NAD1_CAEEL
ID NAD1_CAEEL Reviewed; 582 AA.
AC Q93655; Q86R86;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2004, sequence version 3.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Sodium-dependent low-affinity dicarboxylate transporter 1;
DE AltName: Full=Na(+)/dicarboxylate cotransporter 1;
DE Short=NaDC-1;
DE Short=ceNaDC1;
GN Name=nac-1; Synonyms=indy-1, nad-1; ORFNames=F31F6.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=Bristol N2;
RX PubMed=12480943; DOI=10.1074/jbc.m208763200;
RA Fei Y.-J., Inoue K., Ganapathy V.;
RT "Structural and functional characteristics of two sodium-coupled
RT dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis
RT elegans and their relevance to life span.";
RL J. Biol. Chem. 278:6136-6144(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Low affinity sodium-dicarboxylate cotransporter that accepts
CC a range of tricarboxylic acid-cycle intermediates with 4-5 carbon
CC atoms. There is no interaction with monocarboxylates.
CC {ECO:0000269|PubMed:12480943}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Nad-1 and nad-2 are coexpressed in the intestinal
CC tract from early larvae to adults, expression is from the pharynx
CC through to the anus. Expression level is significantly greater in the
CC anterior half of the intestine than in the posterior half.
CC {ECO:0000269|PubMed:12480943}.
CC -!- DEVELOPMENTAL STAGE: Not detected in the embryo. Expressed from early
CC larvae at a high level, levels decrease in later larvae and then
CC increase again at adult stages. {ECO:0000269|PubMed:12480943}.
CC -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC NADC subfamily. {ECO:0000305}.
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DR EMBL; AY090484; AAM11893.1; -; mRNA.
DR EMBL; Z69884; CAA93752.2; -; Genomic_DNA.
DR PIR; T21613; T21613.
DR RefSeq; NP_510473.2; NM_078072.3.
DR AlphaFoldDB; Q93655; -.
DR SMR; Q93655; -.
DR STRING; 6239.F31F6.6; -.
DR TCDB; 2.A.47.1.7; the divalent anion:na(+) symporter (dass) family.
DR iPTMnet; Q93655; -.
DR EPD; Q93655; -.
DR PaxDb; Q93655; -.
DR PeptideAtlas; Q93655; -.
DR EnsemblMetazoa; F31F6.6.1; F31F6.6.1; WBGene00003517.
DR GeneID; 181585; -.
DR KEGG; cel:CELE_F31F6.6; -.
DR UCSC; F31F6.6; c. elegans.
DR CTD; 181585; -.
DR WormBase; F31F6.6; CE34007; WBGene00003517; nac-1.
DR eggNOG; KOG1281; Eukaryota.
DR GeneTree; ENSGT01030000234550; -.
DR HOGENOM; CLU_005170_9_1_1; -.
DR InParanoid; Q93655; -.
DR OMA; IFAFPMV; -.
DR OrthoDB; 389981at2759; -.
DR PhylomeDB; Q93655; -.
DR Reactome; R-CEL-433137; Sodium-coupled sulphate, di- and tri-carboxylate transporters.
DR PRO; PR:Q93655; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00003517; Expressed in larva and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0015137; F:citrate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015361; F:low-affinity sodium:dicarboxylate symporter activity; IDA:WormBase.
DR GO; GO:0015141; F:succinate transmembrane transporter activity; IDA:WormBase.
DR GO; GO:0098656; P:anion transmembrane transport; IBA:GO_Central.
DR GO; GO:0015746; P:citrate transport; IBA:GO_Central.
DR GO; GO:0015744; P:succinate transport; IDA:WormBase.
DR InterPro; IPR031312; Na/sul_symport_CS.
DR InterPro; IPR001898; SLC13A/DASS.
DR Pfam; PF00939; Na_sulph_symp; 1.
DR PROSITE; PS01271; NA_SULFATE; 1.
PE 2: Evidence at transcript level;
KW Ion transport; Membrane; Reference proteome; Sodium; Sodium transport;
KW Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..582
FT /note="Sodium-dependent low-affinity dicarboxylate
FT transporter 1"
FT /id="PRO_0000172496"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 482..502
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 527..547
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 582 AA; 64186 MW; ECDE56055EE4A250 CRC64;
MARKRGISSL LLIYKQSFVI WGALLIFSPL LMFVGDSHGL QAKCLYCVAV MGSYWVFEAL
PLAITAFIPM ILFPLFGIMR SEEVARAYLP DTCFLFMGGL MVALAVEKCE LHARVALFVL
KTVGSEPARV MAGFMGVTGF LSMWISNTAT TALMVPILQS VITELVSNHR MEDLVALCEA
HHNSSRKHSV GMRRLSLPNE NNEIKREEMD TAMSPREQKM AKGLMLSVCF SANIGGAATI
TGTASNLVLV GQLNELFPGA DTGVNFLSWL IFAFPMVFCC LIYCWCVLYL LYLRDAPKGS
IIVTRKLQQK YNELHAFSFA EMAVIFCFAL LLVLWILREP QVVPGWGEMF KDEFVSDATS
AMFIVILLFT LPEKLPSSRG SSEQRKASSG LLDWATVQDR FPWSVLFLLG GGFALAAGVK
ESGLSHDIGA IMRYLDVFNH NIIMLICIII SVTLTNVCSN TVIASIFIPI VAELARSLEI
DPLNFMLPVT ISASFAFLLP VATPPNAIVF SSGYLKVFDM FVSGLCVTLG CVVLSMLNML
LWAGFVFNLH LFPQWAANPS PPLDVQDWAV ENNITFVGTS KL
