NACA5_ARATH
ID NACA5_ARATH Reviewed; 209 AA.
AC Q8LGC6; Q9MAN9;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Nascent polypeptide-associated complex subunit alpha-like protein 5;
DE Short=NAC-alpha-like protein 5;
DE AltName: Full=Alpha-NAC-like protein 5;
GN OrderedLocusNames=At1g33040; ORFNames=F9L11.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May promote appropriate targeting of ribosome-nascent
CC polypeptide complexes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NAC-alpha family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC006424; AAF31282.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31552.1; -; Genomic_DNA.
DR EMBL; AY045682; AAK74040.1; -; mRNA.
DR EMBL; AY059164; AAL15389.1; -; mRNA.
DR EMBL; AY084346; AAM60929.1; -; mRNA.
DR PIR; A86455; A86455.
DR RefSeq; NP_564415.1; NM_103037.4.
DR AlphaFoldDB; Q8LGC6; -.
DR SMR; Q8LGC6; -.
DR BioGRID; 25433; 6.
DR IntAct; Q8LGC6; 2.
DR STRING; 3702.AT1G33040.1; -.
DR MetOSite; Q8LGC6; -.
DR PaxDb; Q8LGC6; -.
DR PRIDE; Q8LGC6; -.
DR ProteomicsDB; 251279; -.
DR EnsemblPlants; AT1G33040.1; AT1G33040.1; AT1G33040.
DR GeneID; 840199; -.
DR Gramene; AT1G33040.1; AT1G33040.1; AT1G33040.
DR KEGG; ath:AT1G33040; -.
DR Araport; AT1G33040; -.
DR TAIR; locus:2206975; AT1G33040.
DR eggNOG; KOG2239; Eukaryota.
DR HOGENOM; CLU_057806_3_0_1; -.
DR InParanoid; Q8LGC6; -.
DR OMA; FKMPDMA; -.
DR OrthoDB; 1331328at2759; -.
DR PhylomeDB; Q8LGC6; -.
DR PRO; PR:Q8LGC6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8LGC6; baseline and differential.
DR Genevisible; Q8LGC6; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005854; C:nascent polypeptide-associated complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; HDA:TAIR.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR Gene3D; 2.20.70.30; -; 1.
DR InterPro; IPR016641; EGD2/NACA.
DR InterPro; IPR044034; NAC-like_UBA.
DR InterPro; IPR038187; NAC_A/B_dom_sf.
DR InterPro; IPR002715; Nas_poly-pep-assoc_cplx_dom.
DR PANTHER; PTHR21713; PTHR21713; 1.
DR Pfam; PF19026; HYPK_UBA; 1.
DR Pfam; PF01849; NAC; 1.
DR SMART; SM01407; NAC; 1.
DR PROSITE; PS51151; NAC_AB; 1.
PE 2: Evidence at transcript level;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..209
FT /note="Nascent polypeptide-associated complex subunit
FT alpha-like protein 5"
FT /id="PRO_0000135591"
FT DOMAIN 62..127
FT /note="NAC-A/B"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00507"
FT DOMAIN 170..207
FT /note="UBA"
FT REGION 23..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..52
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..71
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 204
FT /note="I -> V (in Ref. 4; AAM60929)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 209 AA; 22780 MW; 9A3CBE3AA49A270B CRC64;
MPGAIVEEEK SQIESIKEQL KLEKEDDVVV EDVKDGEEED DDEDDEDVEV EGEGGNENAK
QSRSEKKSRK AVLKLGMKPV SDVSRVTIKR AKNVLFVISK PDVYKSPNAE TYVIFGEAKV
DDLSSQLQTQ AAQRFKMPDV TSMLPNAGSE ATMAPLAEEE DEDDVDDTGV EARDIDLVMT
QAGVSKAKAV SALKANDGDI VSAIMELTT
