ID   NAD2_CAEEL              Reviewed;         551 AA.
AC   P32739; Q86MC8;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 3.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Sodium-dependent high-affinity dicarboxylate transporter 2;
DE   AltName: Full=Na(+)/dicarboxylate cotransporter 2;
DE            Short=NaDC-2;
DE            Short=ceNaDC2;
GN   Name=nac-2; Synonyms=indy-3, nat-1; ORFNames=R107.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Fei Y.-J., Inoue K., Ganapathy V.;
RT   "A second high-affinity dicarboxylate transporter from C. elegans.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: High-affinity sodium-dicarboxylate cotransporter that accepts
CC       a range of tricarboxylic acid-cycle intermediates with 4-5 carbon
CC       atoms. There is no interaction with monocarboxylates (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC       NADC subfamily. {ECO:0000305}.
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DR   EMBL; AY090486; AAM11895.1; -; mRNA.
DR   EMBL; Z14092; CAA78468.2; -; Genomic_DNA.
DR   PIR; A88546; A88546.
DR   PIR; S30871; S30871.
DR   RefSeq; NP_001254977.1; NM_001268048.1.
DR   AlphaFoldDB; P32739; -.
DR   SMR; P32739; -.
DR   STRING; 6239.R107.1b; -.
DR   PaxDb; P32739; -.
DR   EnsemblMetazoa; R107.1a.1; R107.1a.1; WBGene00003518.
DR   GeneID; 187898; -.
DR   UCSC; R107.1.1; c. elegans.
DR   CTD; 187898; -.
DR   WormBase; R107.1a; CE33536; WBGene00003518; nac-2.
DR   eggNOG; KOG1281; Eukaryota.
DR   GeneTree; ENSGT01030000234550; -.
DR   HOGENOM; CLU_005170_9_2_1; -.
DR   InParanoid; P32739; -.
DR   PhylomeDB; P32739; -.
DR   Reactome; R-CEL-433137; Sodium-coupled sulphate, di- and tri-carboxylate transporters.
DR   PRO; PR:P32739; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00003518; Expressed in embryo and 3 other tissues.
DR   ExpressionAtlas; P32739; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0015137; F:citrate transmembrane transporter activity; IDA:WormBase.
DR   GO; GO:0015141; F:succinate transmembrane transporter activity; IDA:WormBase.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0098656; P:anion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0015746; P:citrate transport; IDA:WormBase.
DR   GO; GO:0008340; P:determination of adult lifespan; IMP:WormBase.
DR   GO; GO:0006629; P:lipid metabolic process; IMP:WormBase.
DR   GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0015744; P:succinate transport; IDA:WormBase.
DR   InterPro; IPR031312; Na/sul_symport_CS.
DR   InterPro; IPR001898; SLC13A/DASS.
DR   Pfam; PF00939; Na_sulph_symp; 1.
DR   PROSITE; PS01271; NA_SULFATE; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Membrane; Reference proteome; Sodium; Sodium transport;
KW   Symport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..551
FT                   /note="Sodium-dependent high-affinity dicarboxylate
FT                   transporter 2"
FT                   /id="PRO_0000172497"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        449..469
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        497..517
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        91
FT                   /note="I -> S (in Ref. 1; AAM11895)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        182
FT                   /note="L -> M (in Ref. 1; AAM11895)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   551 AA;  61000 MW;  4E71C31C84C4B427 CRC64;
     MKPSPQRTLI KKLLVLLGPL VAVPLLFFGP EYRCLFSIIF LSTYWIGEAF PIGVTSLFPL
     ALYPILQIVP SKQISPVYFK DSIVLFMCTL IMAMAVEATG LHRRIALKLL TKVGAKQPVM
     LLGFMCITSF ISFFVSDTAC TALMCPTAVA LLMSMSDAVQ HLKEDHRKPK PPPDDATVAE
     KLRIDDMTPQ DAGFCKALIL ACAHASLIGG TAIITSTGPN LVFRENIHKR YPEGQVTMTY
     LQWMVFAIPP MFVYLLASYI ILVCYFMGPS TFARWFERPS KEEAHLKKLI EKNIQTMYED
     LGDVSWGEKS VFVFFILLIG SWISRDPGFT PGWGDLLPHR NFISDSVSGV LISCILFVWP
     KDPFDPIDPM APILKWTDMK SKFSWSCTLL IGAGYAISEG VDKSGLSRLI SCGMKNIFVG
     MSSLPLQLTV TTIIVIMTEF ASNVSTGSIF IPISLGVAES MGVHPLYLAL PTTVACSFAF
     MLPISTPPNA VVYDTKVISM VEMIVCGFLL NIACILITSL NMNTWTYFIF SLNIFPENIV
     ISSENSSYPV C