ID   NADC_RHORU              Reviewed;         296 AA.
AC   P77938;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Probable nicotinate-nucleotide pyrophosphorylase [carboxylating];
DE            EC=2.4.2.19;
DE   AltName: Full=Quinolinate phosphoribosyltransferase [decarboxylating];
DE            Short=QAPRTase;
GN   Name=nadC;
OS   Rhodospirillum rubrum.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Rhodospirillaceae; Rhodospirillum.
OX   NCBI_TaxID=1085;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=UR1;
RX   PubMed=7721706; DOI=10.1128/jb.177.8.2157-2163.1995;
RA   Shelver D., Kerby R.L., He Y., Roberts G.P.;
RT   "Carbon monoxide-induced activation of gene expression in Rhodospirillum
RT   rubrum requires the product of cooA, a member of the cyclic AMP receptor
RT   protein family of transcriptional regulators.";
RL   J. Bacteriol. 177:2157-2163(1995).
CC   -!- FUNCTION: Involved in the catabolism of quinolinic acid (QA).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=CO2 + diphosphate + nicotinate beta-D-ribonucleotide = 5-
CC         phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate;
CC         Xref=Rhea:RHEA:12733, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:29959, ChEBI:CHEBI:33019, ChEBI:CHEBI:57502,
CC         ChEBI:CHEBI:58017; EC=2.4.2.19;
CC   -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-
CC       ribonucleotide from quinolinate: step 1/1.
CC   -!- SUBUNIT: Hexamer formed by 3 homodimers. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NadC/ModD family. {ECO:0000305}.
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DR   EMBL; U65510; AAC45128.1; -; Genomic_DNA.
DR   PIR; T51326; T51326.
DR   RefSeq; WP_011389186.1; NZ_CP077803.1.
DR   AlphaFoldDB; P77938; -.
DR   SMR; P77938; -.
DR   OMA; DMIMLKD; -.
DR   UniPathway; UPA00253; UER00331.
DR   GO; GO:0004514; F:nicotinate-nucleotide diphosphorylase (carboxylating) activity; IEA:UniProtKB-EC.
DR   GO; GO:0009435; P:NAD biosynthetic process; IMP:CACAO.
DR   CDD; cd01572; QPRTase; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   Gene3D; 3.90.1170.20; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR004393; NadC.
DR   InterPro; IPR027277; NadC/ModD.
DR   InterPro; IPR036068; Nicotinate_pribotase-like_C.
DR   InterPro; IPR037128; Quinolinate_PRibosylTase_N_sf.
DR   InterPro; IPR002638; Quinolinate_PRibosylTrfase_C.
DR   InterPro; IPR022412; Quinolinate_PRibosylTrfase_N.
DR   PANTHER; PTHR32179; PTHR32179; 1.
DR   Pfam; PF01729; QRPTase_C; 1.
DR   Pfam; PF02749; QRPTase_N; 1.
DR   PIRSF; PIRSF006250; NadC_ModD; 1.
DR   SUPFAM; SSF51690; SSF51690; 1.
DR   TIGRFAMs; TIGR00078; nadC; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Pyridine nucleotide biosynthesis; Transferase.
FT   CHAIN           1..296
FT                   /note="Probable nicotinate-nucleotide pyrophosphorylase
FT                   [carboxylating]"
FT                   /id="PRO_0000155948"
FT   BINDING         107
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         140..142
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         164
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         174
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         204
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         226
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         249..251
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         270..272
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   296 AA;  30536 MW;  96605A621C84DCAE CRC64;
     MRPNHPVAAL SPFAIDEAVR RALAEDLGRA GDITSTATIP AATRAHARFV ARQPGILAGL
     GCARSAFALL DDTVTFTTPL EDGAEIAAGQ TVAEVAGAAR TILAAERTAL NFLGHLSGIA
     TRTRRFGDAI AHTRARLTCT RKTTPGLRGL EKYAVRCGGG SNHRFGLDDA VLIKDNHIAV
     AGGVSAALSR ARAGVGHMVR IEIEVDTLEQ LAEVLAVGGA EVVLLDNMDA PTLTRAVDMV
     AGRLVTEASG GVSLDTIAAL AESGVDYISV GALTHSVTTL DIGLDIVVAP PKAERA