFACEVQSQP KISEWERTFA TVGPINPAAS ILDPAGSGGL GGLGGGGSDP LLQDILMYWG
KPF
