NACA2_ARATH
ID NACA2_ARATH Reviewed; 217 AA.
AC Q94JX9; Q9S7G0;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Nascent polypeptide-associated complex subunit alpha-like protein 2;
DE Short=NAC-alpha-like protein 2;
DE AltName: Full=Alpha-NAC-like protein 2;
GN OrderedLocusNames=At3g49470; ORFNames=T9C5.70;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: May promote appropriate targeting of ribosome-nascent
CC polypeptide complexes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NAC-alpha family. {ECO:0000305}.
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DR EMBL; AC012329; AAG52192.1; -; Genomic_DNA.
DR EMBL; AL132964; CAB62452.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78547.1; -; Genomic_DNA.
DR EMBL; AF370545; AAK48972.1; -; mRNA.
DR EMBL; AY072536; AAL66951.1; -; mRNA.
DR PIR; T46225; T46225.
DR RefSeq; NP_190516.1; NM_114807.5.
DR AlphaFoldDB; Q94JX9; -.
DR SMR; Q94JX9; -.
DR BioGRID; 9427; 8.
DR IntAct; Q94JX9; 4.
DR STRING; 3702.AT3G49470.1; -.
DR iPTMnet; Q94JX9; -.
DR PaxDb; Q94JX9; -.
DR PRIDE; Q94JX9; -.
DR ProteomicsDB; 248923; -.
DR EnsemblPlants; AT3G49470.1; AT3G49470.1; AT3G49470.
DR GeneID; 824109; -.
DR Gramene; AT3G49470.1; AT3G49470.1; AT3G49470.
DR KEGG; ath:AT3G49470; -.
DR Araport; AT3G49470; -.
DR TAIR; locus:2114703; AT3G49470.
DR eggNOG; KOG2239; Eukaryota.
DR HOGENOM; CLU_057806_3_0_1; -.
DR InParanoid; Q94JX9; -.
DR OMA; LVMCQAN; -.
DR PhylomeDB; Q94JX9; -.
DR PRO; PR:Q94JX9; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q94JX9; baseline and differential.
DR Genevisible; Q94JX9; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0005854; C:nascent polypeptide-associated complex; IEA:InterPro.
DR GO; GO:0003729; F:mRNA binding; IDA:TAIR.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR Gene3D; 2.20.70.30; -; 1.
DR InterPro; IPR016641; EGD2/NACA.
DR InterPro; IPR044034; NAC-like_UBA.
DR InterPro; IPR038187; NAC_A/B_dom_sf.
DR InterPro; IPR002715; Nas_poly-pep-assoc_cplx_dom.
DR PANTHER; PTHR21713; PTHR21713; 1.
DR Pfam; PF19026; HYPK_UBA; 1.
DR Pfam; PF01849; NAC; 1.
DR SMART; SM01407; NAC; 1.
DR PROSITE; PS51151; NAC_AB; 1.
PE 2: Evidence at transcript level;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..217
FT /note="Nascent polypeptide-associated complex subunit
FT alpha-like protein 2"
FT /id="PRO_0000135588"
FT DOMAIN 70..135
FT /note="NAC-A/B"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00507"
FT DOMAIN 178..215
FT /note="UBA"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..60
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 144
FT /note="R -> K (in Ref. 3; AAK48972/AAL66951)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 217 AA; 23712 MW; 97DE777D351E5C35 CRC64;
MSPPPAVVTE SADGQPEQPP VTAIAEELEK KLQTDEPIVE DVKDDEDDDD DDEEEEDDDA
QGVSGSSKQS RSEKKSRKAM LKLGMKPVTG VSRVTIKRTK NVLFFISKPD VFKSPHSETY
VIFGEAKIED LSSQLQTQAA QQFRMPEIGA TSQRAEASTA TVEAQVEEDE EEIDETGVEA
RDIDLVMTQA GVSRSKAVKA LKSHDGDIVS AIMELTT
