ID   NADHK_ORYSJ             Reviewed;         325 AA.
AC   Q6EQG2; Q0J2G4;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Probable NADH kinase;
DE            EC=2.7.1.86;
GN   OrderedLocusNames=Os09g0345700, LOC_Os09g17680; ORFNames=OSJNBb0085I16.26;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: Key source of the cellular reductant NADPH which is an
CC       important antioxidant factor. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + NADH = ADP + H(+) + NADPH; Xref=Rhea:RHEA:12260,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:456216; EC=2.7.1.86;
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NAD kinase family. {ECO:0000305}.
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DR   EMBL; AP005700; BAD29108.1; -; Genomic_DNA.
DR   EMBL; AP008215; BAF24851.1; -; Genomic_DNA.
DR   EMBL; AP014965; BAT07607.1; -; Genomic_DNA.
DR   EMBL; AK073719; BAG93606.1; -; mRNA.
DR   RefSeq; XP_015651403.1; XM_015795917.1.
DR   AlphaFoldDB; Q6EQG2; -.
DR   SMR; Q6EQG2; -.
DR   STRING; 4530.OS09T0345700-01; -.
DR   PaxDb; Q6EQG2; -.
DR   PRIDE; Q6EQG2; -.
DR   EnsemblPlants; Os09t0345700-01; Os09t0345700-01; Os09g0345700.
DR   GeneID; 4346801; -.
DR   Gramene; Os09t0345700-01; Os09t0345700-01; Os09g0345700.
DR   KEGG; osa:4346801; -.
DR   eggNOG; KOG4180; Eukaryota.
DR   HOGENOM; CLU_067437_0_0_1; -.
DR   InParanoid; Q6EQG2; -.
DR   OMA; MIYIDGS; -.
DR   OrthoDB; 1416565at2759; -.
DR   Proteomes; UP000000763; Chromosome 9.
DR   Proteomes; UP000059680; Chromosome 9.
DR   Genevisible; Q6EQG2; OS.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003951; F:NAD+ kinase activity; IBA:GO_Central.
DR   GO; GO:0042736; F:NADH kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019674; P:NAD metabolic process; IEA:InterPro.
DR   GO; GO:0006741; P:NADP biosynthetic process; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.200.30; -; 1.
DR   Gene3D; 3.40.50.10330; -; 1.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR017437; ATP-NAD_kinase_PpnK-typ_C.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   InterPro; IPR002504; NADK.
DR   Pfam; PF01513; NAD_kinase; 1.
DR   SUPFAM; SSF111331; SSF111331; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Kinase; NAD; NADP; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..325
FT                   /note="Probable NADH kinase"
FT                   /id="PRO_0000233701"
SQ   SEQUENCE   325 AA;  35517 MW;  D4A17F7204735D4B CRC64;
     MALRRVLLFV KPFDVYPPRP LAAAASSPPP PPPPLRVSNP KVLNYLDDRC RVHKETINLC
     KSVLQRKSID WISVQRNDMS NPIHDVDLVI SVGGDGTLLR ASHFLNSSIP VLGVNSDPTC
     PDEVDELTDE FDARRSTGHL CAATAANFEQ ILDATLDGSR QPSELSRISV KLNGLQLPTY
     ALNDILVSHP CPASVSRFSF RKRSNTGESS HLINCRSSGL RVATPAGSTA AMLSAGGFVM
     PISSHELQYM IREPISPRDA DKPLLHGLVK QGQHILVVWY NEEGAVYFDG SHVMHSIQHG
     DTLEISSDAP ILKVILPENL LKQGS