NADD_PSEAE
ID NADD_PSEAE Reviewed; 214 AA.
AC Q9HX21;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Probable nicotinate-nucleotide adenylyltransferase;
DE EC=2.7.7.18;
DE AltName: Full=Deamido-NAD(+) diphosphorylase;
DE AltName: Full=Deamido-NAD(+) pyrophosphorylase;
DE AltName: Full=Nicotinate mononucleotide adenylyltransferase;
DE Short=NaMN adenylyltransferase;
GN Name=nadD; OrderedLocusNames=PA4006;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Catalyzes the reversible adenylation of nicotinate
CC mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+)
CC + diphosphate; Xref=Rhea:RHEA:22860, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57502,
CC ChEBI:CHEBI:58437; EC=2.7.7.18;
CC -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+)
CC from nicotinate D-ribonucleotide: step 1/1.
CC -!- SIMILARITY: Belongs to the NadD family. {ECO:0000305}.
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DR EMBL; AE004091; AAG07393.1; -; Genomic_DNA.
DR PIR; B83147; B83147.
DR RefSeq; NP_252695.1; NC_002516.2.
DR RefSeq; WP_003093199.1; NZ_QZGE01000038.1.
DR PDB; 1YUL; X-ray; 2.00 A; A=1-214.
DR PDB; 1YUM; X-ray; 1.70 A; A/B/C/D=1-214.
DR PDB; 1YUN; X-ray; 2.00 A; A/B=1-214.
DR PDBsum; 1YUL; -.
DR PDBsum; 1YUM; -.
DR PDBsum; 1YUN; -.
DR AlphaFoldDB; Q9HX21; -.
DR SMR; Q9HX21; -.
DR STRING; 287.DR97_3861; -.
DR PaxDb; Q9HX21; -.
DR PRIDE; Q9HX21; -.
DR EnsemblBacteria; AAG07393; AAG07393; PA4006.
DR GeneID; 878969; -.
DR KEGG; pae:PA4006; -.
DR PATRIC; fig|208964.12.peg.4198; -.
DR PseudoCAP; PA4006; -.
DR HOGENOM; CLU_069765_0_0_6; -.
DR InParanoid; Q9HX21; -.
DR OMA; IHIGHLI; -.
DR PhylomeDB; Q9HX21; -.
DR BioCyc; PAER208964:G1FZ6-4079-MON; -.
DR BRENDA; 2.7.7.18; 5087.
DR UniPathway; UPA00253; UER00332.
DR EvolutionaryTrace; Q9HX21; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000309; F:nicotinamide-nucleotide adenylyltransferase activity; IBA:GO_Central.
DR GO; GO:0004515; F:nicotinate-nucleotide adenylyltransferase activity; IBA:GO_Central.
DR GO; GO:0009435; P:NAD biosynthetic process; IBA:GO_Central.
DR CDD; cd02165; NMNAT; 1.
DR Gene3D; 3.40.50.620; -; 1.
DR HAMAP; MF_00244; NaMN_adenylyltr; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR005248; NadD/NMNAT.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR Pfam; PF01467; CTP_transf_like; 1.
DR TIGRFAMs; TIGR00125; cyt_tran_rel; 1.
DR TIGRFAMs; TIGR00482; TIGR00482; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; NAD; Nucleotide-binding; Nucleotidyltransferase;
KW Pyridine nucleotide biosynthesis; Reference proteome; Transferase.
FT CHAIN 1..214
FT /note="Probable nicotinate-nucleotide adenylyltransferase"
FT /id="PRO_0000181432"
FT STRAND 4..10
FT /evidence="ECO:0007829|PDB:1YUM"
FT HELIX 17..30
FT /evidence="ECO:0007829|PDB:1YUM"
FT STRAND 33..39
FT /evidence="ECO:0007829|PDB:1YUM"
FT HELIX 44..46
FT /evidence="ECO:0007829|PDB:1YUM"
FT HELIX 53..64
FT /evidence="ECO:0007829|PDB:1YUM"
FT STRAND 70..72
FT /evidence="ECO:0007829|PDB:1YUM"
FT HELIX 75..78
FT /evidence="ECO:0007829|PDB:1YUM"
FT STRAND 79..82
FT /evidence="ECO:0007829|PDB:1YUM"
FT HELIX 85..95
FT /evidence="ECO:0007829|PDB:1YUM"
FT STRAND 101..107
FT /evidence="ECO:0007829|PDB:1YUM"
FT HELIX 108..111
FT /evidence="ECO:0007829|PDB:1YUM"
FT HELIX 112..116
FT /evidence="ECO:0007829|PDB:1YUM"
FT HELIX 120..122
FT /evidence="ECO:0007829|PDB:1YUM"
FT TURN 124..126
FT /evidence="ECO:0007829|PDB:1YUM"
FT STRAND 128..133
FT /evidence="ECO:0007829|PDB:1YUM"
FT STRAND 135..137
FT /evidence="ECO:0007829|PDB:1YUM"
FT HELIX 143..145
FT /evidence="ECO:0007829|PDB:1YUM"
FT HELIX 146..152
FT /evidence="ECO:0007829|PDB:1YUM"
FT HELIX 157..159
FT /evidence="ECO:0007829|PDB:1YUM"
FT STRAND 162..164
FT /evidence="ECO:0007829|PDB:1YUM"
FT STRAND 167..171
FT /evidence="ECO:0007829|PDB:1YUM"
FT HELIX 179..187
FT /evidence="ECO:0007829|PDB:1YUM"
FT HELIX 198..206
FT /evidence="ECO:0007829|PDB:1YUM"
FT TURN 207..210
FT /evidence="ECO:0007829|PDB:1YUM"
SQ SEQUENCE 214 AA; 23801 MW; 95FF8237AD0C3A69 CRC64;
MGKRIGLFGG TFDPVHIGHM RSAVEMAEQF ALDELRLLPN ARPPHRETPQ VSAAQRLAMV
ERAVAGVERL TVDPRELQRD KPSYTIDTLE SVRAELAADD QLFMLIGWDA FCGLPTWHRW
EALLDHCHIV VLQRPDADSE PPESLRDLLA ARSVADPQAL KGPGGQITFV WQTPLAVSAT
QIRALLGAGR SVRFLVPDAV LNYIEAHHLY RAPH
