NAC59_ARATH
ID NAC59_ARATH Reviewed; 318 AA.
AC Q9LJW3;
DT 22-JUL-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=NAC domain-containing protein 59 {ECO:0000303|PubMed:15029955};
DE Short=ANAC059 {ECO:0000303|PubMed:15029955};
DE Short=AtNAC3 {ECO:0000303|PubMed:16359384};
DE AltName: Full=Protein ORE1 SISTER1 {ECO:0000303|PubMed:21303842};
GN Name=NAC59 {ECO:0000303|PubMed:15029955};
GN Synonyms=NAC3 {ECO:0000303|PubMed:16359384},
GN ORS1 {ECO:0000303|PubMed:21303842};
GN OrderedLocusNames=At3g29035 {ECO:0000312|Araport:AT3G29035};
GN ORFNames=MRI12.1 {ECO:0000312|EMBL:AAL32716.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15029955; DOI=10.1093/dnares/10.6.239;
RA Ooka H., Satoh K., Doi K., Nagata T., Otomo Y., Murakami K., Matsubara K.,
RA Osato N., Kawai J., Carninci P., Hayashizaki Y., Suzuki K., Kojima K.,
RA Takahara Y., Yamamoto K., Kikuchi S.;
RT "Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis
RT thaliana.";
RL DNA Res. 10:239-247(2003).
RN [6]
RP FUNCTION.
RX PubMed=16359384; DOI=10.1111/j.1365-313x.2005.02575.x;
RA He X.-J., Mu R.-L., Cao W.-H., Zhang Z.-G., Zhang J.-S., Chen S.-Y.;
RT "AtNAC2, a transcription factor downstream of ethylene and auxin signaling
RT pathways, is involved in salt stress response and lateral root
RT development.";
RL Plant J. 44:903-916(2005).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=16581911; DOI=10.1073/pnas.0510607103;
RA Lee J.-Y., Colinas J., Wang J.Y., Mace D., Ohler U., Benfey P.N.;
RT "Transcriptional and posttranscriptional regulation of transcription factor
RT expression in Arabidopsis roots.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:6055-6060(2006).
RN [8]
RP FUNCTION, DISRUPTION PHENOTYPE, INDUCTION BY WOUNDING; H2O2 AND SENESCENCE,
RP DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, AND DNA-BINDING.
RC STRAIN=cv. Columbia;
RX PubMed=21303842; DOI=10.1093/mp/ssq080;
RA Balazadeh S., Kwasniewski M., Caldana C., Mehrnia M., Zanor M.I.,
RA Xue G.-P., Mueller-Roeber B.;
RT "ORS1, an H(2)O(2)-responsive NAC transcription factor, controls senescence
RT in Arabidopsis thaliana.";
RL Mol. Plant 4:346-360(2011).
CC -!- FUNCTION: Transcription activator that binds to DNA in promoters of
CC target genes on a specific bipartite motif 5'-[AG]CGT[AG](4-
CC 5n)[AG][CT]ACGCAA-3' (PubMed:16359384, PubMed:21303842). Triggers the
CC expression of senescence-associated genes during age-, salt- and dark-
CC induced senescence through a regulatory network that may involve cross-
CC talk with salt- and H(2)O(2)-dependent signaling pathways
CC (PubMed:21303842). {ECO:0000269|PubMed:16359384,
CC ECO:0000269|PubMed:21303842}.
CC -!- INTERACTION:
CC Q9LJW3; A0A178UQH2: At5g50820; NbExp=3; IntAct=EBI-4431790, EBI-15191527;
CC Q9LJW3; Q9LXU1: PIM1; NbExp=3; IntAct=EBI-4431790, EBI-15193025;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9FKA0,
CC ECO:0000255|PROSITE-ProRule:PRU00353}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in root cortex, phloem,
CC atrichoblast and quiescent center (QC), and, to a lower extent, in root
CC endodermis, xylem, pericycle, columella and lateral root cap (LRC)
CC (PubMed:16581911). Expressed in roots, cotyledons, very young leaves,
CC senescing leaves, mature flowers and pollen (PubMed:21303842).
CC {ECO:0000269|PubMed:16581911, ECO:0000269|PubMed:21303842}.
CC -!- DEVELOPMENTAL STAGE: Age-dependent accumulation. First observed in
CC young seedlings in cotyledons and regularly in the tip regions of very
CC young leaves. Accumulates strongly in older leaf parts at the
CC senescence onset. In flowers, present in mature organs such as old
CC sepals, petals, old stamens, mature anthers, and pollen grains.
CC Confined to floral organ abscission zone of mature flowers. Also
CC observed in roots. {ECO:0000269|PubMed:21303842}.
CC -!- INDUCTION: Rapidly and strongly induced by H(2)O(2) treatment in both
CC leaves and roots. Accumulates during senescence and in response to
CC wounding. {ECO:0000269|PubMed:21303842}.
CC -!- DOMAIN: The NAC domain includes a DNA binding domain and a dimerization
CC domain. {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC -!- DISRUPTION PHENOTYPE: Delayed senescence accompanied by a small delay
CC in flowering time. {ECO:0000269|PubMed:21303842}.
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DR EMBL; AP000388; BAB02945.1; -; Genomic_DNA.
DR EMBL; AB025615; BAB02945.1; JOINED; Genomic_DNA.
DR EMBL; CP002686; AEE77527.1; -; Genomic_DNA.
DR EMBL; AY062638; AAL32716.1; -; mRNA.
DR EMBL; BT008716; AAP42729.1; -; mRNA.
DR RefSeq; NP_189546.1; NM_113825.4.
DR AlphaFoldDB; Q9LJW3; -.
DR SMR; Q9LJW3; -.
DR IntAct; Q9LJW3; 13.
DR STRING; 3702.AT3G29035.1; -.
DR PaxDb; Q9LJW3; -.
DR PRIDE; Q9LJW3; -.
DR ProteomicsDB; 251226; -.
DR DNASU; 822547; -.
DR EnsemblPlants; AT3G29035.1; AT3G29035.1; AT3G29035.
DR GeneID; 822547; -.
DR Gramene; AT3G29035.1; AT3G29035.1; AT3G29035.
DR KEGG; ath:AT3G29035; -.
DR Araport; AT3G29035; -.
DR TAIR; locus:2087037; AT3G29035.
DR eggNOG; ENOG502QR2M; Eukaryota.
DR HOGENOM; CLU_035664_5_2_1; -.
DR InParanoid; Q9LJW3; -.
DR OMA; ITHYLRP; -.
DR OrthoDB; 1072945at2759; -.
DR PhylomeDB; Q9LJW3; -.
DR PRO; PR:Q9LJW3; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LJW3; baseline and differential.
DR Genevisible; Q9LJW3; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0010150; P:leaf senescence; IMP:TAIR.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:1900057; P:positive regulation of leaf senescence; IMP:UniProtKB.
DR GO; GO:0042542; P:response to hydrogen peroxide; IDA:UniProtKB.
DR GO; GO:0009611; P:response to wounding; IEP:UniProtKB.
DR Gene3D; 2.170.150.80; -; 1.
DR InterPro; IPR003441; NAC-dom.
DR InterPro; IPR036093; NAC_dom_sf.
DR Pfam; PF02365; NAM; 1.
DR SUPFAM; SSF101941; SSF101941; 1.
DR PROSITE; PS51005; NAC; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..318
FT /note="NAC domain-containing protein 59"
FT /id="PRO_0000433471"
FT DOMAIN 24..174
FT /note="NAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT DNA_BIND 121..180
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
SQ SEQUENCE 318 AA; 35826 MW; 67EE3A1DE4F33C93 CRC64;
MDYKVSRSGE IVEGEVEDSE KIDLPPGFRF HPTDEELITH YLRPKVVNSF FSAIAIGEVD
LNKVEPWDLP WKAKLGEKEW YFFCVRDRKY PTGLRTNRAT KAGYWKATGK DKEIFKGKSL
VGMKKTLVFY KGRAPKGVKT NWVMHEYRLE GKFAIDNLSK TAKNECVISR VFHTRTDGTK
EHMSVGLPPL MDSSPYLKSR GQDSLAGTTL GGLLSHVTYF SDQTTDDKSL VADFKTTMFG
SGSTNFLPNI GSLLDFDPLF LQNNSSVLKM LLDNEETQFK KNLHNSGSSE SELTASSWQG
HNSYGSTGPV NLDCVWKF
