ID   NACA_CAEBR              Reviewed;         197 AA.
AC   Q61UX1; A8WZ82;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Nascent polypeptide-associated complex subunit alpha;
DE            Short=NAC-alpha;
DE   AltName: Full=Alpha-NAC;
GN   Name=icd-2 {ECO:0000312|WormBase:CBG05114};
GN   ORFNames=CBG05114 {ECO:0000312|WormBase:CBG05114};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: May promote appropriate targeting of ribosome-nascent
CC       polypeptide complexes. {ECO:0000250|UniProtKB:Q13765}.
CC   -!- SIMILARITY: Belongs to the NAC-alpha family. {ECO:0000305}.
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DR   EMBL; HE600988; CAP25692.1; -; Genomic_DNA.
DR   RefSeq; XP_002638770.1; XM_002638724.1.
DR   AlphaFoldDB; Q61UX1; -.
DR   SMR; Q61UX1; -.
DR   STRING; 6238.CBG05114; -.
DR   EnsemblMetazoa; CBG05114.1; CBG05114.1; WBGene00027644.
DR   GeneID; 8580765; -.
DR   KEGG; cbr:CBG_05114; -.
DR   CTD; 8580765; -.
DR   WormBase; CBG05114; CBP06992; WBGene00027644; Cbr-icd-2.
DR   eggNOG; KOG2239; Eukaryota.
DR   HOGENOM; CLU_057806_1_0_1; -.
DR   InParanoid; Q61UX1; -.
DR   OMA; SDAYIVF; -.
DR   OrthoDB; 1331328at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005854; C:nascent polypeptide-associated complex; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR   Gene3D; 2.20.70.30; -; 1.
DR   InterPro; IPR016641; EGD2/NACA.
DR   InterPro; IPR044034; NAC-like_UBA.
DR   InterPro; IPR038187; NAC_A/B_dom_sf.
DR   InterPro; IPR002715; Nas_poly-pep-assoc_cplx_dom.
DR   PANTHER; PTHR21713; PTHR21713; 1.
DR   Pfam; PF19026; HYPK_UBA; 1.
DR   Pfam; PF01849; NAC; 1.
DR   PIRSF; PIRSF015901; NAC_alpha; 1.
DR   SMART; SM01407; NAC; 1.
DR   PROSITE; PS51151; NAC_AB; 1.
PE   3: Inferred from homology;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..197
FT                   /note="Nascent polypeptide-associated complex subunit
FT                   alpha"
FT                   /id="PRO_0000135584"
FT   DOMAIN          58..123
FT                   /note="NAC-A/B"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00507"
FT   DOMAIN          158..195
FT                   /note="UBA"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          134..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   197 AA;  22025 MW;  B2A9C1590C492080 CRC64;
     MTGSTETRHN EKDVKEPQVD SDADSDNEAI EHQLTEEQRR VAEAAGLGDH IDKQAKQSRS
     EKKARKLFSK LGLKQVTGVS RVCIRKSKNI LFVINKPDVF KSPGSDTYII FGEAKIEDLT
     QHAQMSAIEN MKPTREAPQL KTVEEDDNED VEEDSTGIEE KDIELVISQA NTTRNKAIRA
     LKDADNDIVN AIMSLTM