ID   NAGD_STAHJ              Reviewed;         263 AA.
AC   Q4L4U2;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Acid sugar phosphatase {ECO:0000250|UniProtKB:Q99VE8};
DE            EC=3.1.3.- {ECO:0000250|UniProtKB:Q99VE8};
GN   Name=nagD; OrderedLocusNames=SH2024;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- FUNCTION: Catalyzes the dephosphorylation of 2-6 carbon acid sugars in
CC       vitro. {ECO:0000250|UniProtKB:Q99VE8}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000250|UniProtKB:Q99VE8};
CC   -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily. NagD family.
CC       {ECO:0000305}.
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DR   EMBL; AP006716; BAE05333.1; -; Genomic_DNA.
DR   RefSeq; WP_011276290.1; NC_007168.1.
DR   AlphaFoldDB; Q4L4U2; -.
DR   SMR; Q4L4U2; -.
DR   STRING; 279808.SH2024; -.
DR   EnsemblBacteria; BAE05333; BAE05333; SH2024.
DR   KEGG; sha:SH2024; -.
DR   eggNOG; COG0647; Bacteria.
DR   HOGENOM; CLU_043473_1_1_9; -.
DR   OMA; PPMHRET; -.
DR   OrthoDB; 1308416at2; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1000; -; 2.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006357; HAD-SF_hydro_IIA.
DR   InterPro; IPR006354; HAD-SF_hydro_IIA_hyp1.
DR   InterPro; IPR023214; HAD_sf.
DR   Pfam; PF13344; Hydrolase_6; 1.
DR   PIRSF; PIRSF000915; PGP-type_phosphatase; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR01460; HAD-SF-IIA; 1.
DR   TIGRFAMs; TIGR01457; HAD-SF-IIA-hyp2; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Magnesium; Metal-binding.
FT   CHAIN           1..263
FT                   /note="Acid sugar phosphatase"
FT                   /id="PRO_0000271491"
SQ   SEQUENCE   263 AA;  28678 MW;  BA23DA2B4209CFED CRC64;
     MKNYKGYLID LDGTMYLGTD EIDGAAQFID YLNNHQIPHL YVTNNSTKTP EEVTQKLKEM
     NIDAKPEEVV TSALATANYI SDEKSDATVY MLGGNGLRTA LTEAGLTVKD DENVDYVAIG
     LDENVTYEKL AVATLAVRKG ARFISTNPDV SIPKERGFLP GNGAITSVVS VSTGQAPQFI
     GKPEPVIMDI ALDILKLDKS DVAMVGDLYD TDIMSGINVG VDTIHVQTGV TTYEELKEKD
     QQPTYSFKDL NVAISELEKN AQK