NAC7_ARATH
ID NAC7_ARATH Reviewed; 395 AA.
AC Q9FWX2; A1L4X4;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 2.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=NAC domain-containing protein 7 {ECO:0000303|PubMed:15029955};
DE Short=ANAC007 {ECO:0000303|PubMed:15029955};
DE AltName: Full=Protein EMBRYO DEFECTIVE 2749 {ECO:0000303|Ref.7};
DE AltName: Full=Protein VASCULAR RELATED NAC-DOMAIN 4 {ECO:0000303|PubMed:16103214};
GN Name=NAC007 {ECO:0000303|PubMed:15029955};
GN Synonyms=EMB2749 {ECO:0000303|Ref.7}, VND4 {ECO:0000303|PubMed:16103214};
GN OrderedLocusNames=At1g12260 {ECO:0000312|Araport:AT1G12260};
GN ORFNames=T28K15.1 {ECO:0000312|EMBL:AAG12568.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15029955; DOI=10.1093/dnares/10.6.239;
RA Ooka H., Satoh K., Doi K., Nagata T., Otomo Y., Murakami K., Matsubara K.,
RA Osato N., Kawai J., Carninci P., Hayashizaki Y., Suzuki K., Kojima K.,
RA Takahara Y., Yamamoto K., Kikuchi S.;
RT "Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis
RT thaliana.";
RL DNA Res. 10:239-247(2003).
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, GENE FAMILY, AND
RP NOMENCLATURE.
RX PubMed=16103214; DOI=10.1101/gad.1331305;
RA Kubo M., Udagawa M., Nishikubo N., Horiguchi G., Yamaguchi M., Ito J.,
RA Mimura T., Fukuda H., Demura T.;
RT "Transcription switches for protoxylem and metaxylem vessel formation.";
RL Genes Dev. 19:1855-1860(2005).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=17565617; DOI=10.1111/j.1365-313x.2007.03109.x;
RA Ko J.-H., Yang S.H., Park A.H., Lerouxel O., Han K.-H.;
RT "ANAC012, a member of the plant-specific NAC transcription factor family,
RT negatively regulates xylary fiber development in Arabidopsis thaliana.";
RL Plant J. 50:1035-1048(2007).
RN [7]
RP DISRUPTION PHENOTYPE.
RA Muralla R., Sweeney C., Lloyd J., Meinke D., Dickerman A.;
RT "The Arabidopsis SeedGenes project: approaching saturation for essential
RT genes.";
RL (In) Abstracts of the 19th international conference on Arabidopsis
RL research, pp.219-219, Montreal (2008).
RN [8]
RP TISSUE SPECIFICITY.
RX PubMed=18445131; DOI=10.1111/j.1365-313x.2008.03533.x;
RA Yamaguchi M., Kubo M., Fukuda H., Demura T.;
RT "Vascular-related NAC-DOMAIN7 is involved in the differentiation of all
RT types of xylem vessels in Arabidopsis roots and shoots.";
RL Plant J. 55:652-664(2008).
RN [9]
RP INTERACTION WITH NAC083/VNI2.
RX PubMed=20388856; DOI=10.1105/tpc.108.064048;
RA Yamaguchi M., Ohtani M., Mitsuda N., Kubo M., Ohme-Takagi M., Fukuda H.,
RA Demura T.;
RT "VND-INTERACTING2, a NAC domain transcription factor, negatively regulates
RT xylem vessel formation in Arabidopsis.";
RL Plant Cell 22:1249-1263(2010).
RN [10]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=25148240; DOI=10.1371/journal.pone.0105726;
RA Zhou J., Zhong R., Ye Z.-H.;
RT "Arabidopsis NAC domain proteins, VND1 to VND5, are transcriptional
RT regulators of secondary wall biosynthesis in vessels.";
RL PLoS ONE 9:E105726-E105726(2014).
CC -!- FUNCTION: Transcription activator that binds to the secondary wall NAC
CC binding element (SNBE), 5'-
CC (T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of
CC target genes (By similarity). Involved in xylem formation by promoting
CC the expression of secondary wall-associated transcription factors and
CC of genes involved in secondary wall biosynthesis and programmed cell
CC death, genes driven by the secondary wall NAC binding element (SNBE).
CC Triggers thickening of secondary walls (PubMed:16103214,
CC PubMed:25148240). {ECO:0000250|UniProtKB:Q9LVA1,
CC ECO:0000269|PubMed:16103214, ECO:0000269|PubMed:25148240}.
CC -!- SUBUNIT: Interacts with NAC083/VNI2. {ECO:0000269|PubMed:20388856}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9C8W9,
CC ECO:0000255|PROSITE-ProRule:PRU00353}.
CC -!- TISSUE SPECIFICITY: Expressed in root, shoot and hypocotyl vascular
CC elements, columella root caps, epidermal and cortex root cells and
CC root-hypocotyl junctions. Observed predominantly in root imature xylem
CC vessels (PubMed:18445131). Present in root developing xylems
CC (PubMed:16103214, PubMed:17565617). Specifically expressed in vessels
CC in the secondary xylem of the root-hypocotyl region, and in vessels but
CC not in interfascicular fibers in stems (PubMed:25148240).
CC {ECO:0000269|PubMed:16103214, ECO:0000269|PubMed:17565617,
CC ECO:0000269|PubMed:18445131, ECO:0000269|PubMed:25148240}.
CC -!- DEVELOPMENTAL STAGE: Up-regulated during xylem vessel element
CC formation. Expressed preferentially in procambial cells adjacent to
CC root meristem. {ECO:0000269|PubMed:16103214,
CC ECO:0000269|PubMed:25148240}.
CC -!- DOMAIN: The NAC domain includes a DNA binding domain and a dimerization
CC domain. {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC -!- DISRUPTION PHENOTYPE: Embryo deffective. {ECO:0000269|Ref.7}.
CC -!- SIMILARITY: Belongs to the plant vascular related NAC-domain protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG12568.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC022522; AAG12568.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28859.1; -; Genomic_DNA.
DR EMBL; BT029761; ABM06031.1; -; mRNA.
DR PIR; G86257; G86257.
DR RefSeq; NP_172690.1; NM_101098.5.
DR AlphaFoldDB; Q9FWX2; -.
DR SMR; Q9FWX2; -.
DR BioGRID; 23020; 1.
DR IntAct; Q9FWX2; 1.
DR STRING; 3702.AT1G12260.1; -.
DR PaxDb; Q9FWX2; -.
DR PRIDE; Q9FWX2; -.
DR EnsemblPlants; AT1G12260.1; AT1G12260.1; AT1G12260.
DR GeneID; 837780; -.
DR Gramene; AT1G12260.1; AT1G12260.1; AT1G12260.
DR KEGG; ath:AT1G12260; -.
DR Araport; AT1G12260; -.
DR TAIR; locus:2202028; AT1G12260.
DR eggNOG; ENOG502QT6P; Eukaryota.
DR HOGENOM; CLU_035664_1_2_1; -.
DR InParanoid; Q9FWX2; -.
DR OMA; PCKPELM; -.
DR OrthoDB; 688436at2759; -.
DR PhylomeDB; Q9FWX2; -.
DR PRO; PR:Q9FWX2; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FWX2; baseline and differential.
DR Genevisible; Q9FWX2; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:1901348; P:positive regulation of secondary cell wall biogenesis; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:TAIR.
DR GO; GO:0048759; P:xylem vessel member cell differentiation; IMP:TAIR.
DR Gene3D; 2.170.150.80; -; 1.
DR InterPro; IPR003441; NAC-dom.
DR InterPro; IPR036093; NAC_dom_sf.
DR Pfam; PF02365; NAM; 1.
DR SUPFAM; SSF101941; SSF101941; 1.
DR PROSITE; PS51005; NAC; 1.
PE 1: Evidence at protein level;
KW Activator; Cell wall biogenesis/degradation; Developmental protein;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..395
FT /note="NAC domain-containing protein 7"
FT /id="PRO_0000376615"
FT DOMAIN 7..156
FT /note="NAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT DNA_BIND 107..162
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT REGION 344..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 395 AA; 45841 MW; 940618F84DD86A8A CRC64;
MNSFSHVPPG FRFHPTDEEL VDYYLRKKVA SKRIEIDFIK DIDLYKIEPW DLQELCKIGH
EEQSDWYFFS HKDKKYPTGT RTNRATKAGF WKATGRDKAI YLRHSLIGMR KTLVFYKGRA
PNGQKSDWIM HEYRLETDEN GTPQEEGWVV CRVFKKRLAA VRRMGDYDSS PSHWYDDQLS
FMASELETNG QRRILPNHHQ QQQHEHQQHM PYGLNASAYA LNNPNLQCKQ ELELHYNHLV
QRNHLLDESH LSFLQLPQLE SPKIQQDNSN CNSLPYGTSN IDNNSSHNAN LQQSNIAHEE
QLNQGNQNFS SLYMNSGNEQ VMDQVTDWRV LDKFVASQLS NEEAATASAS IQNNAKDTSN
AEYQVDEEKD PKRASDMGEE YTASTSSSCQ IDLWK
