ID   NAH2_METJA              Reviewed;         422 AA.
AC   Q58916;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Probable Na(+)/H(+) antiporter 2;
DE   AltName: Full=MjNhaP2;
GN   OrderedLocusNames=MJ1521;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [2]
RP   SIMILARITY TO NA(+)/H(+) ANTIPORTERS.
RX   PubMed=12220668; DOI=10.1016/s0014-5793(02)03244-1;
RA   Hellmer J., Paetzold R., Zeilinger C.;
RT   "Identification of a pH regulated Na(+)/H(+) antiporter of Methanococcus
RT   jannaschii.";
RL   FEBS Lett. 527:245-249(2002).
CC   -!- FUNCTION: This is probably a Na(+)/H(+) antiporter.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000305}.
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DR   EMBL; L77117; AAB99540.1; -; Genomic_DNA.
DR   PIR; H64489; H64489.
DR   RefSeq; WP_010871045.1; NC_000909.1.
DR   AlphaFoldDB; Q58916; -.
DR   SMR; Q58916; -.
DR   STRING; 243232.MJ_1521; -.
DR   EnsemblBacteria; AAB99540; AAB99540; MJ_1521.
DR   GeneID; 1452429; -.
DR   KEGG; mja:MJ_1521; -.
DR   eggNOG; arCOG01961; Archaea.
DR   HOGENOM; CLU_005912_9_3_2; -.
DR   InParanoid; Q58916; -.
DR   OMA; WFDEYGE; -.
DR   OrthoDB; 47913at2157; -.
DR   PhylomeDB; Q58916; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW   Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..422
FT                   /note="Probable Na(+)/H(+) antiporter 2"
FT                   /id="PRO_0000052403"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        384..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   422 AA;  45810 MW;  AF56570C0626D339 CRC64;
     MNIVLFLGYL SILFAGGAII AKIAKKIGIP DIPLLLIFGL ILSILNVIPK NIVESSFDFI
     GNFGLIILLF IGSFEMEWNI MKRVLDVIIK LDILALLIVW IISGIVFNFV FHLPILSLIG
     LLFGAIVSAT DPATLIPIFS SMDIDPEVAI TLEAESVFND PLGIVVTLIC LSALGLAKAE
     NPILEFFSLA VGGIILGVIA GKFYEIIISK IKFEDYIAPF TLGLAIAFWY FAEGIFPSIT
     GYEISGFMAV AIMGLYIGNV IVHKKEHKKD MEKVAVFMDE LSIFIRILIF VLLGASISIP
     LLEKYALPAF LCALGSILLA RPVGVLIATA IPPIRPLTER IYLALEGPRG VVPATLAAMV
     YTEIMKHPNI VPKNIASLMP PTELAGTILV ATFMTIIVSV VLEASWAKPL ANILLKRKTS
     TS