ID   NAGK_MESAU              Reviewed;          61 AA.
AC   P86200;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 1.
DT   03-AUG-2022, entry version 19.
DE   RecName: Full=N-acetyl-D-glucosamine kinase {ECO:0000250|UniProtKB:Q9QZ08};
DE            Short=N-acetylglucosamine kinase {ECO:0000250|UniProtKB:Q9QZ08};
DE            EC=2.7.1.59;
DE   AltName: Full=GlcNAc kinase {ECO:0000250|UniProtKB:Q9QZ08};
DE   Flags: Fragments;
GN   Name=NAGK {ECO:0000250|UniProtKB:Q9QZ08};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=20400973; DOI=10.1038/aja.2010.19;
RA   Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.;
RT   "Glucose-regulated protein precursor (GRP78) and tumor rejection antigen
RT   (GP96) are unique to hamster caput epididymal spermatozoa.";
RL   Asian J. Androl. 12:344-355(2010).
CC   -!- FUNCTION: Converts endogenous N-acetylglucosamine (GlcNAc), a major
CC       component of complex carbohydrates, from lysosomal degradation or
CC       nutritional sources into GlcNAc 6-phosphate. Involved in the N-
CC       glycolylneuraminic acid (Neu5Gc) degradation pathway. Also has ManNAc
CC       kinase activity (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-D-
CC         glucosamine 6-phosphate; Xref=Rhea:RHEA:17417, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:57513, ChEBI:CHEBI:456216,
CC         ChEBI:CHEBI:506227; EC=2.7.1.59;
CC         Evidence={ECO:0000250|UniProtKB:Q9QZ08};
CC   -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9UJ70}.
CC   -!- SIMILARITY: Belongs to the eukaryotic-type N-acetylglucosamine kinase
CC       family. {ECO:0000255}.
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DR   AlphaFoldDB; P86200; -.
DR   UniPathway; UPA00629; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0045127; F:N-acetylglucosamine kinase activity; ISS:UniProtKB.
DR   GO; GO:0019262; P:N-acetylneuraminate catabolic process; IEA:UniProtKB-UniPathway.
PE   1: Evidence at protein level;
KW   ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Transferase.
FT   CHAIN           <1..>61
FT                   /note="N-acetyl-D-glucosamine kinase"
FT                   /id="PRO_0000394398"
FT   BINDING         45
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UJ70"
FT   MOD_RES         30
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UJ70"
FT   NON_CONS        10..11
FT                   /evidence="ECO:0000305"
FT   NON_CONS        31..32
FT                   /evidence="ECO:0000305"
FT   NON_CONS        44..45
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         61
SQ   SEQUENCE   61 AA;  6868 MW;  F24D4EE847EBDF63 CRC64;
     AGVDPLVPLR QAMFNYFQVP DRLGILTHLY RIAEGAQQGD PLSRSWELLK EGFLLALTQG
     R