ID   NAGC_ECO57              Reviewed;         406 AA.
AC   P0AF22; P15301;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=N-acetylglucosamine repressor;
GN   Name=nagC; OrderedLocusNames=Z0823, ECs0706;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Acts as a repressor of the nagEBACD operon and acts both as
CC       an activator and a repressor for the transcription of the glmSU operon.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG54998.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34129.1; -; Genomic_DNA.
DR   PIR; B85567; B85567.
DR   PIR; B90717; B90717.
DR   RefSeq; NP_308733.1; NC_002695.1.
DR   RefSeq; WP_000187594.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AF22; -.
DR   SMR; P0AF22; -.
DR   STRING; 155864.EDL933_0744; -.
DR   EnsemblBacteria; AAG54998; AAG54998; Z0823.
DR   EnsemblBacteria; BAB34129; BAB34129; ECs_0706.
DR   GeneID; 66671054; -.
DR   GeneID; 917075; -.
DR   KEGG; ece:Z0823; -.
DR   KEGG; ecs:ECs_0706; -.
DR   PATRIC; fig|386585.9.peg.818; -.
DR   eggNOG; COG1846; Bacteria.
DR   eggNOG; COG1940; Bacteria.
DR   HOGENOM; CLU_036604_13_1_6; -.
DR   OMA; VDFGHTH; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR000600; ROK.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR18964; PTHR18964; 1.
DR   Pfam; PF01047; MarR; 1.
DR   Pfam; PF00480; ROK; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF53067; SSF53067; 1.
DR   PROSITE; PS01125; ROK; 1.
PE   3: Inferred from homology;
KW   Activator; Carbohydrate metabolism; DNA-binding; Reference proteome;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..406
FT                   /note="N-acetylglucosamine repressor"
FT                   /id="PRO_0000095692"
FT   DNA_BIND        35..44
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   406 AA;  44541 MW;  28C4C85D736627C8 CRC64;
     MTPGGQAQIG NVDLVKQLNS AAVYRLIDQY GPISRIQIAE QSQLAPASVT KITRQLIERG
     LIKEVDQQAS TGGRRAISIV TETRNFHAIG VRLGRHDATI TLFDLSSKVL AEEHYPLPER
     TQQTLEHALL NAIAQFIDSY QRKLRELIAI SVILPGLVDP DSGKIHYMPH IQVENWGLVE
     ALEERFKVTC FVGHDIRSLA LAEHYFGASQ DCEDSILVRV HRGTGAGIIS NGRIFIGRNG
     NVGEIGHIQV EPLGERCHCG NFGCLETIAA NAAIEQRVLN LLKQGYQSRV PLDDCTIKTI
     CKAANKGDSL ASEVIEYVGR HLGKTIAIAI NLFNPQKIVI AGEITEADKV LLPAIESCIN
     TQALKAFRTN LPVVRSELDH RSAIGAFALV KRAMLNGILL QHLLEN