NAH2_SCHPO
ID NAH2_SCHPO Reviewed; 759 AA.
AC O14123;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Probable Na(+)/H(+) antiporter C3A11.09;
GN Name=sod22; ORFNames=SPAC3A11.09;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-442; SER-446; THR-448 AND
RP SER-735, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Sodium export from cell, takes up external protons in
CC exchange for internal sodium ions. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the fungal Na(+)/H(+) exchanger family.
CC {ECO:0000305}.
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DR EMBL; CU329670; CAB16384.1; -; Genomic_DNA.
DR PIR; T11631; T11631.
DR RefSeq; NP_594194.1; NM_001019618.2.
DR AlphaFoldDB; O14123; -.
DR SMR; O14123; -.
DR BioGRID; 278967; 3.
DR STRING; 4896.SPAC3A11.09.1; -.
DR TCDB; 2.A.36.4.5; the monovalent cation:proton antiporter-1 (cpa1) family.
DR iPTMnet; O14123; -.
DR PaxDb; O14123; -.
DR PRIDE; O14123; -.
DR EnsemblFungi; SPAC3A11.09.1; SPAC3A11.09.1:pep; SPAC3A11.09.
DR GeneID; 2542509; -.
DR KEGG; spo:SPAC3A11.09; -.
DR PomBase; SPAC3A11.09; sod22.
DR VEuPathDB; FungiDB:SPAC3A11.09; -.
DR eggNOG; KOG4505; Eukaryota.
DR HOGENOM; CLU_008635_0_1_1; -.
DR InParanoid; O14123; -.
DR OMA; INWREAL; -.
DR PhylomeDB; O14123; -.
DR PRO; PR:O14123; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:PomBase.
DR GO; GO:0015385; F:sodium:proton antiporter activity; ISO:PomBase.
DR GO; GO:0030007; P:cellular potassium ion homeostasis; IBA:GO_Central.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IC:PomBase.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR004712; Na+/H+_antiporter_fungi.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR31382:SF4; PTHR31382:SF4; 2.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 1: Evidence at protein level;
KW Antiport; Glycoprotein; Ion transport; Membrane; Phosphoprotein;
KW Reference proteome; Sodium; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..759
FT /note="Probable Na(+)/H(+) antiporter C3A11.09"
FT /id="PRO_0000052406"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 514..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..551
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 442
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 446
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 448
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 735
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT CARBOHYD 699
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 713
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 759 AA; 85487 MW; 0C0FD7D62926C298 CRC64;
MAWSQVEISK PHLAYAIIGG FTSLFMLCSL IIKEKLFLGE ATMATATGLI FGPYVAKLFV
PTSWGNTDYI TEELARVLLV VEVFAAGAEL PRAYMLRHWR SMFVMLLPVM IFGWLVSTGF
MYALIPRLSF LESLAIAACI TATDPVLASS IVGKGKFARR VPGHLRNMLL AESGCNDGMA
IPFLYLAIYL IIEKPARHAG RDWVCIIILY ECTFGCVLGA IIGVIARKMI KFSERRGLMD
RESFLVFYFV LALFCGGIGT IIGVDDLLVS FCAGAAFSWD SWFSKKTEES HVSNVIDLLL
NLSFFVYVGA IMPWPQFHMP HMDLSVWRLV VLAICILIAR RIPAVLLFKS FVPDIINWRE
ALFAGHFGPI GVGALYTCLV ARAELEVHST VPEPNDAIEN PEIPNWYCIQ VMWPVVCFLV
LSSIIVHGSS IAFFMLGKRI NTLALSFTRT RDSHFAFNLP RVRQGQSLPI KRVDALRSSA
NSIASSIRRR HPVNIQEDED ADISTVSLPE AAHLREERAE SPRGGHYDAE EFPSEDYESR
QPRRSNEEDR EEEMNPGDET YLIGEDLVVE DSQGNIISHT SSRDANGPSI DEKLAQGDPK
AKSFGRKFRS FLRRSYDTFQ RNLHEPDDER QREPTLGHIE SSIENHRPRY SRQNSESHLR
ENSVERRRRE QVLTNIGDSE SEDDNIPRPG IVPFYNENNE SSSDTRNGLL SDNVSESRSR
RPSRAPSAAV SSEGSPVEED NEAQHRPNIR FLELTRAWE
