NAC74_ORYSJ
ID NAC74_ORYSJ Reviewed; 489 AA.
AC Q7GCL7; Q0JNW6; Q9LDX0;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=NAC domain-containing protein 74 {ECO:0000303|PubMed:15029955};
DE Short=ONAC074 {ECO:0000303|PubMed:15029955};
DE AltName: Full=OsNAC8 {ECO:0000303|PubMed:10660065};
DE AltName: Full=Protein NTM1-like 3 {ECO:0000303|PubMed:17158162};
DE Short=OsNTL3 {ECO:0000303|PubMed:17158162};
GN Name=NAC074 {ECO:0000303|PubMed:15029955};
GN Synonyms=NAC8 {ECO:0000303|PubMed:10660065},
GN NTL3 {ECO:0000303|PubMed:17158162};
GN OrderedLocusNames=Os01g0261200 {ECO:0000312|EMBL:BAS71425.1},
GN LOC_Os01g15640 {ECO:0000305};
GN ORFNames=OsJ_01182 {ECO:0000312|EMBL:EEE54276.1},
GN P0469E09.5 {ECO:0000312|EMBL:BAA92400.1},
GN P0699D11.24 {ECO:0000312|EMBL:BAB03447.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=10660065; DOI=10.1007/pl00008647;
RA Kikuchi K., Ueguchi-Tanaka M., Yoshida K.T., Nagato Y., Matsusoka M.,
RA Hirano H.-Y.;
RT "Molecular analysis of the NAC gene family in rice.";
RL Mol. Gen. Genet. 262:1047-1051(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Seed;
RA Yoon U.H., Kim Y.H.;
RT "Structural analysis of expressed sequence tags in immature seed of Oryza
RT sativa L.";
RL Sigmul Saengmyeong Gong Haghoeji 36:130-136(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447438; DOI=10.1038/nature01184;
RA Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT "The genome sequence and structure of rice chromosome 1.";
RL Nature 420:312-316(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [8]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15029955; DOI=10.1093/dnares/10.6.239;
RA Ooka H., Satoh K., Doi K., Nagata T., Otomo Y., Murakami K., Matsubara K.,
RA Osato N., Kawai J., Carninci P., Hayashizaki Y., Suzuki K., Kojima K.,
RA Takahara Y., Yamamoto K., Kikuchi S.;
RT "Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis
RT thaliana.";
RL DNA Res. 10:239-247(2003).
RN [9]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17158162; DOI=10.1093/nar/gkl1068;
RA Kim S.Y., Kim S.G., Kim Y.S., Seo P.J., Bae M., Yoon H.K., Park C.M.;
RT "Exploring membrane-associated NAC transcription factors in Arabidopsis:
RT implications for membrane biology in genome regulation.";
RL Nucleic Acids Res. 35:203-213(2007).
RN [10]
RP INDUCTION.
RX PubMed=18813954; DOI=10.1007/s00438-008-0386-6;
RA Fang Y., You J., Xie K., Xie W., Xiong L.;
RT "Systematic sequence analysis and identification of tissue-specific or
RT stress-responsive genes of NAC transcription factor family in rice.";
RL Mol. Genet. Genomics 280:547-563(2008).
RN [11]
RP FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=31733092; DOI=10.1111/pbi.13297;
RA Liu X.H., Lyu Y.S., Yang W., Yang Z.T., Lu S.J., Liu J.X.;
RT "A membrane-associated NAC transcription factor OsNTL3 is involved in
RT thermotolerance in rice.";
RL Plant Biotechnol. J. 18:1317-1329(2020).
CC -!- FUNCTION: Transcription activator involved in heat and endoplasmic
CC reticulum (ER) stress responses (PubMed:31733092). Regulates the
CC expression of genes involved in ER protein folding and heat stress-
CC responsive genes (PubMed:31733092). Binds directly to the promoter of
CC BZIP74 and regulates its expression in response to heat stress
CC (PubMed:31733092). {ECO:0000269|PubMed:31733092}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353,
CC ECO:0000269|PubMed:31733092}. Cell membrane
CC {ECO:0000269|PubMed:31733092}; Single-pass membrane protein
CC {ECO:0000255}. Note=NTL3 relocates from plasma membrane to nucleus in
CC response to heat and endoplasmic reticulum (ER) stresses.
CC {ECO:0000269|PubMed:31733092}.
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:10660065}.
CC -!- INDUCTION: Induced by salt stress (PubMed:18813954, PubMed:31733092).
CC Induced by cold stress (PubMed:18813954). Induced by
CC dithiothreitol- and tunicamycin-induced endoplasmic reticulum (ER)
CC stress response (PubMed:31733092). Induced by heat shock
CC (PubMed:31733092). {ECO:0000269|PubMed:18813954,
CC ECO:0000269|PubMed:31733092}.
CC -!- DOMAIN: The NAC domain includes a DNA binding domain and a dimerization
CC domain. {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but mutant plants exhibit hypersensitivity to heat stress.
CC {ECO:0000269|PubMed:31733092}.
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DR EMBL; AB028187; BAA89802.1; -; mRNA.
DR EMBL; GU120347; ADR66981.1; -; mRNA.
DR EMBL; AP001366; BAA92400.1; -; Genomic_DNA.
DR EMBL; AP002817; BAB03447.1; -; Genomic_DNA.
DR EMBL; AP008207; BAF04562.1; -; Genomic_DNA.
DR EMBL; AP014957; BAS71425.1; -; Genomic_DNA.
DR EMBL; CM000138; EEE54276.1; -; Genomic_DNA.
DR EMBL; AK102808; BAG95726.1; -; mRNA.
DR RefSeq; XP_015649784.1; XM_015794298.1.
DR AlphaFoldDB; Q7GCL7; -.
DR SMR; Q7GCL7; -.
DR STRING; 4530.OS01T0261200-01; -.
DR PaxDb; Q7GCL7; -.
DR PRIDE; Q7GCL7; -.
DR EnsemblPlants; Os01t0261200-01; Os01t0261200-01; Os01g0261200.
DR GeneID; 4325120; -.
DR Gramene; Os01t0261200-01; Os01t0261200-01; Os01g0261200.
DR KEGG; osa:4325120; -.
DR eggNOG; ENOG502QYZR; Eukaryota.
DR HOGENOM; CLU_038104_0_0_1; -.
DR InParanoid; Q7GCL7; -.
DR OMA; YIDEREC; -.
DR OrthoDB; 697995at2759; -.
DR Proteomes; UP000000763; Chromosome 1.
DR Proteomes; UP000007752; Chromosome 1.
DR Proteomes; UP000059680; Chromosome 1.
DR ExpressionAtlas; Q7GCL7; baseline and differential.
DR Genevisible; Q7GCL7; OS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
DR Gene3D; 2.170.150.80; -; 1.
DR InterPro; IPR003441; NAC-dom.
DR InterPro; IPR036093; NAC_dom_sf.
DR Pfam; PF02365; NAM; 1.
DR SUPFAM; SSF101941; SSF101941; 1.
DR PROSITE; PS51005; NAC; 1.
PE 2: Evidence at transcript level;
KW Activator; Cell membrane; DNA-binding; Membrane; Nucleus;
KW Reference proteome; Stress response; Transcription;
KW Transcription regulation; Transmembrane; Transmembrane helix;
KW Unfolded protein response.
FT CHAIN 1..489
FT /note="NAC domain-containing protein 74"
FT /id="PRO_0000132321"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 9..159
FT /note="NAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT DNA_BIND 108..165
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT REGION 413..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 489 AA; 54694 MW; 45D44A3771B6E25F CRC64;
MESLRDMVLP PGFGFHPKDT ELISHYLKKK IHGQKIEYEI IPEVDIYKHE PWDLPAKCDV
PTQDNKWHFF AARDRKYPNG SRSNRATVAG YWKSTGKDRA IKMGKQTIGT KKTLVFHEGR
PPTGRRTEWI MHEYYIDERE CQACPDMKDA YVLCRITKRN DWIPGNGNEL DNSDPHPEPY
DAPPSVISTE QLNPAAEPVV GVEAAPVTVA EPDGVTTSAI TANIPSPSDD INLDDWLNEL
FDPFFDPEQS LASADLSPDE QNVESSNVGA LAPKVEQDYS SPNENVVDDT EYLLPEDVYN
ILHPGTDDFN MLQNPLDQYP IQYATDVWSG IQKEELWSPQ ANAEPSQSNE AADNGIIRRY
RSMKTPETSV PQFKGKTQAK MRVGINKMAT SSSESINQTI KFENSGRLVE HQKNQAHDVA
STKRSDAGKP STELSSNRGF LRGIRNAFAG CSDARWNMIL VAGFAIGVAV VALHIGQRLG
LSQRDQQHT
