AROC_CARRP
ID AROC_CARRP Reviewed; 345 AA.
AC Q05FR1;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Chorismate synthase;
DE EC=4.2.3.5;
DE AltName: Full=5-enolpyruvylshikimate-3-phosphate phospholyase;
GN Name=aroC; OrderedLocusNames=CRP_079;
OS Carsonella ruddii (strain PV).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Zymobacter group; Candidatus Carsonella.
OX NCBI_TaxID=387662;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PV;
RX PubMed=17038615; DOI=10.1126/science.1134196;
RA Nakabachi A., Yamashita A., Toh H., Ishikawa H., Dunbar H.E., Moran N.A.,
RA Hattori M.;
RT "The 160-kilobase genome of the bacterial endosymbiont Carsonella.";
RL Science 314:267-267(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate +
CC phosphate; Xref=Rhea:RHEA:21020, ChEBI:CHEBI:29748,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57701; EC=4.2.3.5;
CC -!- COFACTOR:
CC Name=FMNH2; Xref=ChEBI:CHEBI:57618; Evidence={ECO:0000250};
CC -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC 7/7.
CC -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the chorismate synthase family. {ECO:0000305}.
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DR EMBL; AP009180; BAF35110.1; -; Genomic_DNA.
DR AlphaFoldDB; Q05FR1; -.
DR SMR; Q05FR1; -.
DR STRING; 387662.CRP_079; -.
DR EnsemblBacteria; BAF35110; BAF35110; CRP_079.
DR KEGG; crp:CRP_079; -.
DR HOGENOM; CLU_034547_0_2_6; -.
DR OMA; MLSINAV; -.
DR UniPathway; UPA00053; UER00090.
DR Proteomes; UP000000777; Chromosome.
DR GO; GO:0004107; F:chorismate synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd07304; Chorismate_synthase; 1.
DR Gene3D; 3.60.150.10; -; 1.
DR InterPro; IPR000453; Chorismate_synth.
DR InterPro; IPR035904; Chorismate_synth_AroC_sf.
DR InterPro; IPR020541; Chorismate_synthase_CS.
DR PANTHER; PTHR21085; PTHR21085; 1.
DR Pfam; PF01264; Chorismate_synt; 1.
DR PIRSF; PIRSF001456; Chorismate_synth; 1.
DR SUPFAM; SSF103263; SSF103263; 1.
DR TIGRFAMs; TIGR00033; aroC; 1.
DR PROSITE; PS00789; CHORISMATE_SYNTHASE_3; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Lyase;
KW Reference proteome.
FT CHAIN 1..345
FT /note="Chorismate synthase"
FT /id="PRO_0000405966"
SQ SEQUENCE 345 AA; 39214 MW; 174716CC40593BD7 CRC64;
MNNSYGEIIK ISTFGESHGL IIGALIDGFF SNLYISEKFI QKNLNLRKPF TSLFSTQRRE
QDKVKIFTGI FKNKTTGAPV LMLIKNNDKQ SSDYNNISLN FRPGHADYTY FLKYKFRDYR
GGGRSSARET ACRVASGCVF KNLIYNKGVI VRSYIKKIGF LKINFKYWNY TLNRFFSNLL
FINEIKDIIN NCKNSCNSLS SEIVIIINGL EPSLGDPLYK KINSTISNYL LSINATKSIC
FGFNFKNKNS FQVKDEIKNS GFTSNNNGGI LAGITNGQPL VIKILFKPTS STSRKIKTIN
EKLKNITNKT YGRHDPCVGL RAVPVIESML YTILINKILK KKIYE