ID   NAC_METJA               Reviewed;         128 AA.
AC   Q57728;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Nascent polypeptide-associated complex protein {ECO:0000255|HAMAP-Rule:MF_00814};
GN   Name=nac {ECO:0000255|HAMAP-Rule:MF_00814}; OrderedLocusNames=MJ0280;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Contacts the emerging nascent chain on the ribosome.
CC       {ECO:0000255|HAMAP-Rule:MF_00814}.
CC   -!- SUBUNIT: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.
CC       {ECO:0000255|HAMAP-Rule:MF_00814}.
CC   -!- SIMILARITY: Belongs to the NAC-alpha family. {ECO:0000255|HAMAP-
CC       Rule:MF_00814}.
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DR   EMBL; L77117; AAB98268.1; -; Genomic_DNA.
DR   PIR; A64335; A64335.
DR   RefSeq; WP_010869778.1; NC_000909.1.
DR   AlphaFoldDB; Q57728; -.
DR   SMR; Q57728; -.
DR   STRING; 243232.MJ_0280; -.
DR   EnsemblBacteria; AAB98268; AAB98268; MJ_0280.
DR   GeneID; 1451135; -.
DR   KEGG; mja:MJ_0280; -.
DR   eggNOG; arCOG04061; Archaea.
DR   HOGENOM; CLU_146475_1_0_2; -.
DR   InParanoid; Q57728; -.
DR   OMA; PRKMKQM; -.
DR   OrthoDB; 105165at2157; -.
DR   PhylomeDB; Q57728; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR   GO; GO:0050821; P:protein stabilization; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.20.70.30; -; 1.
DR   HAMAP; MF_00814; NAC_arch; 1.
DR   InterPro; IPR044034; NAC-like_UBA.
DR   InterPro; IPR038187; NAC_A/B_dom_sf.
DR   InterPro; IPR005231; NAC_arc.
DR   InterPro; IPR002715; Nas_poly-pep-assoc_cplx_dom.
DR   InterPro; IPR009060; UBA-like_sf.
DR   Pfam; PF19026; HYPK_UBA; 1.
DR   Pfam; PF01849; NAC; 1.
DR   SMART; SM01407; NAC; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   TIGRFAMs; TIGR00264; TIGR00264; 1.
DR   PROSITE; PS51151; NAC_AB; 1.
PE   3: Inferred from homology;
KW   Protein transport; Reference proteome; RNA-binding; Transport.
FT   CHAIN           1..128
FT                   /note="Nascent polypeptide-associated complex protein"
FT                   /id="PRO_0000135601"
FT   DOMAIN          8..75
FT                   /note="NAC-A/B"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00814"
SQ   SEQUENCE   128 AA;  14958 MW;  CE6B571273455E8D CRC64;
     MFPGKVNPRM LKKMQKMMKD FGMETEDLDV RKVIFVFDDE EWVFEEPKVQ VMDILGVKTY
     SITGKPKKIK KEKVEEEEEV KVEITEEDVE LVAKQCNVSK EEARKALEEC NGDIAEAILK
     LEEEKEEN