ID   NACA_DANRE              Reviewed;         215 AA.
AC   Q8JIU7; Q0P3U9;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Nascent polypeptide-associated complex subunit alpha;
DE            Short=NAC-alpha;
DE   AltName: Full=Alpha-NAC;
GN   Name=naca;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Amsterdam A., Burgess S., Golling G., Chen W., Sun Z., Townsend K.,
RA   Farrington S., Haldi M., Hopkins N.;
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RC   TISSUE=Embryo;
RX   PubMed=18307296; DOI=10.1021/pr700667w;
RA   Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J.,
RA   Slijper M., Heck A.J.R.;
RT   "Online automated in vivo zebrafish phosphoproteomics: from large-scale
RT   analysis down to a single embryo.";
RL   J. Proteome Res. 7:1555-1564(2008).
CC   -!- FUNCTION: May promote appropriate targeting of ribosome-nascent
CC       polypeptide complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NAC-alpha family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY099510; AAM21714.1; -; mRNA.
DR   EMBL; AY398384; AAQ97817.1; -; mRNA.
DR   EMBL; BC122432; AAI22433.1; -; mRNA.
DR   RefSeq; NP_001180281.1; NM_001193352.1.
DR   RefSeq; NP_775371.1; NM_173264.2.
DR   AlphaFoldDB; Q8JIU7; -.
DR   SMR; Q8JIU7; -.
DR   BioGRID; 79752; 1.
DR   iPTMnet; Q8JIU7; -.
DR   PaxDb; Q8JIU7; -.
DR   Ensembl; ENSDART00000014723; ENSDARP00000025953; ENSDARG00000005513.
DR   GeneID; 195823; -.
DR   KEGG; dre:195823; -.
DR   CTD; 4666; -.
DR   ZFIN; ZDB-GENE-020423-4; naca.
DR   eggNOG; KOG2239; Eukaryota.
DR   GeneTree; ENSGT00440000033468; -.
DR   HOGENOM; CLU_057806_1_2_1; -.
DR   InParanoid; Q8JIU7; -.
DR   OrthoDB; 1331328at2759; -.
DR   PhylomeDB; Q8JIU7; -.
DR   TreeFam; TF313348; -.
DR   PRO; PR:Q8JIU7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 23.
DR   Bgee; ENSDARG00000005513; Expressed in pharyngeal gill and 27 other tissues.
DR   ExpressionAtlas; Q8JIU7; baseline.
DR   GO; GO:0005737; C:cytoplasm; IDA:ZFIN.
DR   GO; GO:0005854; C:nascent polypeptide-associated complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IDA:ZFIN.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0060216; P:definitive hemopoiesis; IMP:ZFIN.
DR   GO; GO:0030239; P:myofibril assembly; IMP:ZFIN.
DR   GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR   Gene3D; 2.20.70.30; -; 1.
DR   InterPro; IPR016641; EGD2/NACA.
DR   InterPro; IPR044034; NAC-like_UBA.
DR   InterPro; IPR038187; NAC_A/B_dom_sf.
DR   InterPro; IPR002715; Nas_poly-pep-assoc_cplx_dom.
DR   PANTHER; PTHR21713; PTHR21713; 1.
DR   Pfam; PF19026; HYPK_UBA; 1.
DR   Pfam; PF01849; NAC; 1.
DR   SMART; SM01407; NAC; 1.
DR   PROSITE; PS51151; NAC_AB; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..215
FT                   /note="Nascent polypeptide-associated complex subunit
FT                   alpha"
FT                   /id="PRO_0000135580"
FT   DOMAIN          70..135
FT                   /note="NAC-A/B"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00507"
FT   DOMAIN          176..213
FT                   /note="UBA"
FT   REGION          1..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..31
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..80
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         166
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18307296"
SQ   SEQUENCE   215 AA;  23400 MW;  1648F07C49FC7FE6 CRC64;
     MPGEATETVP VTEQEMQQPQ AETGSGTESD SDESVPDLEE GDSAQTQTQQ AQLAAAAEID
     EEPVSKAKQS RSEKKARKAM SKLGLRQVAG VTRVTIRKSK NILFVITKPD VYKSPASDTY
     IVFGEAKIED LSQQAQLAAA EKFKVQGEAV SNIQENTQTP TVQEESEEEE VDETGVEVKD
     IELVMSQANV SRAKAVRALK NNNNDIVNAI MELTM