ID   NADM_AERPE              Reviewed;         172 AA.
AC   Q9YER8;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Nicotinamide-nucleotide adenylyltransferase;
DE            EC=2.7.7.1;
DE   AltName: Full=NAD(+) diphosphorylase;
DE   AltName: Full=NAD(+) pyrophosphorylase;
DE   AltName: Full=NMN adenylyltransferase;
GN   OrderedLocusNames=APE_0513.1;
OS   Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS   K1).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX   PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA   Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA   Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT   Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate
CC         + NAD(+); Xref=Rhea:RHEA:21360, ChEBI:CHEBI:14649, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57540; EC=2.7.7.1;
CC   -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from
CC       nicotinamide D-ribonucleotide: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the archaeal NMN adenylyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; BA000002; BAA79478.2; -; Genomic_DNA.
DR   PIR; B72748; B72748.
DR   AlphaFoldDB; Q9YER8; -.
DR   SMR; Q9YER8; -.
DR   STRING; 272557.APE_0513.1; -.
DR   EnsemblBacteria; BAA79478; BAA79478; APE_0513.1.
DR   KEGG; ape:APE_0513.1; -.
DR   eggNOG; arCOG00972; Archaea.
DR   OMA; NSVWVSH; -.
DR   UniPathway; UPA00253; UER00600.
DR   Proteomes; UP000002518; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000309; F:nicotinamide-nucleotide adenylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd02166; NMNAT_Archaea; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_00243; NMN_adenylyltr; 1.
DR   InterPro; IPR004821; Cyt_trans-like.
DR   InterPro; IPR006418; NMN_Atrans_arc.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   Pfam; PF01467; CTP_transf_like; 1.
DR   TIGRFAMs; TIGR00125; cyt_tran_rel; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; NAD; Nucleotide-binding; Nucleotidyltransferase;
KW   Pyridine nucleotide biosynthesis; Reference proteome; Transferase.
FT   CHAIN           1..172
FT                   /note="Nicotinamide-nucleotide adenylyltransferase"
FT                   /id="PRO_0000134987"
SQ   SEQUENCE   172 AA;  19828 MW;  E100C434A2064E4A CRC64;
     MKRLLVVGRF QPPHLGHLHT IKWALGRAEE VIVVVGSAQE SYTLENPMTA GERVHALRLM
     LEELDDWCRR LMIAPVPDIA MNKVWVQYLK MLLPPFDGVV SGNELVLMLF EDMGLAALRP
     PMFRRGECSG TRIRRLMASG ESGWEDCLHP QVRRYVEEIG LPERLRRLQE MR