ID   NAH1_ZYGRO              Reviewed;         791 AA.
AC   Q99173;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Na(+)/H(+) antiporter 1;
GN   Name=SOD2;
OS   Zygosaccharomyces rouxii (Candida mogii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX   NCBI_TaxID=4956;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 42981 / IAM 12879 / JCM 22060 / S-96;
RX   PubMed=7483847; DOI=10.1002/yea.320110905;
RA   Watanabe Y., Miwa S., Tamai Y.;
RT   "Characterization of Na+/H(+)-antiporter gene closely related to the salt-
RT   tolerance of yeast Zygosaccharomyces rouxii.";
RL   Yeast 11:829-838(1995).
CC   -!- FUNCTION: Sodium export from cell, takes up external protons in
CC       exchange for internal sodium ions.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the fungal Na(+)/H(+) exchanger family.
CC       {ECO:0000305}.
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DR   EMBL; D43629; BAA07739.1; -; Genomic_DNA.
DR   PIR; S57350; S57350.
DR   AlphaFoldDB; Q99173; -.
DR   SMR; Q99173; -.
DR   STRING; 4956.XP_002497045.1; -.
DR   PRIDE; Q99173; -.
DR   eggNOG; KOG4505; Eukaryota.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0030004; P:cellular monovalent inorganic cation homeostasis; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR013928; Cation/H_antiporter_C.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR004712; Na+/H+_antiporter_fungi.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR032516; Nha1.
DR   PANTHER; PTHR31382:SF4; PTHR31382:SF4; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF08619; Nha1_C; 1.
DR   TIGRFAMs; TIGR00844; c_cpa1; 1.
PE   3: Inferred from homology;
KW   Antiport; Glycoprotein; Ion transport; Membrane; Sodium; Sodium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..791
FT                   /note="Na(+)/H(+) antiporter 1"
FT                   /id="PRO_0000052408"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        319..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          670..694
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          729..791
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        670..691
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        732..746
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        747..762
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        763..779
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        291
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        545
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        572
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        754
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   791 AA;  88623 MW;  5878051C10159173 CRC64;
     MVWRQLEVTK AHVAYSCLGI FSSIFSLVSL FVKERLYIGE SMVASVFGLI VGPHCLNWFN
     PLSWGNTDSI TLEISRILLC LQVFAVSVEL PRKYMQKHWL SVTMLLVPVM TSGWLVIALF
     VWILVPGLNF PASLLMGACI TATDPVLAQS VVSGTFAQKV PGHLRNLLSC ESGCNDGLAF
     PFVFLSIDLL LYPGRGGEIV KDWICVTILW ECIFGSILGC IIGYCGRKAI RFAEGKRIID
     RESFLAFYLI LALTCAGFGS MLGVDDLLVS FFAGTAFAWD GWFATKTHES NVSNVIDVLL
     NYAYFVYLGS ILPWKDFNNA DIGLDVWRLI ILSLVVIFLR RIPAVLLLKP LIPDIKSWRE
     AMFIGHFGPI GVGAVYAAIM SKSQLESHLT DEETPLNYTP GKGSKHWQAM ACLWPITCFS
     IITSVIVHGS SVAVIMLGRY LNTVTLTAAP TSRTASTSTK NSWLQSLPPF DKSGRPFSLQ
     RLDKETSPTP GQIDVRTSGM IAAPALGMRQ RWRQKLHGNK ETESDIEMSD LQRQREEHTG
     TIDLNDTTTE TLGTTNARTP GLAQRSKVNI MNRTETVNTI YGLDKLADDT ENHDVYHVET
     SRVHDIGSSH DDVYTYEFDA DSIDSLERER IKLLREPEQQ AYIAYTEDNQ VIIENRQGEI
     LEYARSHNDG VRDAEAGSHN QGRHKRASSP PLERLRQITN EACKTKYYAY KVGNDLIVED
     ESGEEFRRYR ISPHGGKRKI KKKKINNPVP ERKNHSLLHS EDEMADDEAE SEEENYGDSD
     DLALFVKDHA D