ID   NADM_SACS2              Reviewed;         172 AA.
AC   P57084;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2001, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Nicotinamide-nucleotide adenylyltransferase;
DE            EC=2.7.7.1;
DE   AltName: Full=NAD(+) diphosphorylase;
DE   AltName: Full=NAD(+) pyrophosphorylase;
DE   AltName: Full=NMN adenylyltransferase;
GN   OrderedLocusNames=SSO0255;
OS   Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS   (Sulfolobus solfataricus).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Saccharolobus.
OX   NCBI_TaxID=273057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=11427726; DOI=10.1073/pnas.141222098;
RA   She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA   Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA   Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA   Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA   Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA   Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT   "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-33, AND CHARACTERIZATION.
RC   STRAIN=DSM 5833 / MT-4;
RX   PubMed=9401030; DOI=10.1128/jb.179.24.7718-7723.1997;
RA   Raffaelli N., Pisani F.M., Lorenzi T., Emanuelli M., Amici A., Ruggieri S.,
RA   Magni G.;
RT   "Characterization of nicotinamide mononucleotide adenylyltransferase from
RT   thermophilic archaea.";
RL   J. Bacteriol. 179:7718-7723(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate
CC         + NAD(+); Xref=Rhea:RHEA:21360, ChEBI:CHEBI:14649, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57540; EC=2.7.7.1;
CC   -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from
CC       nicotinamide D-ribonucleotide: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the archaeal NMN adenylyltransferase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK40594.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE006641; AAK40594.1; ALT_INIT; Genomic_DNA.
DR   PIR; C90167; C90167.
DR   RefSeq; WP_014511516.1; NC_002754.1.
DR   AlphaFoldDB; P57084; -.
DR   SMR; P57084; -.
DR   STRING; 273057.SSO0255; -.
DR   EnsemblBacteria; AAK40594; AAK40594; SSO0255.
DR   GeneID; 44129224; -.
DR   KEGG; sso:SSO0255; -.
DR   PATRIC; fig|273057.12.peg.249; -.
DR   eggNOG; arCOG00972; Archaea.
DR   HOGENOM; CLU_108783_0_0_2; -.
DR   InParanoid; P57084; -.
DR   OMA; NSVWVSH; -.
DR   PhylomeDB; P57084; -.
DR   BioCyc; MetaCyc:MON-12229; -.
DR   BRENDA; 2.7.7.1; 6163.
DR   UniPathway; UPA00253; UER00600.
DR   Proteomes; UP000001974; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000309; F:nicotinamide-nucleotide adenylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd02166; NMNAT_Archaea; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_00243; NMN_adenylyltr; 1.
DR   InterPro; IPR004821; Cyt_trans-like.
DR   InterPro; IPR006418; NMN_Atrans_arc.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   Pfam; PF01467; CTP_transf_like; 1.
DR   TIGRFAMs; TIGR01527; arch_NMN_Atrans; 1.
DR   TIGRFAMs; TIGR00125; cyt_tran_rel; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Cytoplasm; Direct protein sequencing; NAD; Nucleotide-binding;
KW   Nucleotidyltransferase; Pyridine nucleotide biosynthesis;
KW   Reference proteome; Transferase.
FT   CHAIN           1..172
FT                   /note="Nicotinamide-nucleotide adenylyltransferase"
FT                   /id="PRO_0000135005"
FT   CONFLICT        2
FT                   /note="Missing (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        23..24
FT                   /note="WS -> IK (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        30..31
FT                   /note="EL -> PP (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   172 AA;  20096 MW;  03A4304EA0C09582 CRC64;
     MSRGLYPGRF QPFHLGHLNV IKWSLERVDE LIILVGSSQE SHTVTNPFTA GERVEMIRNS
     LKDVGMDLSR IYIIPMPDIL MNNIWAHYVS TYTPKFEVVF ARNPLVVRIF KEAGYKVEIP
     PAFNREKYNS TYIRRLIILN DNWSELVPKP VYKYILEIKG DQRLREIVGT DK