NADD_LACLA
ID NADD_LACLA Reviewed; 195 AA.
AC Q9CGJ7;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Probable nicotinate-nucleotide adenylyltransferase;
DE EC=2.7.7.18;
DE AltName: Full=Deamido-NAD(+) diphosphorylase;
DE AltName: Full=Deamido-NAD(+) pyrophosphorylase;
DE AltName: Full=Nicotinate mononucleotide adenylyltransferase;
DE Short=NaMN adenylyltransferase;
GN Name=nadD; OrderedLocusNames=LL1099; ORFNames=L106374;
OS Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=272623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
CC -!- FUNCTION: Catalyzes the reversible adenylation of nicotinate
CC mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+)
CC + diphosphate; Xref=Rhea:RHEA:22860, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57502,
CC ChEBI:CHEBI:58437; EC=2.7.7.18;
CC -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+)
CC from nicotinate D-ribonucleotide: step 1/1.
CC -!- SIMILARITY: Belongs to the NadD family. {ECO:0000305}.
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DR EMBL; AE005176; AAK05197.1; -; Genomic_DNA.
DR PIR; C86762; C86762.
DR RefSeq; NP_267255.1; NC_002662.1.
DR RefSeq; WP_010905755.1; NC_002662.1.
DR AlphaFoldDB; Q9CGJ7; -.
DR SMR; Q9CGJ7; -.
DR STRING; 272623.L106374; -.
DR PaxDb; Q9CGJ7; -.
DR EnsemblBacteria; AAK05197; AAK05197; L106374.
DR KEGG; lla:L106374; -.
DR PATRIC; fig|272623.7.peg.1177; -.
DR eggNOG; COG1057; Bacteria.
DR HOGENOM; CLU_069765_3_1_9; -.
DR OMA; IHIGHLI; -.
DR UniPathway; UPA00253; UER00332.
DR Proteomes; UP000002196; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004515; F:nicotinate-nucleotide adenylyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd02165; NMNAT; 1.
DR Gene3D; 3.40.50.620; -; 1.
DR HAMAP; MF_00244; NaMN_adenylyltr; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR005248; NadD/NMNAT.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR Pfam; PF01467; CTP_transf_like; 1.
DR TIGRFAMs; TIGR00125; cyt_tran_rel; 1.
DR TIGRFAMs; TIGR00482; TIGR00482; 1.
PE 3: Inferred from homology;
KW ATP-binding; NAD; Nucleotide-binding; Nucleotidyltransferase;
KW Pyridine nucleotide biosynthesis; Reference proteome; Transferase.
FT CHAIN 1..195
FT /note="Probable nicotinate-nucleotide adenylyltransferase"
FT /id="PRO_0000181417"
SQ SEQUENCE 195 AA; 22651 MW; C3273F631598B482 CRC64;
MDKGNRKKVG LLGGNFNPIH HAHLMMADQV AQQMNLDKVL LMPENIPPHV DEKETISAKH
RVKMLELAIK ENPRLGLELI EIERGGKSYS YDTLKLLTEA NPDTDYYFII GSDMVEYLPK
WYKIDELLKL VTFIALRRKD TISKSPYPVT WLDAPLLPIS STMLREMFAK NIEPTYFLPQ
NVIDYIKTEK LYKKR