ID   NAGR_RALSP              Reviewed;         301 AA.
AC   Q9EXL7;
DT   06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=HTH-type transcriptional activator NagR;
GN   Name=nagR {ECO:0000312|EMBL:AAG13636.1};
OS   Ralstonia sp.
OG   Plasmid pWWU2 {ECO:0000312|EMBL:AAG13636.1}.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=54061;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAG13636.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=U2 {ECO:0000312|EMBL:AAG13636.1};
RX   PubMed=11133965; DOI=10.1128/jb.183.2.700-708.2001;
RA   Zhou N.Y., Fuenmayor S.L., Williams P.A.;
RT   "nag genes of Ralstonia (formerly Pseudomonas) sp. strain U2 encoding
RT   enzymes for gentisate catabolism.";
RL   J. Bacteriol. 183:700-708(2001).
CC   -!- FUNCTION: May regulate the expression of the naphthalene (nagA-F) and
CC       salicylate (nagG-M) metabolism genes. {ECO:0000269|PubMed:11133965}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AF036940; AAG13636.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9EXL7; -.
DR   SMR; Q9EXL7; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Aromatic hydrocarbons catabolism; DNA-binding; Plasmid;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..301
FT                   /note="HTH-type transcriptional activator NagR"
FT                   /id="PRO_0000421809"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   301 AA;  33828 MW;  32497FF37E7F56C2 CRC64;
     MDLRDIDLNL LVVFNQLLLD RSVSTAGEKL GLTQPAVSNS LKRLRAALKD DLFLRTSKGM
     EPTPYALHLA EPVIYALNTL QTALTTRDSF DPFASTRTFN LAMTDIGEMY FMPPLMEALA
     QRAPHIQIST LRPNAGNLKE DMESGAVDLA LGLLPELQTG FFQRRLFRHR YVCMFRKDHP
     SAKSPMSLKQ FSELEHVGVV ALNTGHGEVD GLLERAGIKR RMRLVVPHFI AIGPILHSTD
     LIATVPQRFA VRCEVPFGLT TSPHPAKLPD IAINLFWHAK YNRDPGNMWL RQLFVELFSE
     A