ID   NACH_DROAN              Reviewed;         516 AA.
AC   O61370;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Sodium channel protein Nach;
GN   Name=Nach;
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Tai 13-1610;
RA   Da Lage J.-L., Alland C.;
RL   Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of a complex that plays a role in tracheal liquid
CC       clearance. Probable role in sodium transport (By similarity).
CC       {ECO:0000250|UniProtKB:O61365}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000305}.
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DR   EMBL; AF024691; AAC39089.1; -; Genomic_DNA.
DR   AlphaFoldDB; O61370; -.
DR   STRING; 7217.FBpp0116649; -.
DR   eggNOG; KOG4294; Eukaryota.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0035002; P:liquid clearance, open tracheal system; ISS:UniProtKB.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR020903; ENaC_CS.
DR   PANTHER; PTHR11690; PTHR11690; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Ion channel; Ion transport; Membrane; Sodium; Sodium channel;
KW   Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..516
FT                   /note="Sodium channel protein Nach"
FT                   /id="PRO_0000181309"
FT   TOPO_DOM        1..49
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        71..452
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        453..473
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        474..516
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        128
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        165
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        220
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        348
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   516 AA;  59941 MW;  1EA6FDC2509EF40A CRC64;
     MGHEEELSPE QVDLKVSPLM GSLKRTWNDF CATSSIHGLR YTRDEDTNRI VHFVWLLISL
     VMFICAVVMA RTFYIDFRSN PTRMNVESDN TPVNTLYFPP VTICPDVLFN MQKSEAFLQT
     LQLPQGTNQS VILRKLHIFY GFMLDDEKYS EQDTSLMESL LSLNNLTLQQ LVEHLRWNCD
     EILYRCRFNG QIRDCLELFQ LSKTFFGHCC SFNLRQTGLN FTAERAVGGL KYGLSVILRY
     KDDSYDPVQS YSFGVKLLIQ ESDAFPSAHS SSKFIAFNSE VFAAIRPQET FCSPAVKALS
     IEDRNCVFRN EFKMRYFKNY VYPNCELNCR VTNMVKFCNC HTYFFDFNRT TDRICTFKDI
     PCLVDNFANI ISRKRSTQCY CPLTCEHLDY DVQISDFPLK LNMPVGDQFY SGINKNDGIL
     HVFINSFGYR RLRHDLLSNM VTLVSNLGSA FSLFVGMSML SVVEIMYYFS VILRKNYVLE
     CEARKKMLHK GPKFAWPKAN DSHSKHQKSV FIIHKM