NAH2_ZYGRO
ID NAH2_ZYGRO Reviewed; 808 AA.
AC O42701;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Na(+)/H(+) antiporter 2;
GN Name=SOD22;
OS Zygosaccharomyces rouxii (Candida mogii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX NCBI_TaxID=4956;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 42981 / IAM 12879 / JCM 22060 / S-96;
RX PubMed=9791888;
RX DOI=10.1002/(sici)1097-0061(19980930)14:13<1167::aid-yea318>3.0.co;2-5;
RA Iwaki T., Higashida Y., Tsuji H., Tamai Y., Watanabe Y.;
RT "Characterization of a second gene (ZSOD22) of Na+/H+ antiporter from salt-
RT tolerant yeast Zygosaccharomyces rouxii and functional expression of ZSOD2
RT and ZSOD22 in Saccharomyces cerevisiae.";
RL Yeast 14:1167-1174(1998).
CC -!- FUNCTION: Sodium export from cell, takes up external protons in
CC exchange for internal sodium ions. Seems to be poorly expressed.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the fungal Na(+)/H(+) exchanger family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB010106; BAA24268.1; -; Genomic_DNA.
DR AlphaFoldDB; O42701; -.
DR SMR; O42701; -.
DR TCDB; 2.A.36.4.2; the monovalent cation:proton antiporter-1 (cpa1) family.
DR PRIDE; O42701; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0030004; P:cellular monovalent inorganic cation homeostasis; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR013928; Cation/H_antiporter_C.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR004712; Na+/H+_antiporter_fungi.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR032516; Nha1.
DR PANTHER; PTHR31382:SF4; PTHR31382:SF4; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF08619; Nha1_C; 1.
DR TIGRFAMs; TIGR00844; c_cpa1; 1.
PE 3: Inferred from homology;
KW Antiport; Glycoprotein; Ion transport; Membrane; Sodium; Sodium transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..808
FT /note="Na(+)/H(+) antiporter 2"
FT /id="PRO_0000052409"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 432..452
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 478..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 779..794
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 291
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 545
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 602
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 808 AA; 90198 MW; 3C8EAF32DA1B40ED CRC64;
MAWSQLEVTK AHVAYSCVGI FSSIFSLVSL FVKEQLYIGE SMVASIFGLI VGPHCLNWFN
PLSWGNTDSI TLEISRILLC LQVFAVSVEL PRKYMLKHWV SVTMLLVPVM TSGWLVIALF
VWILVPGLNF PASLLMGACI TATDPVLAQS VVSGTFAQKV PGHLRNLLSC ESGCNDGLAI
PFVFLSLDLL LYPGRGGQIV KDWICVTILW ECIFGSILGC IIGYCGRKAI RFAEGRHIID
RESFLAFYLI LALTCAGFGS MLGVDDLLVS FFAGTAFAWD GWFAAKTHES NVSNVIDVLL
NYAYFVYLGS ILPWKDFNNP DIGLDVWRLI LLSLVVIFLR RIPAVLSLKP LIPDIKSWRE
AMFIGHFGPI GVGAVFAAIT SKSQLESHLT NEETPLKDTP GRGSKHWQVM ACIWPITCFS
IMTSVIVHGS SVAVIMLGRY LSTVTLMALP TGRTTNTKNA WLERLPALDK SGRPFSLQRL
DKEPSLSPGQ IGGRTSGMVA TPKLGMRQRW RQKLQDNKEI EPDIEMNNFC QGTFQIRKET
HASTNDSHGT TTANLGTSNG RAQGLPWRSK MNIIDRAEAV NTIYGLDKLA EDTENKDVWR
VNTSRIPGIR SPYDDVYTYQ SDSSSIGSIE RQRIKSLREQ EQQAYIAYTE DDQVIIENRQ
GEILEYVKFH KEGLGDAESG LHNHDRPKRA ISPPLEKLHQ ITNEARKNKY YAYKVGNDLV
IEDESGEVFR RYRISPHGGK RKIKKIINPV SSVLSSVGIT KPRGVSERIN HYLLHSEDEM
ADDEAESEND MDYEDSDGPA SRFKDHAD
