ID   NACA_ORENI              Reviewed;         215 AA.
AC   Q8AWF2;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Nascent polypeptide-associated complex subunit alpha;
DE            Short=NAC-alpha;
DE   AltName: Full=Alpha-NAC;
GN   Name=naca;
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Praveen K., Evans D.L., Jaso-Friedmann L.;
RT   "Expression of nascent polypeptide-associated complex alpha polypeptide
RT   (naca) in activated non-specific cytotoxic cells.";
RL   Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May promote appropriate targeting of ribosome-nascent
CC       polypeptide complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NAC-alpha family. {ECO:0000305}.
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DR   EMBL; AY168640; AAN86982.1; -; mRNA.
DR   RefSeq; XP_003439022.1; XM_003438974.3.
DR   RefSeq; XP_005448688.1; XM_005448631.1.
DR   AlphaFoldDB; Q8AWF2; -.
DR   SMR; Q8AWF2; -.
DR   STRING; 8128.ENSONIP00000021508; -.
DR   Ensembl; ENSONIT00000021527; ENSONIP00000021508; ENSONIG00000017056.
DR   GeneID; 100534485; -.
DR   KEGG; onl:100534485; -.
DR   CTD; 4666; -.
DR   eggNOG; KOG2239; Eukaryota.
DR   GeneTree; ENSGT00940000161501; -.
DR   InParanoid; Q8AWF2; -.
DR   OrthoDB; 453320at2759; -.
DR   Proteomes; UP000005207; Linkage group LG20.
DR   GO; GO:0005854; C:nascent polypeptide-associated complex; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.70.30; -; 1.
DR   InterPro; IPR016641; EGD2/NACA.
DR   InterPro; IPR044034; NAC-like_UBA.
DR   InterPro; IPR038187; NAC_A/B_dom_sf.
DR   InterPro; IPR002715; Nas_poly-pep-assoc_cplx_dom.
DR   PANTHER; PTHR21713; PTHR21713; 1.
DR   Pfam; PF19026; HYPK_UBA; 1.
DR   Pfam; PF01849; NAC; 1.
DR   PIRSF; PIRSF015901; NAC_alpha; 1.
DR   SMART; SM01407; NAC; 1.
DR   PROSITE; PS51151; NAC_AB; 1.
PE   2: Evidence at transcript level;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..215
FT                   /note="Nascent polypeptide-associated complex subunit
FT                   alpha"
FT                   /id="PRO_0000135581"
FT   DOMAIN          70..135
FT                   /note="NAC-A/B"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00507"
FT   DOMAIN          176..213
FT                   /note="UBA"
FT   REGION          1..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..31
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..80
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   215 AA;  23514 MW;  338F46DDDB49FFC1 CRC64;
     MPGEATETVP VTEQEMQQPQ VETGSGTESD SDDSVPELEE QDSAQTQTQQ AQLAAAAEID
     EEPVSKAKQS RSEKKARKAM SKLGLRQVTG VTRVTIRKSK NILFVITKPD VYKSPASDTY
     IVFGEAKIED LSQQAQLAAA EKFKVPGETV SNVQENTQTP TVQEESEEEE VDETGVEVKD
     IELVMSQANV SRAKAVRALK NNNNDIVNAI MELTM