ID   NACA_XENTR              Reviewed;         214 AA.
AC   Q68F90;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Nascent polypeptide-associated complex subunit alpha;
DE            Short=NAC-alpha;
DE   AltName: Full=Alpha-NAC;
GN   Name=naca;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May promote appropriate targeting of ribosome-nascent
CC       polypeptide complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NAC-alpha family. {ECO:0000305}.
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DR   EMBL; BC079953; AAH79953.1; -; mRNA.
DR   RefSeq; NP_001007513.1; NM_001007512.1.
DR   AlphaFoldDB; Q68F90; -.
DR   SMR; Q68F90; -.
DR   PaxDb; Q68F90; -.
DR   DNASU; 493239; -.
DR   GeneID; 493239; -.
DR   KEGG; xtr:493239; -.
DR   CTD; 4666; -.
DR   Xenbase; XB-GENE-969062; naca.
DR   eggNOG; KOG2239; Eukaryota.
DR   InParanoid; Q68F90; -.
DR   OrthoDB; 1331328at2759; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005854; C:nascent polypeptide-associated complex; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR   Gene3D; 2.20.70.30; -; 1.
DR   InterPro; IPR016641; EGD2/NACA.
DR   InterPro; IPR044034; NAC-like_UBA.
DR   InterPro; IPR038187; NAC_A/B_dom_sf.
DR   InterPro; IPR002715; Nas_poly-pep-assoc_cplx_dom.
DR   PANTHER; PTHR21713; PTHR21713; 1.
DR   Pfam; PF19026; HYPK_UBA; 1.
DR   Pfam; PF01849; NAC; 1.
DR   PIRSF; PIRSF015901; NAC_alpha; 1.
DR   SMART; SM01407; NAC; 1.
DR   PROSITE; PS51151; NAC_AB; 1.
PE   2: Evidence at transcript level;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..214
FT                   /note="Nascent polypeptide-associated complex subunit
FT                   alpha"
FT                   /id="PRO_0000135583"
FT   DOMAIN          69..134
FT                   /note="NAC-A/B"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00507"
FT   DOMAIN          175..212
FT                   /note="UBA"
FT   REGION          1..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..79
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   214 AA;  23279 MW;  91B5259F31005B5A CRC64;
     MPGEATETVP AAEQELHQPQ AETGSGTESD SDDSPPELEQ DSTQTTTQQA QLAAAAEIDE
     EPVSKAKQSR SEKKARKAMS KLGLRQVTGV TRVTIRKSKN ILFVITKPDV YKSPASDTYI
     VFGEAKIEDL SQQAQLAAAE KFKVQGEAVS NIQENTQTPT VQEESEEEEV DETGVEVKDI
     ELVMSQANVS RAKAVRALKN NSNDIVNAIM ELTM