ID   NACA_XENLA              Reviewed;         213 AA.
AC   Q6IP73;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Nascent polypeptide-associated complex subunit alpha;
DE            Short=NAC-alpha;
DE   AltName: Full=Alpha-NAC;
GN   Name=naca;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May promote appropriate targeting of ribosome-nascent
CC       polypeptide complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NAC-alpha family. {ECO:0000305}.
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DR   EMBL; BC072044; AAH72044.1; -; mRNA.
DR   RefSeq; NP_001085386.1; NM_001091917.1.
DR   AlphaFoldDB; Q6IP73; -.
DR   SMR; Q6IP73; -.
DR   DNASU; 443812; -.
DR   GeneID; 443812; -.
DR   KEGG; xla:443812; -.
DR   CTD; 443812; -.
DR   Xenbase; XB-GENE-969068; naca.S.
DR   OrthoDB; 1367188at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 443812; Expressed in spleen and 19 other tissues.
DR   GO; GO:0005854; C:nascent polypeptide-associated complex; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.70.30; -; 1.
DR   InterPro; IPR016641; EGD2/NACA.
DR   InterPro; IPR044034; NAC-like_UBA.
DR   InterPro; IPR038187; NAC_A/B_dom_sf.
DR   InterPro; IPR002715; Nas_poly-pep-assoc_cplx_dom.
DR   PANTHER; PTHR21713; PTHR21713; 1.
DR   Pfam; PF19026; HYPK_UBA; 1.
DR   Pfam; PF01849; NAC; 1.
DR   PIRSF; PIRSF015901; NAC_alpha; 1.
DR   SMART; SM01407; NAC; 1.
DR   PROSITE; PS51151; NAC_AB; 1.
PE   2: Evidence at transcript level;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..213
FT                   /note="Nascent polypeptide-associated complex subunit
FT                   alpha"
FT                   /id="PRO_0000135582"
FT   DOMAIN          68..133
FT                   /note="NAC-A/B"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00507"
FT   DOMAIN          174..211
FT                   /note="UBA"
FT   REGION          1..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..78
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   213 AA;  23206 MW;  69BD92BF7D746D7F CRC64;
     MPGEATETVP AAEQELHQPQ VESGSGTESD SDDSPPELEQ DTQTTTQQAQ LAAAAEIDEE
     PVSKAKQSRS EKKARKAMSK LGLRQVTGVT RVTIRKSKNI LFVITKPDVY KSPASDTYIV
     FGEAKIEDLS QQAQLAAAEK FKVQGETVSN IQENTQTPTV QEESEEEEVD EAGVEVKDIE
     LVMSQANVSR AKAVRALKNN SNDIVNAIME LTM