NAC75_ARATH
ID NAC75_ARATH Reviewed; 498 AA.
AC Q9M0F8;
DT 22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=NAC domain-containing protein 75 {ECO:0000303|PubMed:15029955};
DE Short=ANAC075 {ECO:0000303|PubMed:15029955};
GN Name=NAC075 {ECO:0000303|PubMed:15029955};
GN OrderedLocusNames=At4g29230 {ECO:0000312|Araport:AT4G29230};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15029955; DOI=10.1093/dnares/10.6.239;
RA Ooka H., Satoh K., Doi K., Nagata T., Otomo Y., Murakami K., Matsubara K.,
RA Osato N., Kawai J., Carninci P., Hayashizaki Y., Suzuki K., Kojima K.,
RA Takahara Y., Yamamoto K., Kikuchi S.;
RT "Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis
RT thaliana.";
RL DNA Res. 10:239-247(2003).
RN [4]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=25265867; DOI=10.1093/pcp/pcu134;
RA Endo H., Yamaguchi M., Tamura T., Nakano Y., Nishikubo N., Yoneda A.,
RA Kato K., Kubo M., Kajita S., Katayama Y., Ohtani M., Demura T.;
RT "Multiple classes of transcription factors regulate the expression of
RT VASCULAR-RELATED NAC-DOMAIN7, a master switch of xylem vessel
RT differentiation.";
RL Plant Cell Physiol. 56:242-254(2015).
RN [5]
RP FUNCTION.
RX PubMed=25535195; DOI=10.1093/pcp/pcu208;
RA Sakamoto S., Mitsuda N.;
RT "Reconstitution of a secondary cell wall in a secondary cell wall-deficient
RT Arabidopsis mutant.";
RL Plant Cell Physiol. 56:299-310(2015).
CC -!- FUNCTION: Transcription activator involved in xylem formation
CC (PubMed:25265867, PubMed:25535195). Promotes the expression of the
CC secondary wall-associated transcription factor MYB46 (PubMed:25265867).
CC Functions upstream of NAC030/VND7, a master switch of xylem vessel
CC differentiation (PubMed:25265867, PubMed:25535195). Acts as upstream
CC regulator of NAC101/VND6 and LBD30/ASL19 (PubMed:25535195).
CC {ECO:0000269|PubMed:25265867, ECO:0000269|PubMed:25535195}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC -!- TISSUE SPECIFICITY: Expressed in the vascular cylinder of roots.
CC Expressed in the differentiation zone of the root stele.
CC {ECO:0000269|PubMed:25265867}.
CC -!- DOMAIN: The NAC domain includes a DNA binding domain and a dimerization
CC domain. {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC -!- MISCELLANEOUS: Overexpression of NAC075 induces the formation of
CC ectopic xylem vessel-like elements. {ECO:0000269|PubMed:25265867,
CC ECO:0000269|PubMed:25535195}.
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DR EMBL; AL161574; CAB79681.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85605.1; -; Genomic_DNA.
DR PIR; T13434; T13434.
DR RefSeq; NP_194652.1; NM_119067.2.
DR AlphaFoldDB; Q9M0F8; -.
DR SMR; Q9M0F8; -.
DR STRING; 3702.AT4G29230.1; -.
DR PaxDb; Q9M0F8; -.
DR ProteomicsDB; 251235; -.
DR EnsemblPlants; AT4G29230.1; AT4G29230.1; AT4G29230.
DR GeneID; 829044; -.
DR Gramene; AT4G29230.1; AT4G29230.1; AT4G29230.
DR KEGG; ath:AT4G29230; -.
DR Araport; AT4G29230; -.
DR TAIR; locus:2118264; AT4G29230.
DR eggNOG; ENOG502QQ7W; Eukaryota.
DR HOGENOM; CLU_025101_3_0_1; -.
DR InParanoid; Q9M0F8; -.
DR OMA; LEEHQMC; -.
DR OrthoDB; 638414at2759; -.
DR PhylomeDB; Q9M0F8; -.
DR PRO; PR:Q9M0F8; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9M0F8; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0010321; P:regulation of vegetative phase change; IMP:TAIR.
DR GO; GO:1905177; P:tracheary element differentiation; IMP:UniProtKB.
DR Gene3D; 2.170.150.80; -; 1.
DR InterPro; IPR003441; NAC-dom.
DR InterPro; IPR036093; NAC_dom_sf.
DR InterPro; IPR044799; SOG1-like.
DR PANTHER; PTHR31079; PTHR31079; 1.
DR Pfam; PF02365; NAM; 1.
DR SUPFAM; SSF101941; SSF101941; 1.
DR PROSITE; PS51005; NAC; 1.
PE 2: Evidence at transcript level;
KW Activator; Cell wall biogenesis/degradation; Developmental protein;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..498
FT /note="NAC domain-containing protein 75"
FT /id="PRO_0000442295"
FT DOMAIN 48..215
FT /note="NAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT DNA_BIND 166..221
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT REGION 225..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..371
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 498 AA; 54873 MW; B06B4FE248D94F6B CRC64;
MNKSNPAGSV TGSDIIDAKI EEHQLCGSKK CPSCGHKLEG KPQDWVGLPA GVKFDPTDQE
LIEHLEAKVL AKDFKSHPLI DEFIPTIEGE DGICYTHPEK LPGVTRDGLS RHFFHRPSKA
YTTGTRKRRK IQTECDNNLQ GSSSSGETRW HKTGKTRPVM VNGKQKGCKK ILVLYTNFGK
NRKPEKTNWV MHQYHLGTHE EEKEGELVVS KIFYQTQPRQ CNWSSSTSSL NAIGGGGGEA
SSGGGGGEYH MRRDSGTTSG GSCSSSREII NVNPPNRSDE IGGVGGGVMA VAAAAAAVAA
GLPSYAMDQL SFVPFMKSFD EVARRETPQT GHATCEDVMA EQHRHRHQPS SSTSHHMAHD
HHHHHHQQQQ QRHHAFNISQ PTHPISTIIS PSTSLHHASI NILDDNPYHV HRILLPNENY
QTQQQLRQEG EEEHNDGKMG GRSASGLEEL IMGCTSSTTH HDVKDGSSSM GNQQEAEWLK
YSTFWPAPDS SDNQDHHG
