ID   NACH_DROVI              Reviewed;         384 AA.
AC   Q9NJP2;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Sodium channel protein Nach;
DE   Flags: Fragment;
GN   Name=Nach;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244 {ECO:0000312|EMBL:AAF61426.1};
RN   [1] {ECO:0000312|EMBL:AAF61426.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Da Lage J.-L., Renard E., Chartois F., Cariou M.-L.;
RT   "Origin and evolution of the Amyrel gene in Drosophila.";
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of a complex that plays a role in tracheal liquid
CC       clearance. Probable role in sodium transport (By similarity).
CC       {ECO:0000250|UniProtKB:O61365}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000305}.
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DR   EMBL; AF136603; AAF61426.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9NJP2; -.
DR   SMR; Q9NJP2; -.
DR   STRING; 7244.FBpp0235773; -.
DR   eggNOG; KOG4294; Eukaryota.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0035002; P:liquid clearance, open tracheal system; ISS:UniProtKB.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR020903; ENaC_CS.
DR   PANTHER; PTHR11690; PTHR11690; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Ion channel; Ion transport; Membrane; Sodium; Sodium channel;
KW   Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           <1..384
FT                   /note="Sodium channel protein Nach"
FT                   /id="PRO_0000181311"
FT   TOPO_DOM        <1..319
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        341..384
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        32
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        215
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT                   /evidence="ECO:0000312|EMBL:AAF61426.1"
SQ   SEQUENCE   384 AA;  44775 MW;  85D4518F1EA7DF23 CRC64;
     AAFAYFSGFM LDDARFSPAE IELMESVLLD NNLTMVQFVD RLRWDCHELL HRCRYHGDIM
     DCTQLFQLSK TFFGHCCSFN LRQHGLDFTA QAAAGGLDNG LSLILRYKDE NYDALQSYSH
     GFKLLIQETD AFPSAHADCK FLGLNTESFA TLRVVETFCS EAVKSLPISQ RNCVFRHEFR
     LRYFSDYVYP NCELNCRAKN MVKLCGCHTY FFEFNRTKDR VCTFRDIPCL VDNFPDIITR
     RKKTQCNCPL TCEHFDYDVQ MSNFALMLNM PVVDPFYTGI ERNDAIVHIF LNSQVYRRVR
     VDLLSNMVTL VSHLGSAFSL FVGMSMLSLV EIIYYFTVIL RRNYVQECRA RQKLQTLHRR
     PNFGWPGDKN SNQQKSVFYI RGRN