ID   NACA_ENCCU              Reviewed;         157 AA.
AC   Q8SWB5;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Nascent polypeptide-associated complex subunit alpha;
DE            Short=NAC-alpha;
DE   AltName: Full=Alpha-NAC;
GN   Name=EGD2; OrderedLocusNames=ECU02_1050;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
CC   -!- FUNCTION: May be involved in mitochondrial protein import by enhancing
CC       productive ribosome interactions with the outer mitochondrial membrane
CC       and blocks the inappropriate interaction of ribosomes translating non-
CC       secretory nascent polypeptides with translocation sites in the membrane
CC       of the endoplasmic reticulum. EGD2 may also be involved in
CC       transcription regulation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Predominantly cytoplasmic, may also transiently localize to the
CC       nucleus. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NAC-alpha family. {ECO:0000305}.
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DR   EMBL; AL590442; CAD25134.1; -; Genomic_DNA.
DR   RefSeq; NP_584630.1; NM_001040819.1.
DR   AlphaFoldDB; Q8SWB5; -.
DR   SMR; Q8SWB5; -.
DR   STRING; 284813.Q8SWB5; -.
DR   GeneID; 858620; -.
DR   KEGG; ecu:ECU02_1050; -.
DR   VEuPathDB; MicrosporidiaDB:ECU02_1050; -.
DR   HOGENOM; CLU_140492_0_0_1; -.
DR   InParanoid; Q8SWB5; -.
DR   OrthoDB; 1581809at2759; -.
DR   Proteomes; UP000000819; Chromosome II.
DR   GO; GO:0005854; C:nascent polypeptide-associated complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR016641; EGD2/NACA.
DR   InterPro; IPR002715; Nas_poly-pep-assoc_cplx_dom.
DR   PIRSF; PIRSF015901; NAC_alpha; 1.
DR   PROSITE; PS51151; NAC_AB; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..157
FT                   /note="Nascent polypeptide-associated complex subunit
FT                   alpha"
FT                   /id="PRO_0000273490"
FT   DOMAIN          6..71
FT                   /note="NAC-A/B"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00507"
FT   DOMAIN          118..157
FT                   /note="UBA"
FT   REGION          81..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   157 AA;  17517 MW;  96E3B3638DEA8643 CRC64;
     MARALTTDES HIHKTLGAKV GLEEVEAVER IAIVVKDTRY SVESPVAYRI KGTDSILIFG
     DLGSPVNLHQ LKRMYEDSIR SSKDQEGPGL YDEIHSDPQE DGVKEAEEIT VDPSDERLSE
     EDIKLISSQV KASRNDIIKA LVESEYDVVD AMMKLTK