ID   A16_ANOGA               Reviewed;         192 AA.
AC   Q93118; Q7Q2T9;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Protein A16;
DE   Flags: Precursor;
GN   Name=CTL3; ORFNames=AGAP004810;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP   INDUCTION.
RC   STRAIN=G3; TISSUE=Larva;
RX   PubMed=8917545; DOI=10.1073/pnas.93.23.13066;
RA   Dimopoulos G.M., Richman A.M., della Torre A., Kafatos F.C., Louis C.;
RT   "Identification and characterization of differentially expressed cDNAs of
RT   the vector mosquito, Anopheles gambiae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:13066-13071(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- TISSUE SPECIFICITY: Expressed in the gut of adults.
CC       {ECO:0000269|PubMed:8917545}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during embryonic, larval and pupal
CC       stages. Highest expression is seen in late larval stages.
CC       {ECO:0000269|PubMed:8917545}.
CC   -!- INDUCTION: Not induced by bacterial challenge in larvae.
CC       {ECO:0000269|PubMed:8917545}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Y08163; CAA69355.1; -; mRNA.
DR   EMBL; AAAB01008968; EAA13236.4; -; Genomic_DNA.
DR   RefSeq; XP_317999.4; XM_317999.4.
DR   AlphaFoldDB; Q93118; -.
DR   SMR; Q93118; -.
DR   PaxDb; Q93118; -.
DR   GeneID; 1278414; -.
DR   KEGG; aga:AgaP_AGAP004810; -.
DR   CTD; 1278414; -.
DR   VEuPathDB; VectorBase:AGAP004810; -.
DR   HOGENOM; CLU_1416251_0_0_1; -.
DR   InParanoid; Q93118; -.
DR   OrthoDB; 1507306at2759; -.
DR   PhylomeDB; Q93118; -.
DR   Proteomes; UP000007062; Chromosome 2L.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Lectin; Reference proteome; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..192
FT                   /note="Protein A16"
FT                   /id="PRO_0000017555"
FT   DOMAIN          71..186
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        163..177
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ   SEQUENCE   192 AA;  20811 MW;  EFEA2CBD9B0824A0 CRC64;
     MLLANTAAAV LLLIVCIGAS VGLPTVDEEN VVQAEQLPIL PTADSSKPTD DTVKAIAPQP
     RYLLPADFAV KNKKFTIGTL GVGSFFRAWR NCIDEGKGLA TIESEKEQKY LESLLKASST
     GSNYWIGATN IGASNTNKLT WITTDLPVQT KPPFLNVVAK STCIALTPTG SWTLRNCLNP
     LNIFPYICEE YF