NAC73_ARATH
ID NAC73_ARATH Reviewed; 305 AA.
AC O49459;
DT 01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=NAC domain-containing protein 73 {ECO:0000303|PubMed:15029955};
DE Short=ANAC073 {ECO:0000303|PubMed:15029955};
DE AltName: Full=Protein SECONDARY WALL-ASSOCIATED NAC DOMAIN PROTEIN 2 {ECO:0000303|PubMed:18952777};
GN Name=NAC073 {ECO:0000312|EMBL:AEE85495.1};
GN Synonyms=SND2 {ECO:0000303|PubMed:18952777};
GN OrderedLocusNames=At4g28500 {ECO:0000312|Araport:AT4G28500};
GN ORFNames=F20O9.190 {ECO:0000312|EMBL:CAA16890.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15029955; DOI=10.1093/dnares/10.6.239;
RA Ooka H., Satoh K., Doi K., Nagata T., Otomo Y., Murakami K., Matsubara K.,
RA Osato N., Kawai J., Carninci P., Hayashizaki Y., Suzuki K., Kojima K.,
RA Takahara Y., Yamamoto K., Kikuchi S.;
RT "Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis
RT thaliana.";
RL DNA Res. 10:239-247(2003).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=18952777; DOI=10.1105/tpc.108.061325;
RA Zhong R., Lee C., Zhou J., McCarthy R.L., Ye Z.H.;
RT "A battery of transcription factors involved in the regulation of secondary
RT cell wall biosynthesis in Arabidopsis.";
RL Plant Cell 20:2763-2782(2008).
RN [6]
RP FUNCTION.
RX PubMed=22133261; DOI=10.1186/1471-2229-11-173;
RA Hussey S.G., Mizrachi E., Spokevicius A.V., Bossinger G., Berger D.K.,
RA Myburg A.A.;
RT "SND2, a NAC transcription factor gene, regulates genes involved in
RT secondary cell wall development in Arabidopsis fibres and increases fibre
RT cell area in Eucalyptus.";
RL BMC Plant Biol. 11:173-173(2011).
CC -!- FUNCTION: Transcriptional activator that plays a regulatory role in the
CC development of secondary cell wall fibers
CC (PubMed:18952777,PubMed:22133261). Involved in the regulation of
CC cellulose and hemicellulose biosynthetic genes as well as of genes
CC involved in lignin polymerization and signaling (PubMed:22133261). Is
CC not a direct target of SND1 (PubMed:18952777).
CC {ECO:0000269|PubMed:18952777, ECO:0000269|PubMed:22133261}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353,
CC ECO:0000269|PubMed:18952777}.
CC -!- TISSUE SPECIFICITY: Expressed in protoxylem and elongating
CC interfascicular fiber cells of elongating internodes, developing
CC metaxylem cells and interfascicular fibers of non-elongating internodes
CC and developing secondary xylem of roots. {ECO:0000269|PubMed:18952777}.
CC -!- DOMAIN: The NAC domain includes a DNA binding domain and a dimerization
CC domain. {ECO:0000255|PROSITE-ProRule:PRU00353}.
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DR EMBL; AL021749; CAA16890.1; -; Genomic_DNA.
DR EMBL; AL161572; CAB79652.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85495.1; -; Genomic_DNA.
DR EMBL; DQ056658; AAY78805.1; -; mRNA.
DR PIR; T04621; T04621.
DR RefSeq; NP_194579.1; NM_118992.3.
DR AlphaFoldDB; O49459; -.
DR SMR; O49459; -.
DR IntAct; O49459; 2.
DR STRING; 3702.AT4G28500.1; -.
DR PaxDb; O49459; -.
DR PRIDE; O49459; -.
DR ProteomicsDB; 248929; -.
DR EnsemblPlants; AT4G28500.1; AT4G28500.1; AT4G28500.
DR GeneID; 828968; -.
DR Gramene; AT4G28500.1; AT4G28500.1; AT4G28500.
DR KEGG; ath:AT4G28500; -.
DR Araport; AT4G28500; -.
DR TAIR; locus:2121387; AT4G28500.
DR eggNOG; ENOG502QR2Y; Eukaryota.
DR HOGENOM; CLU_025101_1_0_1; -.
DR InParanoid; O49459; -.
DR OMA; EALQDWP; -.
DR OrthoDB; 969155at2759; -.
DR PhylomeDB; O49459; -.
DR PRO; PR:O49459; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O49459; baseline and differential.
DR Genevisible; O49459; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:TAIR.
DR GO; GO:2000652; P:regulation of secondary cell wall biogenesis; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 2.170.150.80; -; 1.
DR InterPro; IPR003441; NAC-dom.
DR InterPro; IPR036093; NAC_dom_sf.
DR InterPro; IPR044799; SOG1-like.
DR PANTHER; PTHR31079; PTHR31079; 1.
DR Pfam; PF02365; NAM; 1.
DR SUPFAM; SSF101941; SSF101941; 1.
DR PROSITE; PS51005; NAC; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..305
FT /note="NAC domain-containing protein 73"
FT /id="PRO_0000432422"
FT DOMAIN 59..219
FT /note="NAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT DNA_BIND 170..225
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
SQ SEQUENCE 305 AA; 33697 MW; C46640A70E714E1B CRC64;
MTWCNDRSDV QTVERIIPSP GAAESPVASL PVSCHKTCPS CGHNFKFHEQ AGIHDLPGLP
AGVKFDPTDQ EVLEHLEGKV RDDAKKLHPL IDEFIRTIDG ENGICYTHPE KLPGVNKDGT
VRHFFHRPSK AYTTGTRKRR KVHTDSDVGG ETRWHKTGKT RPVLAGGRVR GYKKILVLYT
NYGKQKKPEK TNWVMHQYHL GTSEEEKEGE LVVSKVFYQT QPRQCGGSVA AAATAKDRPY
LHGLGGGGGR HLHYHLHHNN GNGKSNGSGG TAGAGEYYHN IPAIISFNQT GIQNHLVHDS
QPFIP
